[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577459":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":41,"centralContacts":46,"locations":54,"responsibleParty":73,"collaborators":33,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":33,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":33,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":57,"whyStopped":33,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Penn State University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Premenopausal estrogen suppression","EXPERIMENTAL","Participants take a cellulose placebo tablet for 4 days prior to baseline testing and continue until experimental visits are complete. Following completion of placebo testing, participants begin taking 400 mg\u002Fday Elagolix for 4 days prior to testing and continue until experimental visits are complete.",[13,14],"Drug: Elagolix Oral Tablet","Other: cellulose placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"Postmenopausal estrogen supplementation","Participants wear a transdermal estradiol patch or placebo patch for 5 days prior to testing and continue until experimental visits are complete. After 48 hr washout, participants then wear the alternative treatment for 5 days prior to testing until experimental visits are complete.",[19,20],"Drug: Estradiol patch","Other: placebo patch",[22,29,34,38],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","Elagolix Oral Tablet","2 x 200 mg tablet",[9],[28],"Orilissa",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Estradiol patch","0.05 mg\u002Fday patch",[16],null,{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"cellulose placebo","placebo tablet",[9],{"type":6,"name":39,"description":39,"armGroupLabels":40,"otherNames":33},"placebo patch",[16],[42],{"name":43,"affiliation":44,"role":45},"W. Larry Kenney, Ph.D.","The Pennsylvania State University","PRINCIPAL_INVESTIGATOR",[47,51],{"name":43,"role":48,"phone":49,"phoneExt":33,"email":50},"CONTACT","814-863-1672","w7k@psu.edu",{"name":52,"role":48,"phone":33,"phoneExt":33,"email":53},"Olivia K. Leach, MS","okl5046@psu.edu",[55],{"facility":56,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Noll Laboratory","RECRUITING","University Park","Pennsylvania","16802","United States","US",{"type":64,"coordinates":65},"Point",[66,67],-77.85639,40.80201,{"lat":67,"lon":66},[70,71],{"name":43,"role":48,"phone":49,"phoneExt":33,"email":50},{"name":72,"role":48,"phone":33,"phoneExt":33,"email":53},"Olivia Leach, MS",{"type":45,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"W. Larry Kenney","Professor","100577459","phase-4-role-of-menopause-in-thermoregulation-100577459",false,"NCT06798571","Role of Menopause in Thermoregulation","The Influence of Estrogen on the Thermoregulatory Responses to Heat Stress in Pre and Postmenopausal Women","Inclusion Criteria:\n\n* Women ages 42-64\n\nExclusion Criteria:\n\n* Chron's disease, diverticulitis, or similar gastrointestinal disease\n* Abnormal resting exercise electrocardiogram (ECG)\n* Tobacco use\n* High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor\n* Assessment\n* Using hormone therapy\n* Using hormonal contraceptives",true,"FEMALE","42 Years","64 Years",{"count":88,"type":89},24,"ESTIMATED","INTERVENTIONAL",[92],"PHASE4","The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men.\n\nAging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.",[95,96],"Menopause","Aging",[98,99],"Thermoregulation","Heat Stress","2026-06-23",{"date":102,"type":103},"2026-06-24","ACTUAL",{"date":105,"type":103},"2025-03-01",{"date":107,"type":89},"2026-09-01",{"name":5,"class":6},1]