[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565561":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":25,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":25,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Prince of Wales Hospital, Shatin, Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Denosumab group","ACTIVE_COMPARATOR","60mg subcutaneous Denosumab (1mL solution) every 6 months and intravenous placebo (100mL normal saline) once yearly",[13],"Drug: Denosumab",{"label":15,"type":16,"description":17,"interventionNames":18},"Zolendronic acid group","PLACEBO_COMPARATOR","5mg intravenous Zoledronic Acid (100mL solution) once yearly and subcutaneous placebo (1mL normal saline) every 6 months",[19],"Drug: Zolendronic Acid",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"DRUG","Denosumab",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Zolendronic Acid",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Ronald Man Yeung Wong","CONTACT","852 3505 1654","ronald.wong@cuhk.edu.hk",[36],{"facility":37,"status":38,"city":39,"state":25,"zip":25,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"The Chinese University of Hong Kong","RECRUITING","Hong Kong","China","CN",{"type":43,"coordinates":44},"Point",[45,46],114.17469,22.27832,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Ronald Man Yeung WONG","Clinical Associate Professor",[55],{"name":56,"class":6},"Chinese University of Hong Kong","100565561","phase-4-rank-ligand-inhibition-to-combat-sarcopenia-with-underlying-osteoporosis-100565561",false,"NCT06643780","RANK-ligand Inhibition to Combat Sarcopenia with Underlying Osteoporosis","RANK-ligand Inhibition to Combat Sarcopenia with Underlying Osteoporosis: a Randomized, Double-blind, Double-dummy, Active-Controlled Trial","Inclusion Criteria:\n\n* Elderly males or females aged 65 years or older\n* diagnosed with osteosarcopenia (sarcopenia diagnosis based on AWGS 2019 guidelines - low appendicular skeletal muscle mass (ASM) by Dual-energy X-ray absorptiometry (DXA) (M:\\<7.0kg\u002Fm2, F:\\<5.4kg\u002Fm2) AND low handgrip strength (M:\\<28kg, F:\\<18kg) OR low physical performance (6-metre walk: \\<1.0m\u002Fs or 5-time chair stand test ≥ 12 s); osteoporosis diagnosed based on World Health Organization (WHO) criteria with DXA scan T-score ≤ -2.5)\n* Willing and able to comply with study protocol including follow-up evaluations.\n\nExclusion Criteria:\n\n* history of recent fracture i.e., within 3 months\n* history of prior anti-osteoporotic drug\n* disease or medication affecting bone or muscle metabolism\n* Chairbound or bedbound\n* Unable to agree for consent\n* contraindication to drug i.e., Denosumab or Zoledronic Acid\n* Underlying malignancy or disease known to cause cachexia\n* severe renal impairment e.g., Creatinine Clearance (CrCl) \\< 35ml\u002Fmin\n* moderate to severe liver failure (Child-Pugh Class B or C).","ALL","65 Years",{"count":67,"type":68},120,"ESTIMATED","INTERVENTIONAL",[71],"PHASE4","The objective of this study was to conduct a randomized, double-blind, double-dummy active controlled trial to determine the efficacy of denosumab in treating sarcopenia with underlying osteoporosis.",[74],"Sarcopenia in Elderly","2024-10-13",{"date":77,"type":78},"2024-10-16","ACTUAL",{"date":80,"type":78},"2024-04-09",{"date":82,"type":68},"2027-10",{"name":5,"class":6},1]