[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581935":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":59,"collaborators":63,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":24,"enrollmentInfo":74,"targetDuration":24,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":93,"whyStopped":24,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Herlev and Gentofte Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Statin at bedtime","EXPERIMENTAL","Statin in the current prescribed dose",[13],"Drug: Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)",{"label":15,"type":10,"description":11,"interventionNames":16},"Statin in the morning",[17],"Drug: Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)",[19,25],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)","Participants will be instructed to take their Statin daily at approx. 8PM-12AM.",[9],null,{"type":20,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)","Participants will be instructed to take their statin upon awakening\u002For with their breakfast (approx. 6AM-10AM).",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Manan Pareek, MD and PhD","CONTACT","+4525536900","mananpareek@dadlnet.dk",[36],{"facility":37,"status":24,"city":38,"state":24,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte","Hellerup","2900","Denmark","DK",{"type":43,"coordinates":44},"Point",[45,46],12.57093,55.73204,{"lat":46,"lon":45},[49,53,57],{"name":50,"role":32,"phone":51,"phoneExt":24,"email":52},"Sine Højlund Christensen, MSc","+4524595177","sine.hoejlund.christensen@regionh.dk",{"name":54,"role":32,"phone":55,"phoneExt":24,"email":56},"Niklas Dyrby Johansen, MD, PhD","+4520204794","niklas.dyrby.johansen@regionh.dk",{"name":31,"role":58,"phone":24,"phoneExt":24,"email":24},"PRINCIPAL_INVESTIGATOR",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Tor Biering-Sørensen","MD, PhD, MPH",[64],{"name":5,"class":6},"100581935","phase-4-randomized-comparison-of-morning-versus-bedtime-administration-of-statins-a-cardiovascular-circadian-chronotherapy-c3-trial-100581935",false,"NCT06856772","Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial","STATIN-C3","Inclusion Criteria:\n\n* Age \\>=18 years\n* Current treatment with atorvastatin 10-80 mg, rosuvastatin 5-40 mg, simvastatin 10-80 mg or pravastatin 20-40 mg (as recorded in the Danish National Prescription Registry and confirmed by the participant via questionnaire)\n* Signed informed consent\n\nExclusion Criteria:\n\n* none","ALL","18 Years",{"count":75,"type":76},42000,"ESTIMATED","INTERVENTIONAL",[79],"PHASE4","Statins inhibit hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase which catalyzes the rate-limiting step in cholesterol synthesis. This in turn leads to reductions in concentrations of low-density lipoprotein (LDL) cholesterol and C-reactive protein which reduces the risk of incident atherosclerotic events among individuals both with and without a history of atherosclerotic cardiovascular Several pilot studies have suggested potential benefits of taking statin in the evening rather than in the morning.\n\nThe primary objective of this study is to examine whether statin administration at bedtime versus in the morning provides a superior reduction in the incidence of major adverse cardiovascular events among patients with or without established atherosclerotic cardiovascular disease, who are already taking statin.",[82,83,84],"Cardiovascular Diseases (CVD)","Drug Effect","Atherosclerosis Cardiovascular Disease",[86,87,88,89,90,91,92],"Statin","Circadian Rhythm","Randomized Controlled Trial","Pragmatic","Outcomes","Cardiovascular disease","Prevention","NOT_YET_RECRUITING","2025-02-26",{"date":96,"type":97},"2025-03-04","ACTUAL",{"date":99,"type":76},"2025-02-28",{"date":101,"type":76},"2028-03-28",{"name":61,"class":6},1]