[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602525":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":37,"locations":47,"responsibleParty":63,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":25,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":90,"overallStatus":49,"whyStopped":25,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Saint Petersburg State University, Russia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hydrocortisone group","EXPERIMENTAL","Participants receive endotracheal tubes coated with 1% hydrocortisone ointment to reduce postoperative sore throat and hoarseness.",[13],"Drug: Hydrocortisone Acetate 1% Ointment",{"label":15,"type":10,"description":16,"interventionNames":17},"Lidocaine group","Participants receive endotracheal tubes coated with 0.05% lidocaine and chlorhexidine solution (Cathelgel).",[18],"Drug: Lidocaine hydrochloride 0,05% with chlorhexidine",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Hydrocortisone Acetate 1% Ointment","Endotracheal tubes will be coated with 1% hydrocortisone acetate ointment prior to intubation. The ointment will be applied uniformly to the outer surface of the tube. This intervention aims to reduce postoperative throat inflammation and pain.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Lidocaine hydrochloride 0,05% with chlorhexidine","Endotracheal tubes will be treated with 0.05% lidocaine hydrochloride solution combined with chlorhexidine (Cathejell). The solution will be applied to the tube surface before intubation to provide local anesthesia and reduce postoperative throat discomfort.",[15],[31],"Cathejell",[33],{"name":34,"affiliation":35,"role":36},"Sergey M. Efremov, MD, PhD","Saint Petersburg State University Hospital","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":25,"email":42},"Sergey M. Efremov, D. Med. Sc.","CONTACT","+79137946090","efremovsergm@gmail.com",{"name":44,"role":40,"phone":45,"phoneExt":25,"email":46},"Alexey Y. Kulikov, Ph. D. (Med.)","+79217896909","alexeykulikov1987@yandex.ru",[48],{"facility":35,"status":49,"city":50,"state":25,"zip":25,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Saint Petersburg","Russia","RU",{"type":54,"coordinates":55},"Point",[56,57],30.31413,59.93863,{"lat":57,"lon":56},[60],{"name":61,"role":40,"phone":62,"phoneExt":25,"email":42},"Sergey Efremov","79137946090",{"type":36,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Efremov Sergey","Deputy director for science, Saint-Petersburg state university hospital",[67],{"name":68,"class":69},"Smooth Drug Development","UNKNOWN","100602525","phase-4-sore-throat-after-open-neck-elective-surgery-100602525",false,"NCT07124650","Sore Throat After Open Neck Elective Surgery","Effect of Hydrocortisone and Lidocaine on Endotracheal Tube for Sore Throat and Hoarseness After Thyroid\u002FParathyroid Surgery With Neuromonitoring: A Randomized Controlled Trial","STONES","Inclusion Criteria:\n\n* Patients scheduled for elective open surgery on the thyroid\u002Fparathyroid glands with intraoperative neuromonitoring.\n* Age ≥18 years.\n* Willing and able to provide voluntary informed consent for participation in the study.\n\nExclusion Criteria:\n\n* Pregnancy (for women of childbearing potential).\n* Known allergy to hydrocortisone or lidocaine.\n* Refusal to participate in the study.","ALL","18 Years",{"count":81,"type":82},764,"ESTIMATED","INTERVENTIONAL",[85],"PHASE4","This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough following thyroid or parathyroid surgery with neuromonitoring.\n\nA total of 764 adult patients undergoing elective neck surgery at Saint-Petersburg State University Hospital will be enrolled and randomly assigned to receive either a hydrocortisone-coated or lidocaine-coated endotracheal tube.\n\nOutcomes will be assessed upon awakening from anesthesia, at 24 hours, and again at 3 days postoperatively.\n\nThe findings may contribute to improving postoperative comfort and recovery for patients undergoing similar surgical procedures.",[88,89],"Postoperative Sore Throat, Cough, Hoarseness","Thyroid and Parathyroid Surgery",[91,92,93,94,95],"Hydrocortisone","Lidocaine","Endotracheal tube","Neuromonitoring","Randomized controlled trial","2026-04-06",{"date":98,"type":99},"2026-04-13","ACTUAL",{"date":101,"type":99},"2025-09-15",{"date":103,"type":82},"2027-05",{"name":5,"class":6},1]