[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630254":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":72,"collaborators":75,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":11,"enrollmentInfo":90,"targetDuration":11,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":58,"whyStopped":11,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Herlev and Gentofte Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Recombinant Herpes Zoster Vaccine (Shingrix).","EXPERIMENTAL",null,[13],"Biological: Recombinant Herpes Zoster Vaccine (Shingrix)",{"label":15,"type":16,"description":17,"interventionNames":11},"No Herpes Zoster vaccine (control)","NO_INTERVENTION","Control arm, no intervention.",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"BIOLOGICAL","Recombinant Herpes Zoster Vaccine (Shingrix)","Two doses of Shingrix vaccine spaced 2-6 months apart.",[9],[25],{"name":26,"affiliation":27,"role":28},"Tor Biering-Sørensen, MD, PhD, MSc, MPH","Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte","STUDY_CHAIR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Daniel Modin, MD","CONTACT","+4541828993","danielmodin.md@gmail.com",{"name":26,"role":32,"phone":36,"phoneExt":11,"email":37},"+4528933590","tor.biering-soerensen@regionh.dk",[39,56],{"facility":27,"status":40,"city":41,"state":11,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"NOT_YET_RECRUITING","Hellerup","2900","Denmark","DK",{"type":46,"coordinates":47},"Point",[48,49],12.57093,55.73204,{"lat":49,"lon":48},[52,53],{"name":26,"role":32,"phone":36,"phoneExt":11,"email":37},{"name":54,"role":55,"phone":11,"phoneExt":11,"email":11},"Tor Biering-Sørensen","PRINCIPAL_INVESTIGATOR",{"facility":57,"status":58,"city":59,"state":11,"zip":11,"country":43,"countryCode":44,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Danske Lægers Vaccinations Service","RECRUITING","Søborg",{"type":46,"coordinates":61},[62,63],12.31803,56.08481,{"lat":63,"lon":62},[66,70],{"name":67,"role":32,"phone":68,"phoneExt":11,"email":69},"Carsten Schade Larsen, MD, DMSc","+4540459708","carsten.schade.larsen@dadlnet.dk",{"name":71,"role":55,"phone":11,"phoneExt":11,"email":11},"Carsten Schade Larsen, MD",{"type":73,"investigatorFullName":54,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"SPONSOR_INVESTIGATOR","Professor",[76],{"name":77,"class":78},"GlaxoSmithKline","INDUSTRY","100630254","phase-4-recombinant-herpes-zoster-vaccine-for-prevention-of-cardiovascular-events-and-dementia-100630254",false,"NCT07485283","Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia","A Pragmatic Randomized Trial to Evaluate the Effect of Recombinant Herpes Zoster Vaccine on Major Adverse Cardiovascular Events and Dementia in Adults Aged 65 Years or Above","DAN-ZOSTER","Inclusion Criteria:\n\n1. Age 65 years and above at the time of consent\n2. Self-reported ability to understand written and spoken Danish or English\n3. Informed consent form has been signed and dated\n\nExclusion Criteria:\n\nThe study has the following exclusion criteria which will be assessed through self-reporting:\n\n1. A prior diagnosis of dementia\n2. Chronic inflammatory rheumatic disease and concomitant immunosuppressive therapy\n3. Prior herpes zoster vaccination",true,"ALL","65 Years",{"count":91,"type":92},162000,"ESTIMATED","INTERVENTIONAL",[95],"PHASE4","DAN-ZOSTER is a nationwide randomized study investigating whether vaccination against herpes zoster (shingles) can reduce the risk of cardiovascular disease and dementia in older adults. Herpes zoster is caused by reactivation of the varicella-zoster virus and becomes more common with increasing age. Some observational studies have suggested that vaccination against herpes zoster may also lower the risk of heart attacks, strokes, and dementia, but this has not been confirmed in randomized clinical trials.\n\nIn this study, approximately 162,000 adults aged 65 years or older living in Denmark will be randomly assigned to either receive the recombinant herpes zoster vaccine (Shingrix®) or receive no vaccine. Participants in the vaccine group will receive two doses given 2-6 months apart.\n\nParticipants will be identified and invited using Danish national registries and digital mail systems. Information about health outcomes will be collected through nationwide health registries during follow-up.\n\nThe main outcomes of the study are major cardiovascular events (heart attack, stroke, or cardiovascular death) and new diagnoses of dementia. The goal of the study is to determine whether herpes zoster vaccination can help prevent these conditions in older adults.",[98,99],"Cardiovascular Disease","Dementia",[101,102,103,104,105,106,107,108,109,110,111],"herpes zoster","dementia","myocardial infarction","stroke","cardiovascular death","pragmatic","registry","vaccination","herpes zoster vaccine","shingles","randomized trial","2026-04-28",{"date":114,"type":115},"2026-05-04","ACTUAL",{"date":112,"type":115},{"date":118,"type":92},"2029-04",{"name":54,"class":6},2]