[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611085":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":60,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":25,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":89,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Xiangya Hospital of Central South University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Acetaminophen group","EXPERIMENTAL","Intravenous acetaminophen is the analgesic of choice for patients in the acetaminophen group",[13],"Drug: Acetaminophen group",{"label":15,"type":16,"description":17,"interventionNames":18},"Sufentanil group","ACTIVE_COMPARATOR","Intravenous sufentanil is the analgesic of choice for patients in the sufentanil group",[19],"Drug: Sufentanil group",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","The pain in this group is controlled using acetaminophen (Paracetamol and Maninitol Injection, Yichang Renfu Medicine Co., Ltd., China), 500 mg, intravenous bolus, every 6 hours for the first 48 hours postoperatively. The severity of pain is assessed using NRS every 15 minutes during the first hour following ICU admission and then once every 12 hours needed.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"he pain in this group is controlled using sufentanil (Yichang Renfu Medicine Co., Ltd., China) intravenous infusion with a rate of 0.05 μg\u002Fkg\u002Fh. The severity of pain is assessed using NRS every 15 minutes during the first hour following ICU admission and then once every 12 hours needed.",[15],[30],{"name":31,"affiliation":32,"role":33},"Yixiong Li","Central South University","STUDY_CHAIR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Lina Zhang, Dr.","CONTACT","86+15874875763","zln7095@163.com",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Milin Peng, Dr.","86+15211040348","pengmilin@csu.edu.cn",[45],{"facility":46,"status":25,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Xiangya hospital","Changsha","Hunan","410000","China","CN",{"type":53,"coordinates":54},"Point",[55,56],112.97087,28.19874,{"lat":56,"lon":55},[59],{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","icuzhanglina","Professor","100611085","phase-4-paracetamol-and-mannitol-injection-and-postoperative-delirium-100611085",false,"NCT07235995","Paracetamol and Mannitol Injection and Postoperative Delirium","Impact of Paracetamol and Mannitol Injection Analgesia on Postoperative Delirium in Elderly Patients After Non-cardical Surgery: A Randomized Controlled Trial","PAPOD-ES","Inclusion Criteria:\n\n* Age ≥ 60 years;\n* Admitted to ICU after a noncardiac surgical procedure\n* Moderate to severe acute pain, with a postoperative pain score ≥ 5 based on the 11-point Numerical Pain Rating Scale (NPRS)\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Preoperative medical history: schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis\n* History of psychiatric disease or significant neurocognitive disorder such as dementia or retardation, making POD assessment impossible\n* Language or communication barrier making POD assessment impossible\n* Intracranial surgery\n* Severe hepatic dysfunction prohibiting the use of acetaminophen per the standard of care\n* Participation in a competing study within 30d\n* Patients experienced intraoperative or postoperative complications, and the investigator determined the subject was unsuitable to continue participation in the study\n* Intolerant to paracetamol or opioid drugs","ALL","60 Years",{"count":75,"type":76},1092,"ESTIMATED","INTERVENTIONAL",[79],"PHASE4","The aim of this multi-center RCT is to investigate the effect of intravenous acetaminophen (paracetamol and mannitol injection) on postoperative delirium, comparing with intravenous sufentanil, in elderly noncardiac surgical patients admitted to ICU.",[82,83,84],"Postoperative Delirium","Elderly","Non Cardiac Surgery",[86,87,83,88],"Postoperative delirium","Intravenous acetaminophen","Noncardiac surgical patients","NOT_YET_RECRUITING","2025-11-17",{"date":92,"type":93},"2025-11-19","ACTUAL",{"date":95,"type":76},"2025-12-01",{"date":97,"type":76},"2027-04-30",{"name":5,"class":6},1]