[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556312":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":37,"locations":43,"responsibleParty":63,"collaborators":29,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":29,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":90,"overallStatus":46,"whyStopped":29,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Third Military Medical University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Simvastatin combined with Amlodipine besylate","EXPERIMENTAL","after 1:1 randomization, 60 patients with primary aldosteronism were treated with Simvastatin combined with Amlodipine besylate for 6 months",[13],"Drug: Simvastatin combined with Amlodipine besylate",{"label":15,"type":10,"description":16,"interventionNames":17},"Simvastatin combined with Spironolactone and Amlodipine besylate.","after 1:1 randomization, 60 patients with primary aldosteronism were treated with Simvastatin combined with Spironolactone and Amlodipine besylate for 6 months",[18],"Drug: Simvastatin combined with Spironolactone and Amlodipine besylate.",{"label":20,"type":10,"description":21,"interventionNames":22},"Amlodipine besylate combined with Spironolactone","after 1:1 randomization, 60 patients with primary aldosteronism were treated with Amlodipine besylate combined with Spironolactone for 6 months",[23],"Drug: Amlodipine besylate combined Spironolactone",[25,30,33],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","6-month treatment of Simvastatin combined with Amlodipine besylate",[9],null,{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":29},"6-month treatment of Simvastatin combined with Spironolactone and Amlodipine besylate.",[15],{"type":26,"name":34,"description":35,"armGroupLabels":36,"otherNames":29},"Amlodipine besylate combined Spironolactone","6-month treatment of Amlodipine besylate combined with Spironolactone",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},"sun fang","CONTACT","+862368729587","sun_fang2007@163.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"No. 10 Changjiang River Branch, Yuzhong District，Chongqing, China","RECRUITING","Chongqing","Chongqing Municipality","400042","China","CN",{"type":53,"coordinates":54},"Point",[55,56],106.55771,29.56026,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":61,"phoneExt":29,"email":62},"Jingjing Wang","+86-02368757140","wii1017@163.com",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Zhiming Zhu","Department of Hypertension and Endocrinology","100556312","phase-4-statin-combined-with-amlodipine-treats-primary-aldosteronism-100556312",false,"NCT06523465","Statin Combined with Amlodipine Treats Primary Aldosteronism","A Prospective, Multi-center, Randomized Trial to Compare Statin Combined with CCB to MRA Combined with CCB in Primary Aldosteronism Treatment","STOP-PA","Inclusion Criteria:\n\n* Clinical diagnosis of primary aldosteronism\n\nExclusion Criteria:\n\n* Allergy to drugs in this study\n* Pregnancy\n* Severe liver and kidney dysfunction\n* Mental illness","ALL","18 Years","70 Years",{"count":79,"type":80},180,"ESTIMATED","INTERVENTIONAL",[83],"PHASE4","The drug treatment for primary aldosteronism (PA) is limited and difficult to improve long-term cardiovascular outcomes. This study plans to enroll patients with primary aldosteronism and randomly divide into 3 groups: scheme 1: Statin combined with amlodipine besylate, scheme 2: Statin combined with Spironolactone and Amlodipine besylate. scheme 3: Amlodipine besylate combined with Spironolactone , to observe the changes in plasma aldosterone level, 24-hour urinary aldosterone, blood pressure, and long-term cardiovascular risk.",[86,87,88,89],"Primary Aldosteronism","Statin","Mineralocorticoid Receptor Antagonist","Hypertension",[91,92,87],"primary aldosteronism","hypertension","2024-11-19",{"date":95,"type":96},"2024-11-22","ACTUAL",{"date":98,"type":96},"2024-09-10",{"date":100,"type":80},"2026-09-30",{"name":5,"class":6},1]