[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625002":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":40,"locations":50,"responsibleParty":246,"collaborators":248,"id":273,"slug":274,"hasResults":275,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":279,"eligibilityCriteria":280,"healthyVolunteers":275,"sex":281,"minAge":282,"maxAge":283,"enrollmentInfo":284,"targetDuration":26,"studyType":287,"phases":288,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":53,"whyStopped":26,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":312},{"fullName":5,"class":6},"Mansoura University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1, Low dose Tadalafil group","EXPERIMENTAL","Participants will receive tadalafil 5 mg orally once daily for the duration of 12 weeks",[13],"Drug: Tadalafil 5 mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Group 2: Solifenacin Group","ACTIVE_COMPARATOR","Participants will receive solifenacin succinate 5 mg orally once daily for the duration of 12 weeks",[19],"Drug: Solifenacin 5mg",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Tadalafil 5 mg","Tadalafil 5 mg orally once daily for the duration of 12 weeks",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Solifenacin 5mg","solifenacin succinate 5 mg orally once daily for the duration of 12 weeks",[15],[32,36],{"name":33,"affiliation":34,"role":35},"Ahmed A Shokeir, professor of urology","Urology & Nephrology Center, Masnoura university, Egypt","STUDY_DIRECTOR",{"name":37,"affiliation":38,"role":39},"Sherif Mourad, Professor of Urology","Ain Shams University","STUDY_CHAIR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":26,"email":45},"Mohammed Hegazy, M.D of Urology","CONTACT","+201028299216","mhalem88@yahoo.com",{"name":47,"role":43,"phone":48,"phoneExt":26,"email":49},"Yahya H ElMorsy, MSc of Urology","+201100311999","hossam.yahya@yahoo.com",[51,69,85,101,117,127,140,154,167,180,193,211,222,233],{"facility":52,"status":53,"city":54,"state":55,"zip":26,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Faculty of medicine, Menofia Univeristy","RECRUITING","Shibīn al Kawm","Al-Minūfiyyah","Egypt","EG",{"type":59,"coordinates":60},"Point",[61,62],31.00904,30.55258,{"lat":62,"lon":61},[65],{"name":66,"role":43,"phone":67,"phoneExt":26,"email":68},"Ahmed Barsim","00201096024446","ahmed.barsim@med.menofia.edu.eg",{"facility":70,"status":53,"city":71,"state":72,"zip":26,"country":56,"countryCode":57,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Faculty of medicine, Zagazig 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University, faculty of medicine","1211",{"type":59,"coordinates":215},[199,200],{"lat":200,"lon":199},[218],{"name":219,"role":43,"phone":220,"phoneExt":26,"email":221},"Hussein Aly Hussein, Professor of Urology","00201001422396","Husseinaly@kasralainy.edu.eg",{"facility":223,"status":53,"city":224,"state":26,"zip":26,"country":56,"countryCode":57,"cosmosGeoPoint":225,"geoPoint":229,"contacts":230},"Faculty of Medicine, South Valley University","Qina",{"type":59,"coordinates":226},[227,228],32.72671,26.16418,{"lat":228,"lon":227},[231],{"name":232,"role":84,"phone":26,"phoneExt":26,"email":26},"Mostafa Abdelrazek",{"facility":234,"status":53,"city":235,"state":26,"zip":26,"country":56,"countryCode":57,"cosmosGeoPoint":236,"geoPoint":240,"contacts":241},"Faculty of medicine, Sohag Univeristy","Sohag",{"type":59,"coordinates":237},[238,239],31.69478,26.55695,{"lat":239,"lon":238},[242],{"name":243,"role":43,"phone":244,"phoneExt":26,"email":245},"Ahmed Mamdouh Abdelhamed","00201068056074","sharkawiahmed@yahoo.com",{"type":247,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[249,251,252,254,257,259,261,263,265,267,269,271],{"name":250,"class":6},"Cairo University",{"name":38,"class":6},{"name":253,"class":6},"Alexandria University",{"name":255,"class":256},"Zagazig University","OTHER_GOV",{"name":258,"class":6},"Tanta University",{"name":260,"class":6},"Menoufia University",{"name":262,"class":6},"Assiut University",{"name":264,"class":6},"Sohag University",{"name":266,"class":6},"South Valley University",{"name":268,"class":6},"Beni-Suef University",{"name":270,"class":6},"Minia University",{"name":272,"class":6},"Aswan University","100625002","phase-4-randomized-controlled-trial-comparing-low-dose-tadalafil-versus-solifenacin-for-management-of-overactive-bladder-in-women-multicenter-egyptian-national-study-100625002",false,"NCT07416968","Randomized Controlled Trial Comparing Low Dose Tadalafil Versus Solifenacin For Management of Overactive Bladder in Women: Multicenter Egyptian National Study","Randomized Controlled Trial Comparing Low Dose Tadalafil Versus Solifenacin For Management of Overactive Bladder in Women: Multicenter Egyptian National Study (WoMEN'S)","WoMEN'S","Inclusion Criteria:\n\n* OAB symptoms persisting for ≥3 months\n* OAB Symptom Score (OABSS) \\> 5 and urgency sub-score of OABSS ≥ 2\n* Ability and willingness to provide informed consent.\n\nExclusion Criteria:\n\n* Active urinary tract infection.\n* Stress urinary incontinence (SUI) as primary diagnosis, or mixed urinary incontinence with predominant SUI\n* Pelvic organ prolapse stage ≥II according to POP-Q system.\n* History of pelvic radiation.\n* History of neurosurgical interventions.\n* Pregnancy or breastfeeding.\n* Neuropathic diseases affecting the lower urinary tract.\n* History of genitourinary malignancy.\n* Post-void residual urine (PVR) \\> 150 ml.\n* Vesical or lower ureteric stones.\n* Uncontrolled diabetes mellitus (HbA1c \\> 7).\n* Any psychological or psychiatric disorders.\n* Contraindications or allergy to the used medications.\n* History of surgeries in the urinary bladder.\n* History of pelvic surgeries within 6 months.\n* Voiding dysfunctions.","FEMALE","18 Years","75 Years",{"count":285,"type":286},480,"ESTIMATED","INTERVENTIONAL",[289],"PHASE4","Researchers are studying two medicines to see which works better for women with overactive bladder (OAB). OAB causes sudden urges to urinate, frequent bathroom trips, and sometimes leakage.\n\nWomen who join the study will be randomly placed into one of two groups:\n\nOne group will take tadalafil (5 mg), a medicine taken once a day.\n\nThe other group will take solifenacin (5 mg), a common treatment for OAB, also taken once a day.\n\nThe study will last 12 weeks. Participants will keep a bladder diary, answer short questionnaires, and have simple urine flow and bladder tests at several visits.\n\nThe main goal is to find out which medicine lowers OAB symptoms more, such as urgency and frequent urination. Researchers will also look at quality of life, bladder function, and side effects.\n\nWomen aged 18 to 75 years with OAB symptoms for at least 3 months may be able to take part.",[292,293],"Overactive Bladder (OAB)","Overactive Bladder Syndrome",[295,296,297,298,299,300,301,302],"Overactive Bladder","OAB","Tadalafil","Solifenacin","Low dose tadalafil","Urgency","frequency","Urge Urinary Incontinence","2026-02-17",{"date":305,"type":306},"2026-02-18","ACTUAL",{"date":308,"type":306},"2025-09-01",{"date":310,"type":286},"2026-12",{"name":5,"class":6},14]