[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510902":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":56,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":25,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Herlev and Gentofte Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Aspirin at bedtime","EXPERIMENTAL","Participants randomized to aspirin administration at bedtime will be instructed to take their aspirin at approx. 8PM-12AM.",[13],"Drug: Aspirin",{"label":15,"type":16,"description":17,"interventionNames":18},"Aspirin in the morning","ACTIVE_COMPARATOR","Participants randomized to aspirin administration in the morning will be instructed to take their aspirin upon awakening or with their breakfast (approx. 6-10AM).",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Aspirin","Aspirin at currently prescribed dose",[9,15],null,[27],{"name":28,"affiliation":29,"role":30},"Manan Pareek, MD, PhD","Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},"Niklas Dyrby Johansen, MD","CONTACT","+4520204794","niklas.dyrby.johansen@regionh.dk",{"name":28,"role":34,"phone":38,"phoneExt":25,"email":39},"+4525536900","mananpareek@dadlnet.dk",[41],{"facility":29,"status":42,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Hellerup","2900","Denmark","DK",{"type":48,"coordinates":49},"Point",[50,51],12.57093,55.73204,{"lat":51,"lon":50},[54,55],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},{"name":28,"role":34,"phone":38,"phoneExt":25,"email":39},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Tor Biering-Sørensen","Professor, MD, MSc, MPH, PhD","100510902","phase-4-randomized-comparison-of-morning-versus-bedtime-administration-of-aspirin-a-cardiovascular-circadian-chronotherapy-c3-trial-100510902",false,"NCT05932472","Randomized Comparison of Morning Versus Bedtime Administration of Aspirin: A Cardiovascular Circadian Chronotherapy (C3) Trial","ASPIRIN-C3","Inclusion Criteria:\n\n* Age \\>=18 years\n* Current chronic treatment with aspirin (as recorded in the Danish National Prescription Registry and confirmed by the participant via questionnaire)\n* Signed informed consent\n\nExclusion Criteria:\n\n* There are no exclusion criteria for this trial","ALL","18 Years",{"count":70,"type":71},32706,"ESTIMATED","INTERVENTIONAL",[74],"PHASE4","Wide variability in the antiplatelet effects of aspirin may lead to recurrent thromboembolic events. Several pilot studies have suggested potential benefits of taking aspirin at bedtime rather than in the morning. The primary objective of this study is to examine whether aspirin administration at bedtime versus in the morning provides a superior reduction in the incidence of major adverse cardiovascular events among patients with or without established atherosclerotic cardiovascular disease, who are already taking aspirin.",[77,78,79],"Atherosclerosis","Cardiovascular Diseases","Drug Effect",[22,81,82,83,84,85,86],"Cardiovascular Disease","Prevention","Circadian Rhythm","Randomized Controlled Trial","Pragmatic","Outcomes","2024-02-05",{"date":89,"type":90},"2024-02-06","ACTUAL",{"date":92,"type":90},"2024-01-15",{"date":94,"type":71},"2027-02-15",{"name":58,"class":6},1]