[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053257":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":42,"collaborators":26,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":26,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":72,"whyStopped":26,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":26},{"fullName":5,"class":6},"Watim Medical & Dental College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexamethasone Group","EXPERIMENTAL","Participants receive dexamethasone as an adjunct to local anesthesia before endodontic treatment for symptomatic irreversible pulpitis",[13],"Drug: dexamethasone",{"label":15,"type":16,"description":17,"interventionNames":18},"Saline","PLACEBO_COMPARATOR","participants receive normal saline as a placeb adjunct to local anesthesia before endodontic treatment for symptomatic irreversible pulpitis",[19],"Drug: Saline (0.9% NaCl)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","dexamethasone","participants receive 4mg dexamethasone administered via intraligamental infiltration followed by inferior alveolar nerve block before endodontic treatment of mandibular molars with symptomatic irreversible pulpitis",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Saline (0.9% NaCl)","participants receive an equivalent volume of normal saline administered via intraligamental infiltration before root canal treatment for symptomatic irreversible pulpitis",[15],[32],{"name":33,"affiliation":34,"role":35},"Dr.Ayesha S Janjua, BDS","Watim Medical and Dental College","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Ayesha S Janjua, BDS","CONTACT","+92 321 5252096","ashsarwar@gmail.com",{"type":35,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ayesha Sarwar","Postgraduate Resident, Department of Operative Dentistry and Endodontics","100053257","phase-4-preoperative-dexamethasone-injection-to-improve-local-anesthesia-success-in-endodontic-treatment-100053257",false,"NCT07699315","Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic Treatment","Preoperative Intraligamentary Injection of Dexamethasone Can Improve the Anesthetic Success Rate of 2% Lidocaine During the Endodontic Management of Mandibular Molars With Symptomatic Irreversible Pulpitis","DILAS","Inclusion Criteria:\n\n1. Patients with pain VAS \\>\u002F= 6\n2. Carious exposed mandibular molar with symptomatic irreversible pulpitis\n3. Patients between ages 18-60 years\n4. American Society of Anesthesiologists class I or II medical histories -\n\nExclusion Criteria:\n\n1\\. Patients with contraindications to local anesthesia solution or dexamethasone 2.Pregnant or breast-feeding females 4.Tooth having fused\u002Fextra roots, full coverage crowns, or poor periodontal status 5. Patients taking drugs which could affect the pain perception\n\n\\-","ALL","18 Years","60 Years",{"count":57,"type":58},60,"ESTIMATED","INTERVENTIONAL",[61],"PHASE4","This study aims to determine whether giving a single dose of 4mg dexamethasone before root canal treatment can reduce the amount of pain patients experience during the procedure . Patients diagnosed with symptomatic Irreversible Pulpitis requiring endodontic treatment will be enrolled. Participants will receive either dexamethasone or placebo before treatment , and pain during the procedure will be measured using a Visual Analogue Scale (VAS) .\n\nThe findings may help improve pain management strategies during root canal treatment .",[64],"Symptomatic Irreversible Pulpitis",[64,66,67,68,69,70,71],"Dexamethasone","Root canal Treatment","Intraoperative pain","Endodontics","local anesthesia","Inferior Alveolar Nerve Block","NOT_YET_RECRUITING","2026-07-09",{"date":75,"type":76},"2026-07-13","ACTUAL",{"date":78,"type":58},"2026-07",{"date":80,"type":58},"2026-12",{"name":5,"class":6}]