[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549028":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":61,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":26,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Virginia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"TXA group","EXPERIMENTAL","Women undergoing immediate or delayed free flap breast reconstruction and receiving IV TXA",[13],"Drug: Tranexamic acid",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo group","PLACEBO_COMPARATOR","Women undergoing immediate or delayed free flap breast reconstruction and receiving same volume of IV saline",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Tranexamic acid","Experimental group will receive TXA intraoperatively (15mg\u002Fkg IV, once at beginning of case then re dose at 4hrs if operation goes longer) at the time of their surgery.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Control group will receive same volume equivalent of saline intravenously at the time of their surgery.",[15],[32],{"name":33,"affiliation":5,"role":34},"John Stranix, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Rachel Park, MD","CONTACT","5714287278","RHP7GU@uvahealth.org",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"University of Virginia Medical Center","RECRUITING","Charlottesville","Virginia","22902","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-78.47668,38.02931,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":59,"phoneExt":26,"email":60},"Rachel H Park, MD","571-428-7278","rhp7gu@hscmail.mcc.virginia.edu",{"type":34,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"John Stranix","Assistant Professor of Plastics Surgery","100549028","phase-4-role-of-txa-in-patients-undergoing-breast-free-flap-reconstruction-100549028",false,"NCT06428682","Role of TXA in Patients Undergoing Breast Free Flap Reconstruction","Role of Intravenous Tranexamic Acid Use in Patients Undergoing Breast Free Flap Reconstruction: Randomized Controlled Trial","Inclusion Criteria:\n\n* All female patients who are 18 years or older who will undergo unilateral or bilateral abdomen-based free flap breast reconstruction at UVA Medical Center\n\nExclusion Criteria:\n\n* Subjects with ages \\\u003C18 years\n* Allergy to TXA\n* Subjects who has contraindications to TXA: anyone who has active intravascular thrombosis or anyone with subarachnoid hemorrhage\n* Subjects who have anemia (defined as baseline hemoglobin \\\u003C8 g\u002FdL\n* Subjects who cannot read or understand English\n* Subjects who are pregnant","FEMALE","18 Years",{"count":74,"type":75},100,"ESTIMATED","INTERVENTIONAL",[78],"PHASE4","Tranexamic acid (TXA) is a synthetic, competitive lysine receptor inhibitor on plasminogen. It ultimately stabilizes the fibrin matrix, therefore used as a hemostatic agent for various indications. While there has been indications for orthopedic and trauma surgery, there is no clear data for its role in patients who are undergoing free tissue transfer. Studies have shown that patients undergoing free tissue transfer can have transfusion rates ranging from 7.2% to 34.9%, which data also showing association between transfusion requirement and higher free flap failure rate. There has been a few retrospective studies that evaluated the effect of TXA in free tissue transfer and the results showed no increased risk of microanastomosis failure but some showing decreased blood loss. This study aims to further analyze the role of TXA in patients undergoing breast free flap reconstruction with randomized, prospective trial. Control group will not receive TXA while experimental group will receive TXA. Both groups will receive standard of care breast free flap surgery as well as post-op care, which is streamlined with Early Recovery After Surgery (ERAS) protocol. Their pre and post-op hemoglobin will be compared, as well as rates of transfusion, surgical outcome and surgical complications including hematoma, flap failure, and any other medical complications such as Deep Vein Thrombosis (DVT)\u002F Pulmonary Embolism (PE).",[81,82],"Breast Cancer","Blood Loss, Surgical",[84,85,86],"Autologous breast reconstruction","Free Flap","Tranexamic Acid","2024-06-03",{"date":89,"type":90},"2024-06-05","ACTUAL",{"date":92,"type":90},"2024-05-13",{"date":94,"type":75},"2026-05-13",{"name":5,"class":6},1]