[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600834":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":62,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":25,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":25,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Thomas Jefferson University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Staggered","ACTIVE_COMPARATOR","Medications administered 3H apart (Staggered)",[13,14],"Drug: Acetaminophen","Drug: NSAID (Ketorolac\u002FIbuprofen)",{"label":16,"type":10,"description":17,"interventionNames":18},"Simultaneous","Medications administered at the same time. (Simultaneous)",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Acetaminophen","Acetaminophen 1000 mg q6H",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"NSAID (Ketorolac\u002FIbuprofen)","NSAID (ketorolac 30 mg q6H for first 24 hours post-op followed by ibuprofen 600 mg q6H)",[16,9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Whitney Bender, MD","CONTACT","434-294-8416","whitney.bender@jefferson.edu",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},"Brandy Firman","215-586-1656","brandy.firman@jefferson.edu",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Thomas Jefferson University Hospital","RECRUITING","Philadelphia","Pennsylvania","19107","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-75.16362,39.95238,{"lat":53,"lon":52},[56,59,60],{"name":57,"role":33,"phone":58,"phoneExt":25,"email":35},"Whitney Bender","494-294-8416",{"name":37,"role":33,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":61,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"type":61,"investigatorFullName":57,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Assistant Professor, Department of Obstetrics and Gynecology","100600834","phase-4-post-cesarean-analgesia-comparing-effectiveness-of-staggered-v-simultaneous-therapies-100600834",false,"NCT07102641","Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies","PACESS: Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies","PACESS","Inclusion Criteria:\n\n* \\>\u002F= 34 weeks gestation\n* Singleton pregnancy\n* Delivery via cesarean section under regional anesthesia\n\nExclusion Criteria:\n\n* Contraindication to acetaminophen or NSAIDs\n* Current or history of opioid use or misuse\n* Intrauterine fetal demise\n* Major congenital anomaly\n* Conversion to general anesthesia intra-op or planned general anesthesia\n* Mid-line vertical skin incision\n* Receipt of intraoperative local analgesia such as Transversus Abdominis Plan (TAP) block or wound infiltration","FEMALE","16 Years",{"count":75,"type":76},825,"ESTIMATED","INTERVENTIONAL",[79],"PHASE4","Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.",[82,83,84,85,86,87],"Cesarean Delivery","Postpartum Comfort","Postpartum Pain","Post-operative Pain","NSAIDs","Acetaminophen (D000082)","2025-09-02",{"date":90,"type":91},"2025-09-03","ACTUAL",{"date":93,"type":91},"2025-08-26",{"date":95,"type":76},"2027-12",{"name":5,"class":6},1]