[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553445":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":38,"responsibleParty":62,"collaborators":12,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":12,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":12,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":12,"overallStatus":84,"whyStopped":12,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Rush University Medical Center","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Unresolved Deep Venous Thrombosis Patients continuing with systemic anticoagulation","NO_INTERVENTION","Patients presenting to emergency department with the following criteria:\n\nover 18 years of age, who have diagnosis of acute femoropopliteal acute deep venous thrombus, placed on anticoagulation treatment and failed to resolve the DVT in 1 week (+\u002F- 3 days) follow up Doppler US study. In control arm the treatment will be the continuation of current anticoagulation treatment, which is standard of care for 12 months unless crossover between groups is needed.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Unresolved Deep Venous Thrombosis Patients managed by interventional therapies.","EXPERIMENTAL","Patients presenting to emergency department with the following criteria:\n\nover 18 years of age, who have diagnosis of acute femoropopliteal acute deep venous thrombus, placed on anticoagulation treatment and failed to resolve the DVT in 1 week (+\u002F- 3 days) follow up Doppler US study. In intervention arm, patients will undergo either CDT or MT procedures both of which have been cleared by FDA for the treatment of acute DVT. FDA-cleared endovascular devices currently available at our institution will be used for both procedures. The choice of procedure will be based on operator's preference, availability of device and the patient's bleeding risk. The endovascular procedure will be scheduled within 15 days of the initial symptoms.",[18],"Other: Thrombolysis\u002FThrombectomy",[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"Thrombolysis\u002FThrombectomy","Endovascular interventions will be either catheter directed thrombolysis or mechanical thrombectomy procedures both of which have been cleared by FDA for the treatment of acute DVT.\n\nCatheter-directed thrombolysis involves the use of a catheter to deliver thrombolytic agents directly to the site of the clot, effectively dissolving the thrombus. Mechanical thrombectomy, on the other hand, employs specialized devices to physically remove the clot from the vessel. These procedures have been cleared by FDA as they are targeted approaches to safely and effectively restore blood flow and reduce the risk of complications associated with acute DVT.",[14],[25],{"name":26,"affiliation":5,"role":27},"Bulent Arslan, MD","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},"Emerald Amos, MS","CONTACT","312-947-2518","Emerald_Amos@rush.edu",{"name":35,"role":31,"phone":36,"phoneExt":12,"email":37},"Okan Ince, MS","312-947-2508","Okan_Ince@rush.edu",[39],{"facility":40,"status":12,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RUSH University Medical Center","Chicago","Illinois","60612","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-87.65005,41.85003,{"lat":50,"lon":49},[53,55,56,57,60],{"name":54,"role":31,"phone":36,"phoneExt":12,"email":37},"Okan Ince, MD",{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},{"name":26,"role":27,"phone":12,"phoneExt":12,"email":12},{"name":58,"role":59,"phone":12,"phoneExt":12,"email":12},"Lisa Rauschert, MD","SUB_INVESTIGATOR",{"name":61,"role":59,"phone":12,"phoneExt":12,"email":12},"Rehan Riaz, MD",{"type":27,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Bulent Arslan","Physician","100553445","phase-4-second-line-endovascular-treatment-in-acute-dvt-100553445",false,"NCT06486181","Second Line Endovascular Treatment in Acute DVT","A Randomized Controlled Trial for Second Line Treatment of Acute DVT With Endovascular Interventional Treatments","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients who have diagnosis of acute femoropopliteal acute deep venous thrombus\n* Patients eligible for anticoagulation treatment\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Patients over 75 years of age\n* Symptoms starting date of more than 14 days\n* Patients who have contraindication for anticoagulation treatment\n* Patients who have high bleeding risk (more than 2 of the following risk factors):\n\n  * Age \\>65 years\n  * Previous bleeding\n  * Cancer\n  * Metastatic cancer\n  * Renal failure\n  * Liver failure\n  * Thrombocytopenia\n  * Previous stroke\n  * Diabetes\n  * Anemia\n  * Antiplatelet therapy\n  * Poor anticoagulant control\n  * Comorbidity and reduced functional capacity\n  * Recent surgery in 30 days\n  * Frequent falls\n* Hemodynamically unstable patients\n* Patients having severe swelling and pain, cyanosis, and absent pulses consistent with compartment syndrome.","ALL","18 Years","75 Years",{"count":76,"type":77},100,"ESTIMATED","INTERVENTIONAL",[80],"PHASE4","The goal of this study is to fill the paucity of second line endovascular treatment for acute deep venous thrombus (DVT) by using catheter-directed thrombolysis (CDT) and mechanical thrombectomy (MT) as adjunctive second-line treatments for acute DVT patients who show no improvement after an initial anticoagulation trial for one week. The main questions the study aims to answer are:\n\n\\- Are adjunctive use of endovascular interventional treatments as second-line to DVT treatment safe and efficient?\n\nParticipants will be followed with repeat US at 1 week after initial DVT to assess for response to anticoagulation treatment. If there is significant residual thrombus with minimal or no response to treatment, participants will be offered enrollment to the study in the office or inpatient setting. Enrolled participants will be randomized into control or intervention arms with 1:1 ratio. Researchers will compare follow-up Villalta and Marder scores between groups to see whether endovascular interventions are safe and efficient.",[83],"Deep Venous Thrombosis","NOT_YET_RECRUITING","2026-01-26",{"date":87,"type":88},"2026-01-28","ACTUAL",{"date":90,"type":77},"2026-04-01",{"date":92,"type":77},"2029-04-30",{"name":5,"class":6},1]