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Daptomycin 8-10mg\u002Fkg per day intravenously. The choice of vancomycin or daptomycin will be at the clinician's discretion. Dosing will be based on renal function.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Methicillin-resistant staphylococcus aureus (MRSA) - Standard + B-Lactam Arm (backbone therapy)","EXPERIMENTAL","Vancomycin or Daptomycin (Standard Therapy) + Beta-Lactam (β-lactam) Arm\n\nIn addition to standard treatment an intravenous β-lactam will be added for the first 7 calendar days following randomisation (day 1 being the day of randomisation - hence patients will receive 6-7 days of β-lactam). This β-lactam will be intravenous cefazolin 2g every 8 hours. For patients with renal impairment the intravenous cefazolin administration doses will be adjusted.",[18,19],"Drug: Cefazolin","Drug: Vancomycin",{"label":21,"type":10,"description":22,"interventionNames":12},"Methicillin-susceptible staphylococcus aureus (MSSA) - Standard Therapy Arm (backbone therapy)","Flucloxacillin or cloxacillin - Standard Therapy Arm\n\nEither intravenous flucloxacillin\u002Fcloxacillin 2g every 4 or 6 hours. The minimum protocol duration of allocated study treatment is 14 days for those not allocated to early oral switch, and 5 days for those allocated to early oral switch. For patients with renal impairment or critical illness the intravenous flucloxacillin administration dose will be adjusted.",{"label":24,"type":15,"description":25,"interventionNames":26},"Methicillin-susceptible staphylococcus aureus (MSSA) - Interventional Arm (backbone therapy)","Cefazolin - Interventional Arm\n\nIntravenous cefazolin 2g every 6 or 8 hours. The minimum protocol duration of allocated study treatment is 14 days for those not allocated to early oral switch, and 5 days for those allocated to early oral switch. For patients with renal impairment or critical illness the intravenous cefazolin administration dose will be adjusted.",[18],{"label":28,"type":10,"description":22,"interventionNames":12},"Penicillin-susceptible staphylococcus aureus (PSSA) - Standard Therapy Arm (backbone therapy)",{"label":30,"type":15,"description":31,"interventionNames":32},"Penicillin-susceptible staphylococcus aureus (PSSA) - Interventional Arm (backbone therapy)","Benzylpenicillin - Interventional Arm\n\nIntravenous benzylpenicillin 1.8g (3 million units) every 4 or 6 hours. The minimum protocol duration of allocated study treatment is 14 days for those not allocated to early oral switch, and 5 days for those allocated to early oral switch. For patients with critical illness the intravenous benzylpenicillin administration doses will be adjusted.",[33],"Drug: Penicillin",{"label":35,"type":10,"description":36,"interventionNames":12},"No adjunctive treatment in combination with MRSA or MSSA or PSSA backbone therapy arm","No adjunctive therapy + backbone therapy arm for MRSA or MSSA or PSSA\n\nParticipants with either MRSA or MSSA or PSSA will have no adjunctive therapy in combination with their backbone therapy arm.",{"label":38,"type":15,"description":39,"interventionNames":40},"Adjunctive treatment in combination with MRSA or MSSA or PSSA backbone therapy arm","Adjunctive therapy + backbone therapy arm for MRSA or MSSA or PSSA Intravenous clindamycin (or lincomycin) 600mg every 8 hours from platform day 1 to day 5. No dosage adjustment is needed to renal impairment.",[41],"Drug: Clindamycin",{"label":43,"type":10,"description":44,"interventionNames":12},"Continue intravenous antibiotic therapies (backbone +\u002F- adjunctive therapy) - standard of care arm","Backbone therapy arm for MRSA or MSSA or PSSA +\u002F- adjunctive therapy will continue on intravenous antibiotic treatment for the length of time as per usual standard of care.\n\nParticipants eligibility is assessed at Day 7 (+\u002F- 2 days) if eligible will be randomised if not eligible then eligibility will be assess again at Day 14(+\u002F- 2 days). If eligibility is not met at day 14 then participant is excluded from this domain.",{"label":46,"type":15,"description":47,"interventionNames":48},"Switch to oral antibiotics at trial day 7 (+\u002F- 2 days) or Day 14 (+\u002F- 2 days) if eligible.","Switch from intravenous backbone antibiotic for MRSA or MSSA or PSSA to oral antibiotics at the treating clinicians discretion on trial Day 7 (+\u002F- 2 days) or trial Day 14 (+\u002F- 2 days).\n\nParticipants eligibility is assessed at Day 7 (+\u002F- 2 days). If eligible will be randomised, if not eligible then eligibility will be assessed again at Day 14 (+\u002F- 2 days). If eligibility is not met at day 14 then participant is excluded from this domain.",[49],"Other: Effectiveness of early switch to oral antibiotics",{"label":51,"type":10,"description":52,"interventionNames":12},"No PET\u002FCT scan - standard of care arm","Participants will not receive a PET\u002FCT scan, in addition to their allocated treatment interventions.\n\nParticipants eligibility is assessed at Day 7 (+\u002F- 2 days) if eligible will be randomised. If eligibility is not met then participant is excluded from this domain.",{"label":54,"type":15,"description":55,"interventionNames":56},"PET\u002FCT scan at trial day 7 (+\u002F- 2 days) if eligible","Participant will receive a PET\u002FCT scan at Day 5-12, in addition to their allocated treatment interventions.\n\nParticipants eligibility is assessed at Day 7 (+\u002F- 2 days) if eligible will be randomised. If eligibility is not met then participant is excluded from this domain.",[57],"Radiation: Whole body FDG PET\u002FCT Imaging",[59,63,70,75,81,85],{"type":60,"name":61,"description":61,"armGroupLabels":62,"otherNames":12},"DRUG","Cefazolin",[14,24],{"type":60,"name":64,"description":65,"armGroupLabels":66,"otherNames":67},"Penicillin","benzylpenicillin",[30],[68,69],"Benzylpenicillin","Penicillin G",{"type":60,"name":71,"description":71,"armGroupLabels":72,"otherNames":73},"Clindamycin",[38],[74],"Lincomycin",{"type":60,"name":76,"description":77,"armGroupLabels":78,"otherNames":79},"Vancomycin","Vancomycin or Daptomycin",[14],[80],"Daptomycin",{"type":6,"name":82,"description":83,"armGroupLabels":84,"otherNames":12},"Effectiveness of early switch to oral antibiotics","This involves testing a strategy rather than individual antibiotic agents",[46],{"type":86,"name":87,"description":88,"armGroupLabels":89,"otherNames":12},"RADIATION","Whole body FDG PET\u002FCT Imaging","Whole body FDG 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Marks",{"facility":1746,"status":111,"city":925,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1747,"geoPoint":1749,"contacts":1750},"Whittington Health",{"type":118,"coordinates":1748},[1691,1692],{"lat":1692,"lon":1691},[1751],{"name":1752,"role":143,"phone":12,"phoneExt":12,"email":12},"Ana Garcia Mingo",{"facility":1754,"status":111,"city":1755,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1756,"geoPoint":1760,"contacts":1761},"Manchester University Hospitals","Manchester",{"type":118,"coordinates":1757},[1758,1759],-2.23743,53.48095,{"lat":1759,"lon":1758},[1762],{"name":1763,"role":143,"phone":12,"phoneExt":12,"email":12},"Mike Riste",{"facility":1765,"status":111,"city":1766,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1767,"geoPoint":1771,"contacts":1772},"Newcastle Upon Tyne Hospitals","Newcastle upon Tyne",{"type":118,"coordinates":1768},[1769,1770],-1.61396,54.97328,{"lat":1770,"lon":1769},[1773],{"name":1774,"role":143,"phone":12,"phoneExt":12,"email":12},"Ashley (David) Price",{"facility":1776,"status":210,"city":1777,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1778,"geoPoint":1782,"contacts":1783},"Nottingham University Hospitals","Nottingham",{"type":118,"coordinates":1779},[1780,1781],-1.15047,52.9536,{"lat":1781,"lon":1780},[1784],{"name":1785,"role":143,"phone":12,"phoneExt":12,"email":12},"Tim Sloan",{"facility":1787,"status":111,"city":1788,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1789,"geoPoint":1793,"contacts":1794},"Oxford University Hospitals","Oxford",{"type":118,"coordinates":1790},[1791,1792],-1.25596,51.75222,{"lat":1792,"lon":1791},[1795],{"name":1796,"role":143,"phone":12,"phoneExt":12,"email":12},"Matthew Scarborough",{"facility":1798,"status":210,"city":1799,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1800,"geoPoint":1804,"contacts":1805},"Sheffield Teaching Hospitals","Sheffield",{"type":118,"coordinates":1801},[1802,1803],-1.4659,53.38297,{"lat":1803,"lon":1802},[1806],{"name":1807,"role":143,"phone":12,"phoneExt":12,"email":12},"Julia Grieg",{"facility":1809,"status":111,"city":1810,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":12,"geoPoint":12,"contacts":1811},"South Tees Hospitals","South Tees",[1812],{"name":1813,"role":143,"phone":12,"phoneExt":12,"email":12},"John Widdrington",{"facility":1815,"status":111,"city":1816,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1817,"geoPoint":1821,"contacts":1822},"University Hospital Southampton","Southampton",{"type":118,"coordinates":1818},[1819,1820],-1.40428,50.90395,{"lat":1820,"lon":1819},[1823],{"name":1824,"role":143,"phone":12,"phoneExt":12,"email":12},"Kordo Saeed",{"facility":1826,"status":210,"city":1827,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1828,"geoPoint":1832,"contacts":1833},"NHS Forth Valley","Stirling",{"type":118,"coordinates":1829},[1830,1831],-3.93682,56.11903,{"lat":1831,"lon":1830},[1834],{"name":1835,"role":143,"phone":12,"phoneExt":12,"email":12},"Elan Tsarfati",{"facility":1837,"status":210,"city":1838,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1839,"geoPoint":1843,"contacts":1844},"University Hospitals of North Midlands","Stoke",{"type":118,"coordinates":1840},[1841,1842],-2.86667,53.25,{"lat":1842,"lon":1841},[1845],{"name":1846,"role":143,"phone":12,"phoneExt":12,"email":12},"Krishna Banavathi",{"facility":1848,"status":111,"city":1849,"state":12,"zip":12,"country":1529,"countryCode":1530,"cosmosGeoPoint":1850,"geoPoint":1854,"contacts":1855},"Swansea Bay University Health Board","Swansea",{"type":118,"coordinates":1851},[1852,1853],-3.94323,51.62079,{"lat":1853,"lon":1852},[1856],{"name":1857,"role":143,"phone":12,"phoneExt":12,"email":12},"Brendan Healy",{"type":1859,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[1861,1863,1865,1867,1869,1871,1872,1873,1875,1877,1879,1881,1882,1884,1885,1887],{"name":1862,"class":6},"Berry Consultants",{"name":1864,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",{"name":1866,"class":6},"Menzies School of Health Research",{"name":1868,"class":6},"Aotearoa Clinical Trials",{"name":1870,"class":6},"Queensland University of Technology",{"name":994,"class":6},{"name":1474,"class":6},{"name":1874,"class":6},"Telethon Kids Institute",{"name":1876,"class":6},"The Peter Doherty Institute for Infection and Immunity",{"name":1878,"class":6},"The University of Queensland",{"name":1880,"class":6},"UMC Utrecht",{"name":1286,"class":6},{"name":1883,"class":6},"King's College London",{"name":1163,"class":6},{"name":1886,"class":6},"University College, London",{"name":1888,"class":6},"The Methodist Hospital Research Institute","100449794","phase-4-staphylococcus-aureus-network-adaptive-platform-trial-100449794",false,"NCT05137119","Staphylococcus Aureus Network Adaptive Platform Trial","SNAP","PLATFORM Inclusion Criteria:\n\nPatients must fulfil all of the following criteria to be eligible to enter the SNAP trial:\n\n1. Staphylococcus aureus complex grown from ≥1 blood culture\n2. Admitted to a participating hospital at the time of eligibility assessment (OR if patient has died, they were admitted to this site anytime from the time of blood culture collection until the time of eligibility assessment)\n\nPLATFORM Exclusion Criteria:\n\nPotentially eligible participants meeting any of the following criteria at the time of eligibility assessment for platform entry will be excluded from the randomised platform (but may still participate in the registry):\n\n1. Time of anticipated platform entry is greater than 72 hours post collection of the index blood culture (Where the time of culture collection is not recorded, the time of laboratory registration of the sample will be used as an alternative)\n2. Polymicrobial bacteraemia, defined as more than one organism (at species level) in the index blood cultures OR in any subsequent blood culture reported between the collection of the index blood culture and platform eligibility assessment, excluding those organisms judged to be contaminants by either the microbiology laboratory or treating clinician.\n3. Known previous participation in the randomised SNAP platform\n4. Known positive blood culture for S. aureus (of the same silo: PSSA, MSSA or MRSA) between 72 hours and 180 days prior to the time of eligibility assessment\n5. Treating team deems enrolment in the study is not in the best interest of the patient\n6. Treating team believes that death is imminent and inevitable\n7. Patient is for end-of-life care and antibiotic treatment is considered not appropriate\n8. Patient \\\u003C18 years of age and paediatric recruitment not approved at recruiting site\n9. Patient has died since the collection of the index blood culture\n\nTo be included in any of the following DOMAINS the participant must met eligible for the PLATFORM (as listed above)\n\nADJUNCTIVE TREATMENT DOMAIN\n\nInclusion Criteria:\n\n1. All participants that met the PLATFORM eligible are eligible to be included in this domain unless they meet any of the following exclusions listed.\n2. Patients are eligible for this domain regardless of S. aureus susceptibility testing results to clindamycin.\n\nExclusion criteria:\n\n1\\. Previous type 1 hypersensitivity reaction to lincosamides 2. Currently receiving clindamycin (lincomycin) or linezolid which cannot be ceased or substituted 3. Necrotising fasciitis 4. Current C. difficile associated diarrhoea (any severity) 5. Current severe diarrhoea from any cause (defined as Grade 3 or higher) 5. Known CDAD (C.Difficile Associated Diarrhoea) in the past 3 months, or CDAD relapse in the past 12 months 6. At the time of domain eligibility assessment, more than 4 hours has elapsed since platform entry 7. Treating clinician deems enrolment in this domain is not in the best interest of the patient\n\nPSSA, MSSA TREATMENT DOMAIN (backbone)\n\nInclusion Criteria:\n\n1. For PSSA silo: Index blood culture isolate is penicillin-susceptible as per the Microbiology Appendix. In short, this will require phenotypic disc testing with EUCAST (a P1 disc diffusion with zone \\>=26mm OR a P1 disc diffusion with zone \\>=26mm and the zone edge is NOT sharp) OR CLSI (a P10 disc diffusion) defined criteria.\n2. For MSSA silo: Index blood culture isolate is methicillin-susceptible as per the Microbiology Appendix.\n\nNote that where trial sites are not testing for penicillin-susceptibility, patients with MSSA\u002FPRSA can be included in the MSSA silo, but those with MSSA\u002FPSSA (but not confirmed with a P-disc) will be excluded from the backbone domain. The rationale for this is that patients with MSSA but not tested with a P-disc may be truly PSSA (with no blaZ). If the cefazolin inoculum effect (CIE) is a clinically relevant entity, then including patients with an organism without blaZ (and hence cannot have a CIE phenotype), will bias towards non-inferiority of cefazolin compared to (flu)cloxacillin.\n\nFor PSSA, the requirement for laboratories to use an accredited phenotypic test for a penicillin-susceptible phenotype, is to ensure clinical safety according to internationally accepted guidelines. The automated antimicrobial susceptibility testing, and other phenotypic tests, have poor sensitivity for detection of blaZ compared to a gold standard of blaZ PCR. Therefore, patients could be placed at risk of treatment with benzylpenicillin when the infecting isolate is actually blaZ positive, unless these guidelines are followed.\n\nExclusion Criteria (PSSA \\& MSSA):\n\n1. \\>72 hours have elapsed since the collection of the index blood culture (i.e. the time of collection of the first positive blood culture from the patient during this episode)\n2. History of type I hypersensitivity reaction (i.e. anaphylaxis or angioedema) to any penicillin or cephalosporin\n3. History of severe delayed reaction (e.g. allergic interstitial nephritis, cutaneous vasculitis, Stevens-Johnson, DRESS, etc.) to any penicillin or cephalosporin\n4. PSSA silo: Non-severe rash to any penicillin (unless patient has been subsequently de-labelled; this criteria does not include criteria 2 and 3 above), or MSSA silo: Non-severe rash to cefazolin or any penicillin (unless patient has been subsequently de-labelled); (Nausea, diarrhoea, headache, and other non-specific symptoms are NOT allergies, they are drug intolerance, and they are not exclusion criteria. Similarly, a vague history of an allergy of unclear nature, or a family history of allergy are not exclusions.)\n5. Treating team deems enrolment in this domain is not in the best interest of the patient\n6. Currently receiving maintenance dialysis (haemodialysis or peritoneal dialysis); (Acute renal replacement therapy (including CRRT, haemodialysis or peritoneal dialysis) are not exclusions. Such patients are eligible as long as appropriate vascular access is available or can be arranged.)\n7. Polymicrobial bacteraemia (defined as more than one organism \\[at species level\\] in blood cultures, excluding those organisms judged to be contaminants by either the microbiology laboratory or treating clinician) reported between collection of the index blood culture and backbone domain eligibility assessment\n8. Patient currently being treated with a systemic antibacterial agent that cannot be ceased or substituted for interventions allocated within the platform (unless antibiotic is listed in Table 1 of the DSA, which specifies allowed antibiotics with limited absorption from the gastrointestinal tract or negligible antimicrobial activity against S. aureus)\n\nMRSA TREATMENT DOMAIN (backbone)\n\nInclusion Criteria:\n\n1\\. MRSA confirmed microbiologically\n\nExclusion Criteria:\n\n1. Time to allocation reveal is \\>72 hours from time of index blood culture collection\n2. Severe allergy to any beta-lactam (including cefazolin) Immediate severe allergy: Anaphylaxis\u002Fangioedema Severe delayed allergy: Severe cutaneous adverse reaction (SCAR; including Steven Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) and acute generalised exanthematous pustulosis (AGEP)), severe drug induced liver injury, proven allergic interstitial nephritis, immune-mediated haemolytic anaemia and other severe cytopenia.\n3. Non-severe rash to cefazolin Nausea, diarrhoea, headache and other non-specific symptoms are NOT allergies, they are drug intolerance, and they are not exclusion criteria. Similarly, a vague history of an allergy of unclear nature, or a family history of allergy are not exclusions.)\n\n3\\. Severe allergy or non-severe rash to both vancomycin AND daptomycin Vancomycin infusion reaction (formerly known as \"red man syndrome\") is due to direct histamine release and is not generally an allergy, and therefore is not considered an exclusion.\n\n5\\. Treating team deems enrolment in the domain is not in the best interest of the patient 6. Polymicrobial bacteraemia (defined as more than one organism \\[at species level\\] in blood cultures, excluding those organisms judged to be contaminants by either the microbiology laboratory or treating clinician) reported between collection of the index blood culture and backbone domain eligibility assessment.\n\n7\\. Patient currently being treated with a systemic antibacterial agent that cannot be ceased or substituted for interventions allocated within the platform (unless antibiotic is listed in Table 1 of the DSA, which specifies allowed antibiotics with limited absorption from the gastrointestinal tract or negligible antimicrobial activity against S. aureus)\n\nEARLY ORAL SWITCH DOMAIN\n\nInclusion Criteria:\n\nDay 7 (+\u002F- 2 days):\n\n1. Clearance of SAB by platform Day 2: blood cultures negative for S. aureus from platform Day 2 onwards AND no known subsequent positive blood cultures\n2. Afebrile (\\\u003C37.8°C) for the past 72 hours (at time of judging eligibility)\n3. Primary focus is either line related (either central or peripheral IV cannula) or skin and soft tissue, AND source control achieved (for 'line-related' this means line removed; for 'skin and soft tissue' means site PI considers source control to have been achieved and any abscess more than 2cm diameter has been drained)\n4. No evidence of metastatic foci (on clinical or radiological examination, but radiological imaging is not required to exclude metastatic foci if not clinically indicated)\n\nDay 14 (+\u002F- 2 days):\n\n1. Clearance of SAB by platform Day 5: blood cultures negative for S. aureus from platform Day 5 (+\u002F-1 day) AND no known subsequent positive blood cultures. If the most recent blood culture from Day 2-4 is negative for S. aureus, blood cultures do not need to be repeated on Day 5 to fulfil eligibility criteria (Day 5 blood cultures will be assumed to be negative in this situation)\n2. Afebrile (\\\u003C37.8°C) for the past 72 hours (at time of judging eligibility)\n3. Site Principal Investigator has determined that source control is adequate\n\nExclusion Criteria:\n\nWhen judging eligibility at platform Day 7 (+\u002F- 2 days) and at Day 14 (+\u002F- 2 days), exclusion criteria are:\n\n1. Adherence to oral agents unlikely (as judged by site PI in consultation with the treating team)\n2. Unreliable gastrointestinal absorption (e.g. vomiting, diarrhoea, nil by mouth, anatomical reasons)\n3. There are no appropriate oral antibiotics due to contraindications, drug availability, or antibiotic resistance\n4. Ongoing IV therapy unsuitable e.g. no IV access\n5. Clinician deems not appropriate for early oral switch\n6. Patient no longer willing to participate in domain In the lead-up to judging eligibility, it may be helpful to discuss with the patient the potential for continued IV treatment versus oral switch, to allow hospital discharge planning\n7. Clinical team deems that sufficient duration of antibiotic therapy has already been provided\n\nExclusions when judging eligibility for early oral switch at trial Day 7 (+\u002F- 2 days):\n\n1. Presence of prosthetic cardiac valve, pacemaker or other intracardiac implant\n2. Presence of intravascular clot, graft, or other intravascular prosthetic material Intravascular clot excludes superficial peripheral IV line-related thrombophlebitis. Intravascular prosthetic material excludes coronary artery stents)\n3. Intravascular\u002Fintracardiac infections (e.g. endocarditis, mycotic aneurysm)\n4. Presence of other intracardiac abnormalities felt to put patient at increased risk of endocarditis (e.g., bicuspid aortic valve)\n\nPET\u002FCT DOMAIN\n\nInclusion Criteria:\n\n1. PET\u002FCT participating site\n2. Patient is accessible for PET\u002FCT - a patient is considered accessible if the site team are able to access the participant medical records, arrange for a PET\u002FCT scan for the patient, and discuss this domain with the patient and their treating healthcare providers.\n\nExclusion Criteria:\n\n1. Pregnant - patients of childbearing potential should be assessed for pregnancy status and a pregnancy test performed (if not performed within the past 10 days)\n2. Currently breastfeeding\n3. \\\u003C 18 years of age\n4. Patient has had PET\u002FCT in the past 7 days\n5. Patient needs PET\u002FCT in the next 7 days (in the opinion of the clinical team, at the time of eligibility assessment)\n6. Clinically unstable for PET\u002FCT (as judged by the treating clinical team, taking into account need for organ support (including inotropes) and capacity to lie flat for the PET\u002FCT)\n7. Contraindication to PET\u002FCT (e.g., claustrophobia, persistently elevated blood sugar levels \\[\\>12.5mmol\u002FL\\] that cannot be corrected).\n8. Patient no longer willing to participate in the domain - in the days leading up to judging eligibility, it may be helpful to discuss with the patient the potential for PET\u002FCT vs no PET\u002FCT to allow imaging planning\n9. Clinician deems participation in this domain is not in the patient's best interests","ALL",{"count":1898,"type":1899},8000,"ESTIMATED","INTERVENTIONAL",[1902],"PHASE4","The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is an International Multi-Centered Randomised Adaptive Platform Clinical Trial to evaluate a range of interventions to reduce mortality for patients with Staphylococcus Aureus bacteraemia (SAB).",[1905],"Staphylococcus Aureus Bacteremia",[1907,1908,1909,1910,1911,1912],"Methicillin-resistant Staphylococcus aureus (MRSA)","Methicillin-susceptible Staphylococcus aureus (MSSA)","Penicillin-susceptible Staphylococcus aureus (PSSA)","Staphylococcus aureus","S. aureus","Staph Aureus Bacteremia (SAB)","2026-04-29",{"date":1915,"type":1916},"2026-05-06","ACTUAL",{"date":1918,"type":1916},"2022-02-16",{"date":1920,"type":1899},"2028-12-01",{"name":5,"class":6},161]