[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612772":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":32,"locations":26,"responsibleParty":38,"collaborators":26,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":26,"eligibilityCriteria":47,"healthyVolunteers":44,"sex":48,"minAge":49,"maxAge":26,"enrollmentInfo":50,"targetDuration":26,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":65,"whyStopped":26,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":26},{"fullName":5,"class":6},"National Cheng-Kung University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Clipping group","ACTIVE_COMPARATOR","After identifying a resectable colon polyp (size ≥ 1 cm), the operator performed a hot polypectomy. Following hot polypectomy, the wound was observed for 30 seconds to detect potential immediate bleeding. Standard endoscopic interventions such as diluted epinephrine injection, heat coagulation, or clipping were promptly administered if immediate bleeding occurred. Subsequently, the patients were randomly assigned to either the Sucralfate or Clipping groups. After allocation, prophylactic clips will be placed on the polypectomy wounds of patients in the Clipping group.",[13],"Device: Clip",{"label":15,"type":16,"description":17,"interventionNames":18},"Sucralfate group","EXPERIMENTAL","After identifying a resectable colon polyp (size ≥ 1 cm), the operator performed a hot polypectomy. Following hot polypectomy, the wound was observed for 30 seconds to detect potential immediate bleeding. Standard endoscopic interventions such as diluted epinephrine injection, heat coagulation, or clipping were promptly administered if immediate bleeding occurred. Subsequently, the patients were randomly assigned to either the Sucralfate or Clipping groups. After allocation, 3 g of sucralfate powder will be sprayed on the polypectomy wounds of patients in the Sucralfate group. The powder spray aimed for the full coverage of the polypectomy wound. Six sucralfate tablets (500 mg per Weizip tablet; Yung Shin Pharmaceutical Industries, Taichung, Taiwan) were ground to collect 3 g of sucralfate powder. This powder was then delivered through a functional powder delivery system (7F polyethylene catheter in connection by an oxygen cannula to the air source; propelling power: 1 L\u002Fmin airflow)",[19],"Drug: Sucralfate",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Sucralfate","3 g of sucralfate powder will be sprayed on the polypectomy wounds of patients in the Sucralfate group.",[15],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DEVICE","Clip","Prophylactic clips will be placed on the polypectomy wounds of patients in the Clipping group",[9],[33],{"name":34,"role":35,"phone":36,"phoneExt":26,"email":37},"Hsueh-Chien Chiang, MD","CONTACT","+88662353535","scion456scion@gmail.com",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Hsueh-Chien Chiang","Attending Physician","100612772","phase-4-prevention-of-delayed-post-polypectomy-bleeding-by-endoscopic-sucralfate-spray-in-high-risk-patients-a-randomized-controlled-trial-100612772",false,"NCT07257926","Prevention of Delayed Post-polypectomy Bleeding by Endoscopic Sucralfate Spray in High-risk Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* patients who take antiplatelets or anticoagulants with large polyps (size ≥ 1 cm)\n\nExclusion Criteria:\n\n* lacked complete data (serum creatinine, platelet count, and prothrombin time) pertaining to the previous 6 months\n* those who did not discontinue or inadequately discontinued antiplatelet agents or anticoagulants\n* those who had a known allergy to sucralfate","ALL","18 Years",{"count":51,"type":52},160,"ESTIMATED","INTERVENTIONAL",[55],"PHASE4","Background： Colonoscopy can detect colon polyps and perform excision to the polyps to prevent colon cancer. However, delayed polypectomy bleeding is one of the complications to be noticed, which has an occurrence rate of about 1-2%, especially large polyps over 1cm with hot snare polypectomy. Colonoscopic clipping was applied for the treatment of bleeding. However, prophylactic clipping after polypectomy was not proved to reduce the rate of delayed polypectomy bleeding. Sucralfate is used for peptic ulcer treatment, which can become a protective layer on the wound to prevent environmental injury. Our preliminary data revealed the endoscopic sucralfate spray could reduce the delayed bleeding rate among general populations. Whether sucralfate can prevent polypectomy wounds from delayed bleeding in high-risk polyps is unknown.\n\nAim： This study aimed to compare the efficacy in reducing delayed bleeding rate between sucralfate administration and prophylactic clipping on high-risk polypectomy wounds.\n\nMethod： This is a randomized clinical trial. The study will recruit 160 patients. After randomization, 80 patients will be classified into the Sucralfate group and 80 into the Clipping group. The participants will receive an endoscopic survey as routine, and we will enroll all patients who take antiplatelets or anticoagulants with polyp size ≥ 1 cm after hot snare polyp excision. Exclusion criteria include patients with an allergy to sucralfate. If immediate polypectomy bleeding occurs, we will apply standard endoscopic therapy by either local injection of diluted epinephrine, heater probe coagulation, and\u002For hemoclipping. After then, we will spray 3g of sucralfate powder through colonoscopy precisely on the polypectomy wound in the Sucralfate group, and prophylactic clipping will be placed on the polypectomy wound in the Clipping group. All enrolled patients will be monitored for delayed bleeding for 28 days after the colonoscopy.\n\nExpected results and clinical importance:\n\nThis study is expected to find that the use of sucralfate powder can more effectively reduce the bleeding risk in high-risk wounds compared to prophylactic clips. In addition to promoting the implementation of national health policies and reducing public exposure to the risk of complications, it can also help avoid medical expenses resulting from complications.",[58],"Bleeding After GI Endoscopy",[60,61,62,63,64],"polypectomy","sucralfate","antiplatelet","anticoagulant","postpolypectomy bleeding","NOT_YET_RECRUITING","2025-12-01",{"date":68,"type":69},"2025-12-02","ACTUAL",{"date":71,"type":52},"2025-12-15",{"date":73,"type":52},"2027-12-31",{"name":5,"class":6}]