[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100293896":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":44,"centralContacts":49,"locations":59,"responsibleParty":79,"collaborators":38,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":38,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":38,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":62,"whyStopped":38,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Queen's University","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Cough Variant Asthma","EXPERIMENTAL","Individuals diagnosed with Cough variant asthma",[13,14,15],"Drug: Methacholine (MCh) Challenge Testing","Diagnostic Test: Eucapneic Voluntary Hyperventilation (EVH)","Drug: Mannitol Inhalation Kit",{"label":17,"type":10,"description":18,"interventionNames":19},"Methacholine-induced cough","Individuals with chronic cough and negative methacholine challenge",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Control","Individuals with no history of asthma or chronic cough",[13,14,15],[25,33,39],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Methacholine (MCh) Challenge Testing","Visit 1: Informed consent, Baseline screening and pulmonary function tests and Low-dose methacholine challenge testing using partial and full flow-volume loops.",[21,9,17],[31,32],"MCh[inhalation of sequential doubling doses of MCh(0.0625-16 mg\u002FmL)]","Provocholine",{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"DIAGNOSTIC_TEST","Eucapneic Voluntary Hyperventilation (EVH)","Visit 2 or 3: Will be conducted in random order and subjects will perform one of the two challenge tests at either visit.",[21,9,17],null,{"type":26,"name":40,"description":36,"armGroupLabels":41,"otherNames":42},"Mannitol Inhalation Kit",[21,9,17],[43],"Mannitol Challenge Test",[45],{"name":46,"affiliation":47,"role":48},"M. Diane Lougheed, MD, MSc","Department of Medicine, Queen's University","PRINCIPAL_INVESTIGATOR",[50,54],{"name":46,"role":51,"phone":52,"phoneExt":38,"email":53},"CONTACT","613-548-2348","diane.lougheed@kingstonhsc.ca",{"name":55,"role":51,"phone":56,"phoneExt":57,"email":58},"Taylar Wall, RRT","613-549-6666","2798","taylar.wall@kingstonhsc.ca",[60],{"facility":61,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Kingston Health Sciences Centre","RECRUITING","Kingston","Ontario","K7L 2V7","Canada","CA",{"type":69,"coordinates":70},"Point",[71,72],-76.48098,44.22976,{"lat":72,"lon":71},[75,77],{"name":76,"role":51,"phone":56,"phoneExt":57,"email":58},"Taylar Wall",{"name":78,"role":48,"phone":38,"phoneExt":38,"email":38},"M Diane Lougheed, MD MSc",{"type":80,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"SPONSOR_INVESTIGATOR","Dr. Diane Lougheed","Professor of Medicine","100293896","phase-4-sensory-mechanical-responses-to-eucapneic-voluntary-hyperventilation-and-mannitol-100293896",false,"NCT03105843","Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol","Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol in Individuals With Cough Variant Asthma and Chronic Cough","Inclusion Criteria:\n\n* Individuals aged 18-65 years of age with CVA and individuals with methacholine-induced cough but normal airway sensitivity. The following definitions will be used:\n\n  1. CVA: chronic cough (≥8 weeks) is the sole or predominant symptom and positive methacholine challenge (PC20 ≤ 16 mg\u002FmL) and history of cough responding to specific asthma treatment (such as inhaled steroid or 1 week trial of bronchodilator);\n  2. Methacholine-induced cough but normal airway sensitivity: chronic cough (≥8 weeks) is the sole or predominant symptom and negative methacholine challenges (PC20 \\> 16 mg\u002FmL).\n* Individuals aged 18-65 years of age with no history of asthma or chronic cough.\n\nExclusion Criteria:\n\n* an exacerbation necessitating a change in medication, emergency department visit or hospitalizations within the previous 4 weeks\n* inability to perform acceptable spirometry\n* medical contraindications to methacholine challenge testing\n* smoking history in excess of 10 pack years Note: Previous treatment with inhaled or systemic corticosteroids is not an exclusion criterion; medication use will be recorded and examined in the analysis.",true,"ALL","18 Years","65 Years",{"count":95,"type":96},30,"ESTIMATED","INTERVENTIONAL",[99],"PHASE4","The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough.\n\nWe hypothesize:\n\n1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls.\n2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).",[102,103,9],"Asthma","Cough",[102,103,105,106],"Eucapneic Voluntary Hyperventilation","Hypertonic Saline","2025-03-17",{"date":109,"type":110},"2025-03-20","ACTUAL",{"date":112,"type":110},"2022-03-01",{"date":114,"type":96},"2026-06-30",{"name":81,"class":6},1]