[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558699":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":39,"locations":45,"responsibleParty":156,"collaborators":159,"id":163,"slug":164,"hasResults":165,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":12,"eligibilityCriteria":169,"healthyVolunteers":165,"sex":170,"minAge":171,"maxAge":172,"enrollmentInfo":173,"targetDuration":12,"studyType":176,"phases":177,"briefSummary":179,"conditions":180,"keywords":12,"overallStatus":129,"whyStopped":12,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":194},{"fullName":5,"class":6},"Indiana University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-LISA Group","NO_INTERVENTION","Preterm infants with respiratory distress syndrome who are on continuous positive airway pressure support and being treated with caffeine citrate.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"LISA Group","EXPERIMENTAL","Preterm infants with respiratory distress syndrome, who are on continuous positive airway pressure support are treated with caffeine citrate and surfactant through the less invasive surfactant administration technique.",[18],"Drug: Surfactant",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Surfactant","Surfactant is instilled into the lungs through a thin catheter passed into the trachea during laryngoscopy while on continuous positive airway pressure (CPAP)",[14],[26],"Less Invasive Surfactant Administration Technique",[28,31,34,37],{"name":29,"affiliation":5,"role":30},"Osayame A Ekhaguere, MBBS, MPH","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":33,"role":30},"Helen Nabwera, BMedSci","Aga Khan University",{"name":35,"affiliation":36,"role":30},"Olufunke Bolaji, MBBS","Afe Babalola University",{"name":38,"affiliation":5,"role":30},"Edgardo Szyld, MD, MS",[40],{"name":41,"role":42,"phone":43,"phoneExt":12,"email":44},"Osayame A Ekhaguere","CONTACT","+13179443691","osaekhag@iu.edu",[46,62,76,88,101,115,127,143],{"facility":47,"status":48,"city":49,"state":12,"zip":12,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Centre Hospitalier Universitaire Communautaire","NOT_YET_RECRUITING","Bangui","Central African Republic","CF",{"type":53,"coordinates":54},"Point",[55,56],18.55496,4.36122,{"lat":56,"lon":55},[59],{"name":60,"role":42,"phone":12,"phoneExt":12,"email":61},"Cynthia N Ningatoloum, MD","cynthinaz@yahoo.fr",{"facility":63,"status":48,"city":64,"state":12,"zip":12,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Korle-Bu Teaching Hospital","Accra","Ghana","GH",{"type":53,"coordinates":68},[69,70],-0.1969,5.55602,{"lat":70,"lon":69},[73],{"name":74,"role":42,"phone":12,"phoneExt":12,"email":75},"Sally O Manu, MD","sal.omanu83@gmail.com",{"facility":77,"status":48,"city":78,"state":12,"zip":12,"country":65,"countryCode":66,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Komfo Anokye Teaching Hospital","Kumasi",{"type":53,"coordinates":80},[81,82],-1.62443,6.68848,{"lat":82,"lon":81},[85],{"name":86,"role":42,"phone":12,"phoneExt":12,"email":87},"Naana A. Wireko Brobby, MD","mayiwah@yahoo.com",{"facility":89,"status":48,"city":90,"state":12,"zip":12,"country":65,"countryCode":66,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"Tamale Teaching Hospital","Tamale",{"type":53,"coordinates":92},[93,94],-0.8393,9.40079,{"lat":94,"lon":93},[97],{"name":98,"role":42,"phone":99,"phoneExt":12,"email":100},"Alhassan Abdul-Mumin, MD MS","+233546439573","amumuni14@yahoo.co.uk",{"facility":102,"status":48,"city":103,"state":12,"zip":12,"country":104,"countryCode":105,"cosmosGeoPoint":106,"geoPoint":110,"contacts":111},"Coast General Teaching & Referral Hospital","Mombasa","Kenya","KE",{"type":53,"coordinates":107},[108,109],39.66359,-4.05466,{"lat":109,"lon":108},[112],{"name":113,"role":42,"phone":12,"phoneExt":12,"email":114},"Nayirat Mohamed, MD","nayiratdor@gmail.com",{"facility":116,"status":48,"city":117,"state":12,"zip":12,"country":104,"countryCode":105,"cosmosGeoPoint":118,"geoPoint":122,"contacts":123},"Mama Lucy Kibaki Hospital","Nairobi",{"type":53,"coordinates":119},[120,121],36.81667,-1.28333,{"lat":121,"lon":120},[124],{"name":125,"role":42,"phone":12,"phoneExt":12,"email":126},"Justus M Simba, MD","jsimba@jkuat.ac.ke",{"facility":128,"status":129,"city":130,"state":131,"zip":12,"country":132,"countryCode":133,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Federal Teaching Hospital Ido-Ekiti","RECRUITING","Ido-Ekiti","Ekiti State","Nigeria","NG",{"type":53,"coordinates":135},[136,137],5.18314,7.84598,{"lat":137,"lon":136},[140],{"name":141,"role":42,"phone":12,"phoneExt":12,"email":142},"Samuel Ajigbotosho, MBBS","samajigbotosho@gmail.com",{"facility":144,"status":129,"city":145,"state":146,"zip":12,"country":132,"countryCode":133,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"University of Ilorin Teaching Hospital","Ilorin","Kwara State",{"type":53,"coordinates":148},[149,150],4.54214,8.49664,{"lat":150,"lon":149},[153],{"name":154,"role":42,"phone":12,"phoneExt":12,"email":155},"Oluwabunmi Mokuolu, MBBS","oluwabunmiabogunrin@yahoo.com",{"type":30,"investigatorFullName":157,"investigatorTitle":158,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Osayame Ekhaguere","Assistant Professor of Pediatrics",[160],{"name":161,"class":162},"Coefficient Giving (Formerly Open Philanthropy)","UNKNOWN","100558699","phase-4-pragmatic-evaluation-of-respiratory-distress-syndrome-treatment-in-africa-100558699",false,"NCT06554522","Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa","Pragmatic Evaluation of Therapies to Enhance Respiratory Management in Preterm Infants in Africa","Inclusion Criteria:\n\n* Birth weight between 750 and 2000 grams or gestational age between 24- and 35 weeks.\n* Silverman Anderson Score ≥5 before or after CPAP treatment.\n* Admitted to a study site within 24 hours of life.\n\nExclusion Criteria:\n\n* Major congenital or genetic anomalies.\n* Active pulmonary hemorrhage.\n* Major craniofacial anomalies that preclude the successful use of CPAP","ALL","1 Hour","24 Hours",{"count":174,"type":175},1512,"ESTIMATED","INTERVENTIONAL",[178],"PHASE4","The goal of this pragmatic clinical trial is to learn if the drug surfactant given by a less invasive technique works to treat respiratory distress in preterm infants in low- and middle-income African countries where invasive ventilators are unavailable. It will also learn about the safety of the less invasive surfactant administration (LISA) technique. The main questions it aims to answer are:\n\nDoes surfactant given by a less invasive surfactant administration technique improve survival in preterm infants in low- and middle-income countries? What medical problems do participants have when receiving surfactant given by the less invasive surfactant administration technique?\n\nResearchers will implement the less invasive surfactant administration technique and see if it works to treat respiratory distress in preterm infants compared to preterm who did not receive surfactant.\n\nParticipants with respiratory distress who are being treated with continuous positive airway pressure and caffeine citrate will:\n\nReceive surfactant replacement therapy by the less invasive surfactant administration technique.\n\nBe monitored for complications Be followed throughout their hospitalization to determine their survival rate.",[181,182,183,184],"Respiratory Distress Syndrome in Premature Infant","RDS of Prematurity","Surfactant Deficiency Syndrome Neonatal","Premature Birth","2026-03-23",{"date":187,"type":188},"2026-03-27","ACTUAL",{"date":190,"type":188},"2025-01-01",{"date":192,"type":175},"2027-12-30",{"name":5,"class":6},8]