[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612377":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":27,"locations":33,"responsibleParty":52,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":26,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":36,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Sao Paulo General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ARDs","EXPERIMENTAL","PCV20 (Prevenar 20) vaccine administered intramuscularly in 1 dose depending on age and prior vaccination history.",[13],"Biological: Pneumococcal Vaccine",{"label":15,"type":16,"description":11,"interventionNames":17},"Healthy control","ACTIVE_COMPARATOR",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BIOLOGICAL","Pneumococcal Vaccine","0.5 mL intramuscular dose containing polysaccharide conjugates for 20 pneumococcal serotypes (PCV20, Prevenar 20) vaccine will be administered intramuscularly in 1 dose in patients with ARDs and healthy controls.",[9,15],[25],"20-valent pneumococcal conjugate vaccine",null,[28],{"name":29,"role":30,"phone":31,"phoneExt":26,"email":32},"Clovis A Silva, Full Professor","CONTACT","(11) 2661-6105","reumatologia.fmusp@hc.fm.usp.br",[34],{"facility":35,"status":36,"city":37,"state":37,"zip":26,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Hospital das Clinics da Faculdade de Medicina da Universidade de Sao Paulo","RECRUITING","São Paulo","Brazil","BR",{"type":41,"coordinates":42},"Point",[43,44],-46.63611,-23.5475,{"lat":44,"lon":43},[47],{"name":48,"role":30,"phone":49,"phoneExt":50,"email":51},"Luisa Forero, MD","1130617490","+55","luisa.forero@hc.fm.usp.br",{"type":53,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[55],{"name":56,"class":57},"Insituto Adolfo Lutz","UNKNOWN","100612377","phase-4-safety-and-immunogenicity-of-pcv20-in-pediatric-patients-with-autoimmune-rheumatic-diseases-100612377",false,"NCT07252791","Safety and Immunogenicity of PCV20 in Pediatric Patients With Autoimmune Rheumatic Diseases","Safety and Immunogenicity of the 20-valent Pneumococcal Conjugate Vaccine (PCV20) in Children and Adolescents With Autoimmune Rheumatic Diseases","PCV20-PARD","Inclusion Criteria:\n\n* Age 2-25 years\n* Diagnosis of JIA, jSLE, or JDM by validated classification criteria\n* Clinically stable\n* Informed consent\u002Fassent\n\nExclusion Criteria:\n\n* Acute infection or fever at vaccination\n* Severe allergic reaction to vaccine components\n* Recent blood transfusion (\\\u003C6 months)\n* Other vaccine within 4 weeks prior at the time of inclusion\n* Pregnancy or breastfeeding\n* Prior PCV20",true,"ALL","2 Years","25 Years",{"count":71,"type":72},114,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","This clinical trial evaluates the immunogenicity (humoral and cellular) and safety of the 20-valent pneumococcal conjugate vaccine (PCV20) in children, adolescents, and young adults aged 2-25 years with autoimmune rheumatic diseases (ARDs). All participants will receive PCV20 according to prior vaccine history. Antibody titers, opsonophagocytic activity, cellular immune responses, and adverse events will be measured up to 6 months post-vaccination. Effects of immunosuppressive therapy and physical activity levels related vaccine response will also be assessed.",[78],"Autoimmune Rheumatologic Disease",[80,81,82,83,84,85],"Pneumococcal Conjugate Vaccine","PCV20","Autoimmune Diseases","Pediatric Rheumatology","Immunogenicity","Vaccine Safety","2026-03-02",{"date":88,"type":89},"2026-03-04","ACTUAL",{"date":91,"type":89},"2026-01-16",{"date":93,"type":72},"2027-12-30",{"name":5,"class":6},1]