[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100600727":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":61,"collaborators":29,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":29,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":29,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":47,"whyStopped":29,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Prisma Health-Upstate","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Drug","ACTIVE_COMPARATOR","Acetazolamide 500mg ER",[13],"Drug: Acetazolamide 500 MG Extended Release Oral Capsule",{"label":15,"type":10,"description":16,"interventionNames":17},"Placebo","Inactive Placebo Capsule",[18],"Drug: Placebo",[20,26],{"type":21,"name":22,"description":9,"armGroupLabels":23,"otherNames":24},"DRUG","Acetazolamide 500 MG Extended Release Oral Capsule",[9],[25],"Diamox",{"type":21,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"Inactive Drug",[15],null,[31],{"name":32,"affiliation":33,"role":34},"Paul Miller, JDMD","Prisma Health","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":29,"email":40},"Patti Parker, BSN","CONTACT","864-455-1510","patti.parker@prismahealth.org",{"name":42,"role":38,"phone":43,"phoneExt":29,"email":44},"Paul Miller, MD","864-455-1600","paul.miller@prismahealth.org",[46],{"facility":33,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Greenville","South Carolina","29605","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-82.39401,34.85262,{"lat":57,"lon":56},[60],{"name":37,"role":38,"phone":39,"phoneExt":29,"email":40},{"type":62,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100600727","phase-4-preoperative-acetazolamide-100600727",false,"NCT07101250","Preoperative Acetazolamide","Preoperative Acetazolamide for Improved Pain Control Following Laparoscopic Hysterectomy","Inclusion Criteria:\n\n* Women\n* Ages 21-65\n* undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy\n* undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy\n\nExclusion Criteria:\n\n* Allergy to acetazolamide or sulfonamides\n* Known electrolyte disturbances\n* Pregnancy\n* Kidney failure or creatinine \\>1.5\n* Diuretic or lithium use\n* Chronic obstructive pulmonary disease (COPD) or other lung disease\n* Central nervous system disorders\n* Liver disease\n* Glaucoma\n* Preoperative or chronic opioid use\n* Diagnosis of fibromyalgia\n* Preoperative shoulder pain\n* Conversion to laparotomy\n* Intraoperative bladder or bowel injury\n* Inability to understand or utilize visual analog scale\n* Undergoing concurrent reconstructive procedures","FEMALE","21 Years","65 Years",{"count":74,"type":75},100,"ESTIMATED","INTERVENTIONAL",[78],"PHASE4","The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.",[81,82,83],"Post Operative Pain","Laparoscopic Hysterectomy","Referred Pain",[85,86,87],"shoulder pain","laparoscopic","analgesia","2026-02-18",{"date":90,"type":91},"2026-02-20","ACTUAL",{"date":93,"type":91},"2025-10-30",{"date":95,"type":75},"2026-11-01",{"name":5,"class":6},1]