[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607908":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":39,"locations":49,"responsibleParty":79,"collaborators":30,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":30,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":104,"overallStatus":106,"whyStopped":30,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University of Oxford","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"The standard adult vaccine dose","ACTIVE_COMPARATOR","Adults and adolescents receiving the standard adult vaccine dose",[13],"Biological: 10μg R21\u002F50μg Matrix-M",{"label":15,"type":10,"description":16,"interventionNames":17},"A half of the standard adult vaccine dose with adaptor Preservative Free","Adults and adolescents receiving a half of the standard adult vaccine dose with adaptor Preservative Free (n=125)",[18],"Biological: 5μg R21\u002F50μg Matrix-M with adaptor preservative free",{"label":20,"type":10,"description":21,"interventionNames":22},"A half of the standard adult vaccine dose with 2PE Preservative","Adults and adolescents receiving a half of the standard adult vaccine dose with 2PE Preservative (n=125)",[23],"Biological: 5μg R21\u002F50μg Matrix-M with 2PE preservative",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"BIOLOGICAL","10μg R21\u002F50μg Matrix-M","Adults and adolescents receiving the standard adult vaccine dose: 10μg R21\u002F50μg Matrix-M (n=125)",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"5μg R21\u002F50μg Matrix-M with adaptor preservative free","Adults and adolescents receiving a half of the standard adult vaccine dose: 5μg R21\u002F50μg Matrix-M using two presentations: 10 dose vials with adaptor Preservative Free (n=125)",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"5μg R21\u002F50μg Matrix-M with 2PE preservative","Adults and adolescents receiving a half of the standard adult vaccine dose: 5μg R21\u002F50μg Matrix-M using two presentations: 10 dose vials with 2PE Preservative (n=125)",[20],[40,45],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Lorenz von Seidlein","CONTACT","+66926486322","Lorenz@tropmedres.ac",{"name":46,"role":42,"phone":47,"phoneExt":30,"email":48},"Rupam Tripura","+8801572288558","Rupam@tropmedres.ac",[50,68],{"facility":51,"status":30,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Lama Upazila Health Complex","Lāma","Lama","4641","Bangladesh","BD",{"type":58,"coordinates":59},"Point",[60,61],92.21907,21.77439,{"lat":61,"lon":60},[64],{"name":65,"role":42,"phone":66,"phoneExt":30,"email":67},"Mohammad Abul Faiz","+008801613008857","drmafaiz@gmail.com",{"facility":69,"status":30,"city":70,"state":30,"zip":71,"country":55,"countryCode":56,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Alikadam Upazila Health Complex","Bāndarban","4650",{"type":58,"coordinates":73},[74,75],92.21946,22.19534,{"lat":75,"lon":74},[78],{"name":65,"role":42,"phone":66,"phoneExt":30,"email":67},{"type":80,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100607908","phase-4-r21mm-dosing-presentations-and-preservatives-100607908",false,"NCT07194668","R21\u002FMM Dosing, Presentations, and Preservatives","Immunogenicity of a Fractional Adult Dose of the Malaria Vaccine R21\u002FMatrix-M - A Noninferiority Trial","VAC100","Inclusion Criteria:\n\n* Residence in a study village for the study period, i.e. 12 months.\n* Age 14 years to 60 years.\n* Written informed consent\u002Fassent provided by participants (or a parent\u002Fguardian in case the participant is under 18 years old).\n\nExclusion Criteria:\n\n* Pregnancy, plan to get pregnant within one month of vaccination, or breastfeeding.\n* Acute illness requiring intervention.\n* A history of an adverse reaction to study vaccine.\n* Prior receipt of any other malaria vaccine.\n* Enrolment in another intervention trial in the last month.\n* Planned enrolment in another intervention trial in the coming 12 months.\n* Regular use of Immunomodulating drugs e.g, Steroid, Methotrexate, Immunotherapy etc. in the past month and\u002For planned for the coming 12 months.",true,"ALL","14 Years","60 Years",{"count":94,"type":95},375,"ESTIMATED","INTERVENTIONAL",[98],"PHASE4","This is a single blind randomised controlled trial (Phase 3 trial). This study aims to assess whether a half-dose of the R21\u002FMatrix-M malaria vaccine is as effective as the full dose in children and adults. The results will help optimize vaccine usage and improve malaria prevention strategies.\n\nAll participants will receive the same number of injections and will be randomly assigned to receive one of the followings:\n\n* Group 1: Adults and adolescents receiving the standard adult vaccine dose: 10μg R21\u002F50μg Matrix-M (n=125).\n* Group 2: Adults and adolescents receiving a half of the standard adult vaccine dose: 5μg R21\u002F50μg Matrix-M: 10 dose vials with adaptor Preservative Free (n=125)\n* Group 3: Adults and adolescents receiving a half of the standard adult vaccine dose: 5μg R21\u002F50μg Matrix-M: 10 dose vials with 2PE Preservative (n=125)\n\nClinical procedure for participants:\n\n* Standardized symptom questionnaire\n* Physical examination:\n\nWeight, height, pulse, blood pressure, respiratory rate, tympanic temperature. Spleen and liver size will be recorded if palpable. Pregnancy test (for female of child bearing potential)\n\n* Venous blood collection (Pre-vaccination) 3mL\n* Vaccination",[101,102,103],"Plasmodium Falciparum Malaria","Malaria","Vaccine Reaction",[101,105],"Malaria Vaccine","NOT_YET_RECRUITING","2026-03-12",{"date":109,"type":110},"2026-03-16","ACTUAL",{"date":112,"type":95},"2026-04-01",{"date":114,"type":95},"2026-12-31",{"name":5,"class":6},2]