[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622859":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":28,"locations":34,"responsibleParty":51,"collaborators":11,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":11,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":11,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Port Said University hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group OFA (Opioid-Free Anesthesia):","ACTIVE_COMPARATOR",null,[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":11,"interventionNames":16},"Group OBA (Opioid-Based Anesthesia)",[17],"Drug: Fentanyl (IV)",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Dexmedetomidine","patients will Receive dexmedetomidine with a loading dose of 1 μg\u002Fkg followed by a maintenance infusion of 0.5 μg\u002Fkg\u002Fh.",[9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Fentanyl (IV)","patients will Receive fentanyl with a loading dose of 1 μg\u002Fkg followed by a maintenance infusion of 0.5 μg\u002Fkg\u002Fh.",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Nashwa gomaa Ahmed, MD","CONTACT","00201005289328","dr_nashwa_2008@yahoo.com",[35],{"facility":36,"status":37,"city":38,"state":11,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Port said university","RECRUITING","Port Said","42111","Egypt","EG",{"type":43,"coordinates":44},"Point",[45,46],32.3019,31.26531,{"lat":46,"lon":45},[49],{"name":50,"role":31,"phone":32,"phoneExt":11,"email":33},"nashwa gomaa ahmed, MD",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Nashwa Ahmed",", Lecturer of Anaesthesia and Surgical Intensive Care, Faculty of Medicine, Port Said University, Egypt","100622859","phase-4-opioid-free-anesthesia-versus-opioid-based-anesthesia-for-adolescent-idiopathic-scoliosis-100622859",false,"NCT07389096","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis","Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis A Prospective Randomized Double-Blind Controlled Trial","Inclusion Criteria:Patients younger than 18 years of age, classified as American Society of Anesthesiologists (ASA) Physical Status I or II, and will be scheduled for surgical correction of adolescent idiopathic scoliosis.\n\n\\-\n\nExclusion Criteria:• Refusal to participate in the study or to allow use of personal data\n\n* Non-idiopathic scoliosis\n* Contraindications to commonly used perioperative medications\n* ASA Physical Status ≥ III\n* Presence of neuromuscular disorders or severe cardiac dysfunction\n* Requirement for postoperative mechanical ventilation\n* Regular use of analgesics or opioids\n* History of allergy to opioids or dexmedetomidine\n* Diagnosed mental disorders\n* Severe hepatic or renal dysfunction\n* Coagulopathy or significant pulmonary disease\n* Preoperative or postoperative neurological deficits\n* Occurrence of serious arrhythmia, hypotension, or bradycardia necessitating discontinuation of dexmedetomidine infusion","ALL","8 Years","18 Years",{"count":66,"type":67},30,"ESTIMATED","INTERVENTIONAL",[70],"PHASE4","Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids. This technique employs a combination of antinociceptive agents targeting various pathways within the central and peripheral nervous systems to achieve effective analgesia.\n\nDexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, is a centrally acting non-opioid agent increasingly utilized in clinical practice for its antinociceptive and anxiolytic properties. Only a few prospective randomized controlled trials have specifically examined the postoperative analgesic efficacy of intraoperative dexmedetomidine infusion in patients undergoing spinal surgery, with limited data focusing on this as a primary endpoint. Importantly, no clinical studies have investigated its analgesic impact in patients undergoing spinal surgery under general anesthesia.",[73],"Opioid Free Anesthesia","2026-01-30",{"date":76,"type":77},"2026-02-05","ACTUAL",{"date":74,"type":67},{"date":80,"type":67},"2027-01-31",{"name":53,"class":6},1]