[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580074":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":48,"collaborators":20,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":20,"eligibilityCriteria":56,"healthyVolunteers":53,"sex":57,"minAge":58,"maxAge":20,"enrollmentInfo":59,"targetDuration":20,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":76,"whyStopped":20,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Hopital La Rabta","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with secondary adrenal insufficiency and hypotension treated with fludrocortisone 0.05mg\u002Fd","EXPERIMENTAL","Patients with secondary adrenal insufficiency and hypotension treated with fludrocortisone 0.05mg\u002Fday during Ramadan fasting 2025.",[13],"Drug: Fludrocortisone 0.1 Milligrams (mg)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DRUG","Fludrocortisone 0.1 Milligrams (mg)","Treatment of hypotension with fludrocortisone 0.05mg\u002Fday in patients with secondary adrenal insufficiency before Ramadan fasting. Outcomes (number of fasted days and complications during fasting) will be compared between Ramadan fasting 2025 (with fludrocortisone) and Ramadan 2023 (without fludrocortisone).",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Melika Chihaoui, Professor","CONTACT","+21698647327","melika.chihaoui@fmt.utm.tn",[28],{"facility":5,"status":20,"city":29,"state":30,"zip":31,"country":30,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Tunis","Tunisia","1007","TN",{"type":34,"coordinates":35},"Point",[36,37],10.16579,36.81897,{"lat":37,"lon":36},[40,43,45],{"name":23,"role":24,"phone":41,"phoneExt":20,"email":42},"+21671150832","melikachihaoui@yahoo.fr",{"name":23,"role":44,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"name":46,"role":47,"phone":20,"phoneExt":20,"email":20},"Mariam Mabrouk, MD","SUB_INVESTIGATOR",{"type":44,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Melika Chihaoui","Professor","100580074","phase-4-ramadan-fasting-outcomes-in-patients-with-secondary-adrenal-insufficiency-before-and-after-the-treatment-of-hypotension-100580074",false,"NCT06832566","Ramadan Fasting Outcomes in Patients With Secondary Adrenal Insufficiency Before and After the Treatment of Hypotension.","Inclusion Criteria:\n\n* Patients aged over 18 years\n* Secondary adrenal insufficiency patients\n* Substituted with glucocorticoids for more than one year.\n* Participated in the former study in 2023.\n* Willing to fast during the month of Ramadan 2025.\n\nExclusion Criteria:\n\n* cardiac, respiratory, hepatic or renal insufficiency (creatinine clearance \\\u003C 60 ml\u002Fmin\u002F1.73m2), advanced neoplasia, undernutrition, diabetes insipidus, diabetes mellitus, neuro-psychiatric disease, infectious or chronic inflammatory disease, hyperthyroidism, uncontrolled hypothyroidism, alcoholism, diuretic intake, glucocorticoid treatment for purposes other than substitution, enzyme inducers, pregnancy, breastfeeding.\n* consent withdrawn, study discontinuation.","ALL","18 Years",{"count":60,"type":61},20,"ESTIMATED","INTERVENTIONAL",[64],"PHASE4","Intermittent fasting in patients with adrenal insufficiency is associated with an increased risk of complications, such as dehydration. A recent study showed that nearly half the patients had hypotension before the fasting month and half had signs of dehydration during fasting. So, we are planning to carry out this prospective interventional study in patients with SAI and hypotension to evaluate the effect of treating hypotension with fludrocortisone on the risk of complications during fasting. Patients with secondary adrenal insufficiency and hypotension and who are willing to fast during Ramadan 2025 will be included. Before Ramadan, they will be treated with fludrocortisone at a dose of 50micg\u002Fday. The occurrence of complications and the number of fasted days during Ramadan 2025 will be reported and compared with those of Ramadan 2023.",[67,68],"Secondary Adrenal Insufficiency","Hypotension",[70,71,72,73,74,75],"secondary adrenal insufficiency","intermittent fasting","complications","hypotension","fludrocortisone","quality of life","NOT_YET_RECRUITING","2025-02-12",{"date":79,"type":80},"2025-02-18","ACTUAL",{"date":82,"type":61},"2025-02-15",{"date":84,"type":61},"2025-04-15",{"name":5,"class":6},1]