[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609655":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":67,"collaborators":32,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":32,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":32,"enrollmentInfo":79,"targetDuration":32,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":32,"overallStatus":50,"whyStopped":32,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low-dose radiotherapy (LDRT)","EXPERIMENTAL","Subjects will receive a total of six (6) low-dose radiotherapy (LDRT) treatments for hand osteoarthritis.",[13],"Radiation: Low-dose radiotherapy (LDRT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Corticosteroid injection (CSI)","ACTIVE_COMPARATOR","Subjects will receive standard of care corticosteroid injection (CSI) therapy for hand osteoarthritis.",[19],"Drug: Corticosteroid injection (CSI)",[21,28],{"type":22,"name":15,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","A maximum of 3 joints will be treated with standard a standard combination of methylprednisolone and lidocaine:\n\n* 1st Carpometacarpal (CMC) joint - 20 mg methylprednisolone\u002F0.5 mL 1% lidocaine\\*\n* Radiocarpal (RC) joint - 40 mg methylprednisolone\u002F1 mL 1% lidocaine\\*\n* Scaphotrapeziotrapezoidal (STT) joint - 20 mg methylprednisolone\u002F0.5 mL 1% lidocaine\\*\n* Metacarpophalangeal (MCP) joint - 20 mg methylprednisolone\u002F0.5 mL 1% lidocaine\n* Interphalangeal (IP) joint - 10 mg methylprednisolone\u002F0.25 mL 1% lidocaine",[15],[26,27],"Methylprednisolone","Lidocaine",{"type":29,"name":9,"description":30,"armGroupLabels":31,"otherNames":32},"RADIATION","Subjects will be treated with low-dose radiotherapy of 300cGy in 6 fractions, 2-3 times per week on non-consecutive days.\n\nNon-responders to the initial LDRT treatment will receive a second treatment course of 300cGy in 6 fractions to be given 2-3 times per week on non-consecutive days.",[9],null,[34],{"name":35,"affiliation":5,"role":36},"Terin Sytsma, MD","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},"Tochukwu Iyke-Nzeocha","CONTACT","(507) 422-3201","Iyke-Nzeocha.Tochukwu@mayo.edu",{"name":44,"role":40,"phone":45,"phoneExt":32,"email":46},"Melissa Wang, M.A., CCRP","(507) 266-6911","wang.melissa@mayo.edu",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-92.4699,44.02163,{"lat":60,"lon":59},[63,65,66],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":64},"iyke-nzeocha.tochukwu@mayo.edu",{"name":44,"role":40,"phone":45,"phoneExt":32,"email":46},{"name":35,"role":36,"phone":32,"phoneExt":32,"email":32},{"type":36,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Terin T. Sytsma","Principal Investigator","100609655","phase-4-radiotherapy-compared-to-corticosteroid-injection-for-treatment-of-hand-osteoarthritis-100609655",false,"NCT07217405","Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis","Low-Dose Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis","Inclusion Criteria:\n\n* Patient at Mayo Clinic, Rochester, MN\n* Age 50 years or older\n* Mild, moderate, or severe hand OA (Kellgren and Lawrence classification grade 2, 3, or 4) on hand radiographs within the last 24 months\n* Hand OA pain with a minimum VAS score relating to hand pain of ≥40 (on a 100-point scale) when using the affected hand\n* Ability to complete study questionnaires\n\nExclusion Criteria:\n\n* History of previous surgery to the affected hand(s)\n* Autoimmune joint disease such as rheumatoid arthritis or psoriatic arthritis\n* Active confounding hand condition such as stenosing tenosynovitis or Dupuytren's contracture\n* Recent injury (within last 1 month) to the affected hand causing current pain\n* History of crystalline arthritis (gout or pseudogout) flare in the affected hand(s)\n* Active use of opioid pain medication(s) or oral steroids within the last 3 months\n* Fibromyalgia or central sensitization syndrome\n* Hand CSI or other hand injection within the past 3 months\n* History of hand LDRT within the past 3 months\n* Poorly controlled diabetes (HbA1c \\> 10%)\n* Active infection\n* Current pregnancy","ALL","50 Years",{"count":80,"type":81},165,"ESTIMATED","INTERVENTIONAL",[84],"PHASE4","The purpose of this research is to compare low-dose radiotherapy to corticosteroid injection for treatment of hand\u002Fwrist osteoarthritis.",[87,88],"Osteoarthritis Hand","Osteoarthritis Wrist","2026-04-21",{"date":91,"type":92},"2026-04-24","ACTUAL",{"date":94,"type":92},"2025-12-19",{"date":96,"type":81},"2027-10-01",{"name":5,"class":6},1]