[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100448026":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":38,"locations":47,"responsibleParty":247,"collaborators":249,"id":263,"slug":264,"hasResults":265,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":269,"eligibilityCriteria":270,"healthyVolunteers":265,"sex":271,"minAge":272,"maxAge":273,"enrollmentInfo":274,"targetDuration":26,"studyType":277,"phases":278,"briefSummary":280,"conditions":281,"keywords":287,"overallStatus":50,"whyStopped":26,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":312},{"fullName":5,"class":6},"McMaster University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Single-Dose Celestone","EXPERIMENTAL","Having already received the first dose of Celestone as part of eligibility criteria, participants randomized to the experimental \"Single-Dose\" arm will receive a similar appearing placebo injection.",[13],"Drug: Celestone + placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Double-Dose Celestone","ACTIVE_COMPARATOR","Having already received the first dose of Celestone as part of eligibility criteria, participants randomized to the \"Double-Dose\" arm will receive the standard 2nd dose of Celestone injected intramuscularly (i.e. they will receive the standard double-dose regimen).",[19],"Drug: Celestone + Celestone",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Celestone + placebo","After the first intramuscular injection of Celestone, participants randomized to the \"Placebo Comparator\" group will receive 1 intramuscular injection of placebo.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Celestone + Celestone","After the first intramuscular injection of Celestone, participants randomized to the \"Active Comparator\" group will receive 1 intramuscular injection of Celestone.",[15],[32,35],{"name":33,"affiliation":5,"role":34},"Sarah D McDonald, MD,MSc,FRCSC","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":37,"role":34},"Kellie Murphy, MD,MSc,FRCSC","University of Toronto",[39,44],{"name":33,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","905-525-9140","26622","mcdonals@mcmaster.ca",{"name":45,"role":40,"phone":26,"phoneExt":26,"email":46},"SNACS Coordinating Centre","SNACS@sunnybrook.ca",[48,61,69,79,87,95,103,112,117,126,134,143,152,160,168,176,184,192,197,207,212,217,222,230,238],{"facility":49,"status":50,"city":51,"state":52,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":26},"University of Calgary, Cumming School of Medicine","RECRUITING","Calgary","Alberta","Canada","CA",{"type":56,"coordinates":57},"Point",[58,59],-114.08529,51.05011,{"lat":59,"lon":58},{"facility":62,"status":50,"city":63,"state":52,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":64,"geoPoint":68,"contacts":26},"Alberta Health Services; University of Alberta","Edmonton",{"type":56,"coordinates":65},[66,67],-113.46871,53.55014,{"lat":67,"lon":66},{"facility":70,"status":71,"city":72,"state":73,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":74,"geoPoint":78,"contacts":26},"Royal Columbian Hospital","NOT_YET_RECRUITING","New Westminster","British Columbia",{"type":56,"coordinates":75},[76,77],-122.91092,49.20678,{"lat":77,"lon":76},{"facility":80,"status":71,"city":81,"state":73,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":82,"geoPoint":86,"contacts":26},"Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre","Surrey",{"type":56,"coordinates":83},[84,85],-122.82509,49.10635,{"lat":85,"lon":84},{"facility":88,"status":71,"city":89,"state":73,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":90,"geoPoint":94,"contacts":26},"University of British Columbia; BC Women's Hospital","Vancouver",{"type":56,"coordinates":91},[92,93],-123.11934,49.24966,{"lat":93,"lon":92},{"facility":96,"status":71,"city":97,"state":73,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":98,"geoPoint":102,"contacts":26},"Victoria General Hospital","Victoria",{"type":56,"coordinates":99},[100,101],-123.35155,48.4359,{"lat":101,"lon":100},{"facility":104,"status":71,"city":105,"state":106,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":107,"geoPoint":111,"contacts":26},"University of Manitoba, Health Sciences Centre","Winnipeg","Manitoba",{"type":56,"coordinates":108},[109,110],-97.14704,49.8844,{"lat":110,"lon":109},{"facility":113,"status":71,"city":105,"state":106,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":114,"geoPoint":116,"contacts":26},"University of Manitoba; St. Boniface General Hospital",{"type":56,"coordinates":115},[109,110],{"lat":110,"lon":109},{"facility":118,"status":50,"city":119,"state":120,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":121,"geoPoint":125,"contacts":26},"Dr. Everett Chalmers Regional Hospital","Fredericton","New Brunswick",{"type":56,"coordinates":122},[123,124],-66.66558,45.94541,{"lat":124,"lon":123},{"facility":127,"status":50,"city":128,"state":120,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":129,"geoPoint":133,"contacts":26},"The Moncton Hospital, Horizon Health Network","Moncton",{"type":56,"coordinates":130},[131,132],-64.7965,46.09454,{"lat":132,"lon":131},{"facility":135,"status":71,"city":136,"state":137,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":138,"geoPoint":142,"contacts":26},"Memorial University, Eastern Health","St. John's","Newfoundland and Labrador",{"type":56,"coordinates":139},[140,141],-52.70931,47.56494,{"lat":141,"lon":140},{"facility":144,"status":50,"city":145,"state":146,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":147,"geoPoint":151,"contacts":26},"Dalhousie University; Izaak Walton Killam Health","Halifax","Nova Scotia",{"type":56,"coordinates":148},[149,150],-63.57688,44.64269,{"lat":150,"lon":149},{"facility":5,"status":50,"city":153,"state":154,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":155,"geoPoint":159,"contacts":26},"Hamilton","Ontario",{"type":56,"coordinates":156},[157,158],-79.84963,43.25011,{"lat":158,"lon":157},{"facility":161,"status":50,"city":162,"state":154,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":163,"geoPoint":167,"contacts":26},"Queen's University, Kingston General Hospital Health Sciences Centre","Kingston",{"type":56,"coordinates":164},[165,166],-76.48098,44.22976,{"lat":166,"lon":165},{"facility":169,"status":50,"city":170,"state":154,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":171,"geoPoint":175,"contacts":26},"Western University; London Health Sciences Centre, Victoria Hospital","London",{"type":56,"coordinates":172},[173,174],-81.23304,42.98339,{"lat":174,"lon":173},{"facility":177,"status":50,"city":178,"state":154,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":179,"geoPoint":183,"contacts":26},"University of Ottawa; The Ottawa Hospital","Ottawa",{"type":56,"coordinates":180},[181,182],-75.69812,45.41117,{"lat":182,"lon":181},{"facility":185,"status":50,"city":186,"state":154,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":187,"geoPoint":191,"contacts":26},"Mount Sinai Hospital","Toronto",{"type":56,"coordinates":188},[189,190],-79.39864,43.70643,{"lat":190,"lon":189},{"facility":193,"status":50,"city":186,"state":154,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":194,"geoPoint":196,"contacts":26},"Sunnybrook Health Sciences Center",{"type":56,"coordinates":195},[189,190],{"lat":190,"lon":189},{"facility":198,"status":50,"city":199,"state":200,"zip":201,"country":53,"countryCode":54,"cosmosGeoPoint":202,"geoPoint":206,"contacts":26},"Hopital Maisonneuve Rosemont, CIUSSS de l'est de l'Ile de Montréal","Montreal","Quebec","H1T 2M4",{"type":56,"coordinates":203},[204,205],-73.58781,45.50884,{"lat":205,"lon":204},{"facility":208,"status":50,"city":199,"state":200,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":209,"geoPoint":211,"contacts":26},"McGill University, McGill University Health Center, Royal Victoria Hospital",{"type":56,"coordinates":210},[204,205],{"lat":205,"lon":204},{"facility":213,"status":71,"city":199,"state":200,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":214,"geoPoint":216,"contacts":26},"Sir Mortimer B. Davis Jewish General Hospital; McGill University",{"type":56,"coordinates":215},[204,205],{"lat":205,"lon":204},{"facility":218,"status":50,"city":199,"state":200,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":219,"geoPoint":221,"contacts":26},"The Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal",{"type":56,"coordinates":220},[204,205],{"lat":205,"lon":204},{"facility":223,"status":50,"city":224,"state":200,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":225,"geoPoint":229,"contacts":26},"Université Laval, Centre de recherche du CHU de Québec","Québec",{"type":56,"coordinates":226},[227,228],-71.21454,46.81228,{"lat":228,"lon":227},{"facility":231,"status":50,"city":232,"state":200,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":233,"geoPoint":237,"contacts":26},"(CIUSSS de l'Estrie-CHUS); Université de Sherbrooke","Sherbrooke",{"type":56,"coordinates":234},[235,236],-71.89908,45.40008,{"lat":236,"lon":235},{"facility":239,"status":71,"city":240,"state":241,"zip":26,"country":53,"countryCode":54,"cosmosGeoPoint":242,"geoPoint":246,"contacts":26},"University of Saskatchewan, Regina General Hospital","Saskatoon","Saskatchewan",{"type":56,"coordinates":243},[244,245],-106.66892,52.13238,{"lat":245,"lon":244},{"type":248,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[250,252,254,257,259,261],{"name":251,"class":6},"Hamilton Health Sciences Corporation",{"name":253,"class":6},"Sunnybrook Research Institute",{"name":255,"class":256},"Women's and Children's Hospital, Australia","OTHER_GOV",{"name":258,"class":256},"Canadian Institutes of Health Research (CIHR)",{"name":260,"class":6},"Medical Research Future Fund",{"name":262,"class":6},"University of Adelaide","100448026","phase-4-single-dose-of-antenatal-corticosteroids-for-pregnancies-at-risk-of-preterm-delivery-snacs-100448026",false,"NCT05114096","Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)","Single Dose of Antenatal Corticosteroids (SNACS) Randomized Controlled Trial for Pregnancies at Risk of Preterm Delivery: To Keep Babies and Children Safe","SNACS","Inclusion Criteria:\n\n1. Pregnant people, aged 18 to 55 years old, at risk of preterm birth with a singleton or twins between 22 weeks and 0 days and \\\u003C34 weeks and 6 days gestation who have received only a single dose of Celestone within 24 hours\n2. Capable of giving informed, written consent.\n\nExclusion Criteria:\n\n1. Contraindication to corticosteroids\n2. Systemic corticosteroids for medical conditions during the pregnancy (e.g. lupus, severe asthma, Covid, etc).\n3. Previous participation in this trial (in a previous pregnancy)\n4. Known severe\u002Flife-threatening fetal or pregnant patient condition (e.g. fetal congenital\u002Fchromosomal abnormality)\n5. Demise of one or more fetuses after 14 weeks and 0 days","FEMALE","18 Years","55 Years",{"count":275,"type":276},3254,"ESTIMATED","INTERVENTIONAL",[279],"PHASE4","Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome.\n\nThe standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity.\n\nThe investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.",[282,283,284,285,286],"Preterm Birth","Premature Birth","Complication of Prematurity","Obstetric Labor, Premature","Pregnancy Complications",[288,289,290,291,292,293,294,295,296,297,298,299,300,301,302],"Premature birth","Preterm birth","Obstetric labour","Betamethasone","Betamethasone Valerate","Betamethasone-17,21-dipropionate","Betamethasone benzoate","Betamethasone sodium phosphate","Anti-Inflammatory Agents","Glucocorticoids","Hormones","Hormones, Hormone Substitutes and Hormone Antagonists","Physiological Effect of Drugs","Anti-Asthmatic Agents","Respiratory System Agents","2026-01-05",{"date":305,"type":306},"2026-01-07","ACTUAL",{"date":308,"type":306},"2023-07-20",{"date":310,"type":276},"2029-12-31",{"name":5,"class":6},25]