[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584850":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":39,"centralContacts":43,"locations":31,"responsibleParty":53,"collaborators":31,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":31,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":31,"enrollmentInfo":65,"targetDuration":31,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":79,"whyStopped":31,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":31},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Oral-Short Arm: 1.95g TXA daily POD 1-3","ACTIVE_COMPARATOR","1.95g TXA daily for post operative days 1-3",[13],"Drug: tranexamic acid Oral-Short Arm",{"label":15,"type":10,"description":16,"interventionNames":17},"Oral-Long Arm","1.95g TXA daily for post operative days 1-7",[18],"Drug: tranexamic acid Oral-Long Arm",{"label":20,"type":21,"description":22,"interventionNames":23},"Control Group: Placebo for 3 days post-op","PLACEBO_COMPARATOR","Placebo for 3 days post-op",[24],"Drug: Control group placebo",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","tranexamic acid Oral-Short Arm","1.95g Tranexamic acid daily for post op days 1 to 3",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"tranexamic acid Oral-Long Arm","1.95g tranexamic acid daily post op days 1-7",[15],{"type":27,"name":37,"description":22,"armGroupLabels":38,"otherNames":31},"Control group placebo",[20],[40],{"name":41,"affiliation":5,"role":42},"Bailey Terhune, MD","PRINCIPAL_INVESTIGATOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":31,"email":48},"Anne DeBenedetti, MSc","CONTACT","13124322468","anne.debenedetti@rushortho.com",{"name":50,"role":46,"phone":51,"phoneExt":31,"email":52},"Marisa Toschi, BS","312-432-2455","marisa.toschi@rushortho.com",{"type":42,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Bailey Terhune","Principle Investigator","100584850","phase-4-oral-tranexamic-acid-after-total-knee-arthroplasty-100584850",false,"NCT06894719","Oral Tranexamic Acid After Total Knee Arthroplasty","Prolonged Oral Tranexamic Acid Use in Primary Total Joint Arthroplasty: A Double Blind Randomized Placebo Controlled Trial","Inclusion Criteria:\n\n* Any patient undergoing primary TKA at Rush main hospital or participating ASC\n* Willingness to undergo randomization to take medication potentially up to 7 days post op.\n* Willing to answer daily questions on pain, functionality and opioid consumption\n\nExclusion Criteria:\n\n* History of venous thromboembolism, MI, or stroke in the past year\n* Patients on any chronic anticoagulation medications besides Aspirin\n* Patients with Cancer\n* Patients with end stage renal disease that are on dialysis\n* Drug allergy to TXA\n* Taking oral birth control\n* Unable to provide consent","ALL","18 Years",{"count":66,"type":67},351,"ESTIMATED","INTERVENTIONAL",[70],"PHASE4","This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA). The study will assess pain, function, and range of motion (ROM) over a 2-year period, with key evaluations at 6 weeks and 90 days postoperatively.\n\nHypothesis:\n\nPatients receiving 1.95g oral TXA for 3 or 7 days post-op will show improved pain, function, and ROM at 6 weeks and 90 days, with similar blood loss and transfusion rates as the control group.",[73],"Total Knee Arthroplasty",[75,76,77,78],"tranexamic acid","range of motion","postoperative pain","postoperative function","NOT_YET_RECRUITING","2026-02-20",{"date":82,"type":83},"2026-02-23","ACTUAL",{"date":85,"type":67},"2026-06-01",{"date":87,"type":67},"2027-05-01",{"name":5,"class":6}]