[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100469889":3},{"organization":4,"armGroups":7,"interventions":42,"overallOfficials":48,"centralContacts":137,"locations":148,"responsibleParty":374,"collaborators":48,"id":376,"slug":377,"hasResults":378,"nctId":379,"briefTitle":380,"officialTitle":380,"acronym":381,"eligibilityCriteria":382,"healthyVolunteers":378,"sex":383,"minAge":384,"maxAge":48,"enrollmentInfo":385,"targetDuration":48,"studyType":388,"phases":389,"briefSummary":391,"conditions":392,"keywords":48,"overallStatus":151,"whyStopped":48,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":398,"completionDateStruct":400,"leadSponsor":402,"locationsCount":403},{"fullName":5,"class":6},"Fundacion Clinic per a la Recerca Biomédica","OTHER",[8,25],{"label":9,"type":10,"description":11,"interventionNames":12},"OPAT","ACTIVE_COMPARATOR","Patients with infective endocarditis diagnostic, who have completed at least 10 days of intravenous therapy, and\u002F or seven days in the case of cardiac valvular surgery, and shown good clinical evolution and no clinical or echocardiographic signs of potential bad prognosis will be randomized. If assigned to this arm the patient will recieve parenteral antibiotics until the end of treatment.",[13,14,15,16,17,18,19,20,21,22,23,24],"Drug: Cefaclor","Drug: Ciprofloxacin Injection","Drug: Clindamycin Injection","Drug: Dicloxacillin","Drug: Fusidic Acid Only Product in Parenteral Dose Form","Drug: Levofloxacin Injection","Drug: Linezolid Injectable Product","Drug: Moxifloxacin Injectable Product","Drug: Rifampicin Only Product in Parenteral Dose Form","Drug: Sulfamethoxazole \u002F Trimethoprim Injectable Product","Drug: Tedizolid Injection","Drug: Amoxicillin",{"label":26,"type":27,"description":28,"interventionNames":29},"Oral Therapy","EXPERIMENTAL","Patients with infective endocarditis diagnostic, who have completed at least 10 days of intravenous therapy, and\u002F or seven days in the case of cardiac valvular surgery, and shown good clinical evolution and no clinical or echocardiographic signs of potential bad prognosis will be randomized. If assigned to this arm the patient will recieve oral antibiotics until the end of treatment.",[30,31,32,33,34,35,36,37,38,39,40,41],"Drug: Ciprofloxacin Tablets","Drug: Clindamycin Oral Capsule","Drug: Dicloxacillin Oral Capsule","Drug: Fusidic Acid Only Product in Oral Dose Form","Drug: Levofloxacin Oral Tablet","Drug: Linezolid Oral Tablet","Drug: Moxifloxacin tablet","Drug: Rifampicin Only Product in Oral Dose Form","Drug: Sulfamethoxazole \u002F Trimethoprim Oral Tablet [Bactrim]","Drug: Tedizolid Oral Tablet","Drug: Amoxicillin Capsules","Drug: Cefaclor Capsules",[43,49,53,57,61,65,69,73,77,81,85,88,92,95,99,102,106,110,114,117,121,125,129,133],{"type":44,"name":45,"description":46,"armGroupLabels":47,"otherNames":48},"DRUG","Cefaclor","cefaclor intravenous 2 gr\u002Fday",[9],null,{"type":44,"name":50,"description":51,"armGroupLabels":52,"otherNames":48},"Ciprofloxacin Tablets","500-750 mg\u002F12 hrs (maximum 3g x 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Canarias","San Cristóbal de La Laguna","Santa Cruz de Tenerife","38320",{"type":157,"coordinates":355},[356,357],-16.32014,28.4853,{"lat":357,"lon":356},[360],{"name":164,"role":140,"phone":165,"phoneExt":146,"email":166},{"facility":362,"status":363,"city":364,"state":365,"zip":366,"country":154,"countryCode":155,"cosmosGeoPoint":367,"geoPoint":371,"contacts":372},"Hospital Universitari i Politècnic La Fe","NOT_YET_RECRUITING","Valencia","València","46009",{"type":157,"coordinates":368},[369,370],-0.37966,39.47391,{"lat":370,"lon":369},[373],{"name":164,"role":140,"phone":165,"phoneExt":146,"email":166},{"type":222,"investigatorFullName":139,"investigatorTitle":375,"investigatorAffiliation":5,"oldNameTitle":48,"oldOrganization":48},"Project Manager Clinical Trial Unit","100469889","phase-4-oral-antimicrobial-treatment-vs-outpatient-parenteral-for-infective-endocarditis-100469889",false,"NCT05398679","Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis","OraPAT-IEGAMES","Inclusion Criteria:\n\n* Left-sided native or prosthetic infective endocarditis based on the modified Duke criteria infected with one of the following nonresistant microorganisms: Non-resistant streptococci and other gram positive cocci,e.g., Granulicatella and Abiotrophia; Enterococcus faecalis; Staphylococcus aureus;coagulase-negative staphylococci and HACEK group.\n* Male or female 18 years old or older.\n* 10 days or more of appropriate parenteral antibiotic treatment overall and at least one week of appropriate parenteral treatment after value surgery.\n* Temperature inferior to 38ºC for more than two days. 5. C-reactive protein dropped to \\\u003C25% of peak value or \\\u003C20 mg\u002Fl, and white blood cell count \\\u003C15x10\\^9\u002Fl during antibiotic treatment\n* Transthoracic \u002F transesophageal echocardiography performed within 48 hours of randomization\n\nExclusion Criteria:\n\n* Body mass index \\>40\n* Concomitant infection requiring intravenous antibiotic therapy\n* Inability to give informed consent to participation\n* Suspicion of reduced absorption of oral treatment due to abdominal disorder\n* Microorganisms with no oral combinations for treatment (two active antibiotics of different families)\n* Any immunosuppressive disease or any medical condition at the discretion of the investigator that may preclude oral or OPAT therapy\n* No family or appropriate home support\n* Reduced compliance\n* Women of childbearing potential with a positive pregnancy test, or participants (male or female) who wish to plan a pregnancy during the trial period\n* Women in lactancy period","ALL","18 Years",{"count":386,"type":387},360,"ESTIMATED","INTERVENTIONAL",[390],"PHASE4","Non-inferiority trial to determine whether partial oral treatment is non-inferior to OPAT(Outpatient parenteral therapy) in patients diagnosed with infective endocarditis",[393],"Endocarditis Infective","2026-02-23",{"date":396,"type":397},"2026-02-25","ACTUAL",{"date":399,"type":397},"2022-08-17",{"date":401,"type":387},"2027-12-30",{"name":5,"class":6},20]