[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619219":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":42,"centralContacts":43,"locations":49,"responsibleParty":80,"collaborators":84,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":42,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":42,"overallStatus":52,"whyStopped":42,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"University Children's Hospital, Zurich","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Antihistamines plus oral steroids","ACTIVE_COMPARATOR","Participants receive oral antihistamines plus oral systemic corticosteroids for treatment of allergic reactions occurring during the oral food challenge. Intramuscular adrenaline may be administered as rescue medication if clinically indicated.",[13,14,15],"Drug: Antihistamines","Drug: Systemic corticosteroids","Drug: Adrenaline (rescue medication)",{"label":17,"type":10,"description":18,"interventionNames":19},"Antihistamines only (no steroids)","Participants receive oral antihistamines without systemic corticosteroids for treatment of allergic reactions occurring during the oral food challenge. Intramuscular adrenaline may be administered as rescue medication if clinically indicated.",[13,15],[21,29,36],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Antihistamines","Oral administration of antihistamines for treatment of allergic symptoms during the oral food challenge.",[17,9],[27,28],"Dimetindene maleate","Levocetirizine",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Systemic corticosteroids","Oral administration of systemic corticosteroids as adjunctive treatment of allergic reactions during the oral food challenge.",[9],[34,35],"Betamethasone","Prednisolone",{"type":22,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"Adrenaline (rescue medication)","Intramuscular administration of adrenaline as rescue treatment for severe allergic reactions (anaphylaxis), administered as clinically indicated.",[17,9],[41],"Adrenaline",null,[44],{"name":45,"role":46,"phone":47,"phoneExt":42,"email":48},"Johannes Trück, PD Dr. med. DPhil","CONTACT","+41 44 249 49 49","johannes.trueck@kispi.uzh.ch",[50,68],{"facility":51,"status":52,"city":53,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"University Children's Hospital Basel","RECRUITING","Basel","4031","Switzerland","CH",{"type":58,"coordinates":59},"Point",[60,61],7.57327,47.55839,{"lat":61,"lon":60},[64],{"name":65,"role":46,"phone":66,"phoneExt":42,"email":67},"Felicitas Bellutti Enders, Dr. med. PhD","+41 61 704 2770","felicitas.belluttienders@ukbb.ch",{"facility":69,"status":52,"city":70,"state":71,"zip":72,"country":55,"countryCode":56,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"University Children's Hospital, Zürich","Zurich","Canton of Zurich","8008",{"type":58,"coordinates":74},[75,76],8.55,47.36667,{"lat":76,"lon":75},[79],{"name":45,"role":46,"phone":47,"phoneExt":42,"email":48},{"type":81,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"SPONSOR_INVESTIGATOR","Johannes Trueck","Head, Division of Allergy",[85],{"name":51,"class":6},"100619219","phase-4-steroid-use-in-treatment-of-allergic-reactions-to-food-100619219",false,"NCT07341776","Steroid Use in Treatment of Allergic Reactions to Food","Evaluation of Emergency Medication in Children With Food Allergies: a Prospective, Randomized Clinical Multicenter Study Comparing Antihistamines Versus Antihistamines Plus Steroids in a Controlled Setting of Oral Food Challenges in Children.","SAFARI","Inclusion Criteria:\n\n* suspected or confirmed IgE-mediated food allergy\n\nExclusion Criteria:\n\n* Non-IgE mediated food allergies\n* Non-food allergies\n* Age outside the specified range\n* Contraindications for an oral food challenge or oral steroid use within one week before the challenge.","ALL","6 Months","18 Years",{"count":98,"type":99},160,"ESTIMATED","INTERVENTIONAL",[102],"PHASE4","In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary. When children have allergic reactions to foods, they are often given medications to relieve the symptoms. In addition to adrenaline and antihistamines, steroids are frequently administered in German-speaking Switzerland. However, it is unclear whether steroids are really helpful in this situation. To investigate this, the investigators are comparing two groups: one group receives additional steroids, and the other does not. Which treatment a participant receives is decided randomly, like flipping a coin. The study takes place during a pre-scheduled provocation test at the clinic. If an allergic reaction occurs, the usual emergency medications will be administered. Doctors will closely monitor how the reaction develops. No additional tests or visits are required. The results of this study could help improve allergy treatment in the future.",[105,106,107,108],"Anaphylactic Reaction","Anaphylaxis","Allergy in Children","IgE Mediated Food Allergy","2026-01-26",{"date":111,"type":112},"2026-01-27","ACTUAL",{"date":109,"type":112},{"date":115,"type":99},"2026-12",{"name":82,"class":6},2]