[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593492":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":63,"collaborators":25,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":25,"maxAge":25,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Chinese Academy of Medical Sciences, Fuwai Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Aspirin monotherapy","EXPERIMENTAL","Participants will receive Aspirin monotherapy (100 mg once daily, minimum 12 months).",[13],"Drug: Experimental: Aspirin monotherapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Aspirin + Clopicogrel","ACTIVE_COMPARATOR","Participants will receive Aspirin (100 mg once daily, minimum 12 months) plus clopidogrel (75 mg once daily for 3 months).",[19],"Drug: Active Comparator: Aspirin+Clopidogrel",[21,26],{"type":22,"name":23,"description":9,"armGroupLabels":24,"otherNames":25},"DRUG","Experimental: Aspirin monotherapy",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Active Comparator: Aspirin+Clopidogrel","Aspirin+Clopidogrel",[15],[31],{"name":32,"affiliation":5,"role":33},"Xiangbin Pan, MD,PhD","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+86(10)88396666","panxiangbin@fuwaihospital.org",{"name":40,"role":36,"phone":37,"phoneExt":25,"email":41},"Zizheng Liu, M.B","liuzizheng00@126.com",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Beijing","Beijing Municipality","100037","China","CN",{"type":51,"coordinates":52},"Point",[53,54],116.39723,39.9075,{"lat":54,"lon":53},[57,59,60,61],{"name":32,"role":36,"phone":58,"phoneExt":25,"email":38},"+861088396666",{"name":40,"role":36,"phone":37,"phoneExt":25,"email":41},{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"name":62,"role":33,"phone":25,"phoneExt":25,"email":25},"Shouzheng Wang, MD,PhD",{"type":33,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Pan Xiangbin","Principal Investigator","100593492","phase-4-strategies-for-antithrombotic-treatment-following-transcatheter-edge-to-edge-repair-in-patients-without-an-indication-for-oral-anticoagulant-100593492",false,"NCT07007143","STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant","STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-edge Repair in Patients Without an Indication for Oral Anticoagulant: a Multicenter Randomized Controlled Trial","STAR-TEER Ⅱ","Inclusion Criteria:\n\n* Successful TEER procedure, defined as technical success per MVARC criteria.\n* Ability and willingness to comply with the trial protocol.\n* Provision of written informed consent.\n* Women of childbearing potential must use effective contraception from the time of consent until the final dose of antithrombotic therapy.\n* Antithrombotic strategy approved by the investigator.\n\nExclusion Criteria:\n\n* Severe renal impairment (creatinine clearance \\\u003C 15 mL\u002Fmin or requiring dialysis).\n* Ongoing postoperative bleeding (defined as overt bleeding with a ≥3.0 g\u002FdL drop in hemoglobin or requiring ≥3 units of blood transfusion), or vascular complications following the index TEER procedure.\n* Platelet count \\\u003C 50 × 10\\^9 \u002FL.\n* Need for reoperation due to complications of the index TEER procedure.\n* Recent ( \\\u003C 12 month) intracranial or intracerebral hemorrhage.\n* Recent ( \\\u003C 12 month) gastrointestinal ulcers or hemorrhage.\n* Hepatic disease with coagulopathy.(eg, Child-Pugh class B or C cirrhosis).\n* Allergy, intolerance, or contraindication to research drugs.\n* Participation in another investigational drug or device study within 30 days.\n* Indication for long-term OAC.\n* Absolute indication for dual antiplatelet therapy; (eg, recent PCI).\n* Life expectancy \\\u003C 12 months.\n* Pregnancy or breastfeeding.","ALL",{"count":76,"type":77},1032,"ESTIMATED","INTERVENTIONAL",[80],"PHASE4","Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups). Transcatheter edge-to-edge repair (TEER) is now a well-established strategy in high-risk patients with MR. Globally, over 250,000 patients have benefited from the TEER technique. However, no dedicated study has prospectively evaluated different antithrombotic strategies following TEER in patients undergone TEER procedure. Current guidelines do not provide any recommendations for the antithrombotic management of TEER. Consequently, considerable treatment variation exists in clinical studies and practice. The investigators will conduct a multicenter, open-label randomized trial to compare different antithrombotic strategies following TEER in patients without an indication for OAC.",[83],"Mitral Regurgitation",[85,83,86,87,88,89,90,91,92,93,94,95,96,97],"Transcatheter Edge-to-Edge Repair (TEER)","Cardiovascular Diseases","Embolism and Thrombosis","Bleeding","Aspirin","Clopidogrel","Antithrombotic treatment","Platelet Aggregation Inhibitors","Antiplatelet Drug","Single Antiplatelet Therapy（SAPT）","Double Antiplatelet Therapy（DAPT）","Stroke","Myocardial Infarction","2026-03-05",{"date":100,"type":101},"2026-03-09","ACTUAL",{"date":103,"type":101},"2025-07-31",{"date":105,"type":77},"2029-09-30",{"name":5,"class":6},1]