[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637887":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":53,"collaborators":26,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":26,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":26,"enrollmentInfo":66,"targetDuration":26,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":26,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Atlantic Health System","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Silodosin","EXPERIMENTAL","Silodosin 8mg PO daily",[13],"Drug: Silodosin 8 mg",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Identical placebo capsule, 1 capsule PO daily",[19],"Drug: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Silodosin 8 mg","Silodosin 8mg PO qd x8 weeks",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Identical placebo capsule, 1 capsule PO daily x8 weeks",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},"Mariah McKevitt, MD","CONTACT","973-971-7267","mariah.mckevitt@atlantichealth.org",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Atlantic Health","RECRUITING","Morristown","New Jersey","07960","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-74.48154,40.79677,{"lat":49,"lon":48},[52],{"name":32,"role":33,"phone":34,"phoneExt":26,"email":35},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Carolyn Botros","Urogynecologist","100637887","phase-4-silodosin-for-urinary-symptoms-in-female-patients-with-multiple-sclerosis-100637887",false,"NCT07614321","Silodosin for Urinary Symptoms in Female Patients With Multiple Sclerosis","Is Silodosin Effective for Treating Lower Urinary Tract Symptoms in Female Patients With Multiple Sclerosis? A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Female patients with a diagnosis of multiple sclerosis\n2. Age \\> 18\n3. Moderate to severe lower urinary tract symptoms as defined by an AUASS score \\> 8\n4. No UTI\n\nExclusion Criteria:\n\n1. Treatment with alpha-blocker, B3 agonist, or anticholinergic medication within the last 6 weeks\n2. Treatment with sacral neuromodulation, bladder Botox, or posterior tibial nerve stimulation within the last 9 months\n3. Renal impairment with CrCl \\\u003C 30\n4. PVR \\> 300\n5. Diagnosed orthostatic hypotension\n6. Pregnancy or breastfeeding\n7. Severe liver impairment (Child-Pugh class C)\n8. Current symptomatic kidney stones\n9. Recent MS relapse within the last 3 months\n10. Recent treatment with steroids in the last 3 months (this does not include one-time pre-treatment with steroids for administration of immunologic drug)","FEMALE","18 Years",{"count":67,"type":68},60,"ESTIMATED","INTERVENTIONAL",[71],"PHASE4","The goal of this clinical trial is to learn if silodosin works to treat lower urinary tract symptoms (LUTS) in female patients with multiple sclerosis (MS). It will also learn about the effect of the drug on voiding parameters. The main questions it aims to answer are:\n\nDoes silodosin improve lower urinary tract symptoms based on questionnaires? Does silodosin change Uroflowmetry parameters in female patients with MS? Researchers will compare silodosin to a placebo (a look-alike substance that contains no drug) to see if silodosin works to treat LUTS in female patients with MS.\n\nParticipants will:\n\nTake silodosin or a placebo every day for 8 weeks Visit the clinic before initiating the medication and after 8 weeks of taking the medication for questionnaires and tests",[74,75],"Multiple Sclerosis","Lower Urinary Track Symptoms","2026-05-26",{"date":78,"type":79},"2026-05-29","ACTUAL",{"date":81,"type":68},"2026-04",{"date":83,"type":68},"2028-04",{"name":5,"class":6},1]