[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556051":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":24,"locations":25,"responsibleParty":43,"collaborators":24,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":24,"enrollmentInfo":57,"targetDuration":24,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":70,"whyStopped":24,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Universidade do Porto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intraosseous and intra-articular PRP","ACTIVE_COMPARATOR","Two intraosseous injections of PRP and another intra-articular injection of PRP on the same day.",[13],"Combination Product: Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration",{"label":15,"type":10,"description":16,"interventionNames":17},"Intra-articular PRP","Patients submited to two intra-articular injections of PRP, separated by one week.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"COMBINATION_PRODUCT","Platelet rich-plasma - PRP - intraosseous and intra-articular admnistration","Group 1 will receive two intraosseous injections of PRP and a subsequent\u002Fsynchronous intra-articular injection of PRP on the same day.\n\nGroup 2 will only receive two intra-articular injections of PRP, separated by one week.",[15,9],null,[26,38],{"facility":27,"status":24,"city":28,"state":24,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":24},"Faculdade de Medicina da Universidade do Porto","Porto","4200 - 319","Portugal","PT",{"type":33,"coordinates":34},"Point",[35,36],-8.61097,41.1485,{"lat":36,"lon":35},{"facility":27,"status":24,"city":28,"state":24,"zip":39,"country":30,"countryCode":31,"cosmosGeoPoint":40,"geoPoint":42,"contacts":24},"4200-319",{"type":33,"coordinates":41},[35,36],{"lat":36,"lon":35},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","João Rocha Neves","MD, MSC, MPH, PHD, FEBVS","100556051","phase-4-optimal-articular-solutions-with-intraosseous-and-synovial-platelet-rich-plasma-100556051",false,"NCT06520059","Optimal Articular Solutions With Intraosseous and Synovial Platelet-Rich Plasma","Comparison of Efficacy of Intraosseous vs Intra-articular Injections of PRP for Advanced Knee OA","OASIS-PRP","Inclusion Criteria:\n\n* Adult individuals with unilateral or bilateral symptomatic knee OA diagnosis according to the American College of Rheumatology\n* with symptoms for more than 3 months\n* confirmed with radiologic diagnosis (Kellgren-Lawrence grades III or IV).\n* Patients must be able to walk with a painful knee.\n\nExclusion Criteria:\n\n* previous history of knee surgery\n* systemic autoimmune or rheumatic disease\n* platelet diseases\n* use of NSAIDs 3 days prior the injections\n* previous history (last 3 months) of systematic use of corticosteroids\n* or other intra-articular injections in the knee in the past 6 months","ALL","45 Years",{"count":58,"type":59},50,"ESTIMATED","INTERVENTIONAL",[62],"PHASE4","This is a prospective cohort clinical study. Due to logistic constraints at the sites of implementation, a randomized allocation will not be feasible (private clinic). Patients will be selected with the aim of matching for important confounders (sex and age) the grade of knee OA will be restricted to advance stages.",[65],"Knee Osteoarthritis",[67,68,69],"Injections, Intra-Articula;","Regenerative Medicine;","Cartilage Repair","NOT_YET_RECRUITING","2024-08-02",{"date":73,"type":74},"2024-08-06","ACTUAL",{"date":76,"type":59},"2025-01-01",{"date":78,"type":59},"2027-10-31",{"name":5,"class":6},2]