[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644099":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":45,"locations":50,"responsibleParty":64,"collaborators":31,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":31,"enrollmentInfo":77,"targetDuration":31,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":91,"whyStopped":31,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8,16,19,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Asthma: Water Then EVOOW","EXPERIMENTAL","After FP administration, participants will rinse and gargle with 3 consecutive aliquots of either Water (W) or EVOOW mix each on separate days, 7-10 days apart, assigned in random order.",[13,14,15],"Drug: Fluticasone Propionate","Other: Water Mouthwash","Other: EVOOW Mouthwash",{"label":17,"type":10,"description":11,"interventionNames":18},"Asthma: EVOOW Then Water",[13,14,15],{"label":20,"type":10,"description":11,"interventionNames":21},"Healthy Control: Water Then EVOOW",[13,14,15],{"label":23,"type":10,"description":11,"interventionNames":24},"Healthy Control: EVOOW Then Water",[13,14,15],[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Fluticasone Propionate","Participants will be administered 1 puff of 220 micrograms FP, via Metered Dose Inhaler, without inhaling into the lungs.",[17,9,23,20],null,{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Water Mouthwash","Participants will rinse and gargle with 3 consecutive aliquots (20ml each) of either Water (W).",[17,9,23,20],{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"EVOOW Mouthwash","Participants will rinse and gargle with 3 consecutive aliquots (20 ml each) of an equal parts EVOO and Water mixture.",[17,9,23,20],[41],{"name":42,"affiliation":43,"role":44},"Mihaela Teodorescu, MD, MS","UW School of Medicine and Public Health","PRINCIPAL_INVESTIGATOR",[46],{"name":42,"role":47,"phone":48,"phoneExt":31,"email":49},"CONTACT","608-256-1901","mt3@medicine.wisc.edu",[51],{"facility":52,"status":31,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":31},"University of Wisconsin","Madison","Wisconsin","53792","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-89.40123,43.07305,{"lat":62,"lon":61},{"type":65,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100644099","phase-4-novel-method-for-removal-of-orally-deposited-inhaled-fluticasone-propionate-100644099",false,"NCT07664527","Novel Method for Removal of Orally Deposited Inhaled Fluticasone Propionate","A Proof-of-Concept Study of a Novel Method for Removal of Residual Oropharyngeal Inhaled Corticosteroid Deposits in Asthma","EVOOW","Inclusion Criteria:\n\n* Healthy adults and adults with asthma, age 18 years and older\n* Willing to hold orally and nasally inhaled corticosteroids (ICS) for 24h and 12h, respectively, before study visits with mouthwash sample collections (Visit 2 and Visit 3)\n* No systemic or topical ocular corticosteroid use for the prior 4 weeks.\n\nExclusion Criteria:\n\n* Known hypersensitivity to fluticasone propionate\n* Allergy to olives or olive oil\n* Known allergy to oxymetazoline\n* Current smoking or vaping\n* Currently pregnant or trying to become pregnant.",true,"ALL","18 Years",{"count":78,"type":79},20,"ESTIMATED","INTERVENTIONAL",[82],"PHASE4","This study is to find out if an Extra Virgin Olive-Oil-based Water (EVOOW) mix, removes more Fluticasone Propionate (FP) from the mouth than Water alone. 2 strengths of the EVOOW mix will be tested, one with equal parts EVOO and Water (50\u002F50) and one with 3 parts EVOO and 1 part Water (75\u002F25). Removing more FP deposits may help decrease the risk for obstructive sleep apnea (OSA), candidiasis (thrush), and speech and swallow dysfunction. Participants will be on study for up to 3 weeks.",[85],"Asthma",[28,87,88,89,90],"EVOO","upper airway","oral deposits","inhaler","NOT_YET_RECRUITING","2026-06-29",{"date":94,"type":95},"2026-07-01","ACTUAL",{"date":97,"type":79},"2026-07",{"date":99,"type":79},"2027-04",{"name":5,"class":6},1]