[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517861":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":38,"responsibleParty":56,"collaborators":12,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":12,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":12,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":82,"whyStopped":12,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Children's Hospital Los Angeles","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"No Steroid (NS)","NO_INTERVENTION","No Dexamethasone (NS)",null,{"label":14,"type":15,"description":16,"interventionNames":17},"With Steroid (WS)","EXPERIMENTAL","With Dexamethasone (WS)",[18],"Drug: Dexamethasone",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DRUG","Dexamethasone","Three (3) post operative intravenous dexamethasone injections at 8-hour intervals post-operatively. Dosing will be determined as 0.15 mg\u002Fkg per dose (WS)",[14],[26],{"name":27,"affiliation":5,"role":28},"Lindsay Andras, MD","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":12,"email":34},"Lindsay M Andras, MD","CONTACT","323-361-2142","landras@chla.usc.edu",{"name":36,"role":32,"phone":12,"phoneExt":12,"email":37},"Tiffany Phan, BA","tphan@chla.usc.edu",[39],{"facility":5,"status":12,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Los Angeles","California","90027","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-118.24368,34.05223,{"lat":49,"lon":48},[52,55],{"name":53,"role":32,"phone":54,"phoneExt":12,"email":37},"Tiffany Phan","3108488377",{"name":27,"role":28,"phone":12,"phoneExt":12,"email":12},{"type":28,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Lindsay Andras","Associate Division Chief and Director of the Spine Program","100517861","phase-4-postoperative-steroid-use-in-adolescent-idiopathic-scoliosis-and-neuromuscular-scoliosis-patients-100517861",false,"NCT06023043","Postoperative Steroid Use in Adolescent Idiopathic Scoliosis and Neuromuscular Scoliosis Patients","A Randomized Trial of Postoperative Steroid Use Following Posterior Spinal Fusion in 100-subject Adolescent Idiopathic Scoliosis (AIS) and Neuromuscular Scoliosis (NMS)","Inclusion Criteria:\n\nParticipants must meet all of the inclusion criteria to participate in this study:\n\n• Patients aged 9-18 years who are scheduled to undergo posterior spinal fusion to treat AIS or NMS\n\nExclusion Criteria:\n\nPatients will be excluded if any of the following criteria are met at baseline:\n\n* Prior instrumentation or spine surgery\n* Conditions associated with increased wound healing issues such as spina bifida\n* Non AIS or NMS patients\n* Not undergoing PSF\n* Outside the ages of 9-18\n* Allergies to the steroids and\u002For their ingredients\n* Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements\n* Inability or unwillingness of individual or legal guardian\u002Frepresentative to give written informed consent.","ALL","9 Years","18 Years",{"count":70,"type":71},100,"ESTIMATED","INTERVENTIONAL",[74],"PHASE4","The goal of this randomized clinical trial is to compare the immediate use of steroids after surgery for accelerated discharge in adolescent idiopathic scoliosis and neuromuscular scoliosis after a posterior spinal fusion.\n\nThe main question it aims to answer are:\n\n* What are the effects of using steroids immediately after surgery in decreasing opioid use and helping early mobilization(movement)?\n* Does post-operative steroid use affect the incidence of wound complications and are there any long-term impacts on scar formation?\n\nParticipants will:\n\n* Fill out a Patient-Reported Outcomes Measurement Information System (PROMIS) survey specifically for pain interference and physical activity observing health related quality of life at enrollment, 3 months, 1 year, and 2 years\n* Have clinical photos of their incision at 3 months, 1 year, and 2 years\n\n  * Their photos will be assessed using the stony book scar evaluation scale\n* For treatment of their scoliosis, patients will undergo a posterior spinal fusion (PSF) per standard of care, however whether the participant receives or does not receive steroids is what the investigators are trying to understand.\n* Researchers will compare no immediate postoperative steroid (NS) to the group with immediate postoperative steroid (WS) group to see if there are changes in opioid use, wound complications, scar formation, and facilitation in early mobilization.",[77,78],"Neuromuscular Scoliosis","Adolescent Idiopathic Scoliosis",[80,22,81],"Steroid","Scoliosis","NOT_YET_RECRUITING","2025-03-03",{"date":85,"type":86},"2025-03-05","ACTUAL",{"date":88,"type":71},"2025-11-01",{"date":90,"type":71},"2028-12-31",{"name":5,"class":6},1]