[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631530":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":42,"responsibleParty":59,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":26,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":87,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Rutgers, The State University of New Jersey","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tranexamic Acid (TXA)","EXPERIMENTAL","Participants undergoing urethroplasty will receive tranexamic acid (TXA) administered perioperatively in addition to standard surgical care.",[13],"Drug: Tranexamic Acid",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard of Care (No TXA)","ACTIVE_COMPARATOR","Participants undergoing urethroplasty will receive standard surgical care without tranexamic acid.",[19],"Procedure: Urethroplasty",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Tranexamic Acid","Tranexamic acid (TXA) will be administered perioperatively according to institutional protocol to reduce intraoperative and postoperative bleeding.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Urethroplasty","Surgical urethral reconstruction performed according to standard institutional techniques.",[15],[33],{"name":34,"affiliation":35,"role":36},"Amjad Alwaal, MD, MSc, FACS","Rutgers University","PRINCIPAL_INVESTIGATOR",[38],{"name":34,"role":39,"phone":40,"phoneExt":26,"email":41},"CONTACT","973-972-4418","amjad.alwaal@rutgers.edu",[43],{"facility":44,"status":26,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"University Hospital","Newark","New Jersey","07103","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-74.17237,40.73566,{"lat":54,"lon":53},[57],{"name":58,"role":39,"phone":40,"phoneExt":26,"email":41},"Amjad Alwaal, MD",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Amjad Alwaal, MD, MSc, FRCSC, FACS","Associate Professor of Urology","100631530","phase-4-reducer-trial-txa-in-urethroplasty-100631530",false,"NCT07501884","REDUCER Trial (TXA in Urethroplasty)","Reduction of Perioperative Blood Loss in Urethral Reconstruction Using Tranexamic Acid (REDUCER Trial): A Multicenter Pragmatic Randomized Study","REDUCER","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Undergoing urethroplasty for urethral stricture disease\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known contraindication to tranexamic acid (TXA)\n* History of thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism, stroke)\n* Known bleeding disorder or coagulopathy\n* Current use of anticoagulation that cannot be safely held perioperatively\n* Severe renal impairment\n* Allergy or hypersensitivity to tranexamic acid\n* History of seizures\n* Inability to provide informed consent","MALE","18 Years",{"count":74,"type":75},40,"ESTIMATED","INTERVENTIONAL",[78],"PHASE4","This study will test whether tranexamic acid (TXA), a medication used to reduce bleeding, can decrease blood loss in patients having urethroplasty. Participants will be randomly assigned to receive either a single intravenous dose of TXA at the start of anesthesia or standard care without TXA. Researchers will compare hemoglobin change after surgery as well as estimated blood loss and complications.",[81,82],"Urethral Stricture","Urethral Diseases",[23,29,84,85,86],"Blood Loss","Hemoglobin","Reconstructive Urology","NOT_YET_RECRUITING","2026-03-25",{"date":90,"type":91},"2026-03-30","ACTUAL",{"date":93,"type":75},"2026-05-01",{"date":95,"type":75},"2027-03-30",{"name":61,"class":6},1]