[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636486":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":30,"centralContacts":34,"locations":29,"responsibleParty":39,"collaborators":29,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":29,"enrollmentInfo":52,"targetDuration":29,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":71,"whyStopped":29,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":29},{"fullName":5,"class":6},"Duke University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Lateral Quadratus Lumborum block","ACTIVE_COMPARATOR","Participants receive quadratus lumborum block under ultrasound guidance, with 30mL of 1.5% lidocaine on one visit.",[13],"Combination Product: Quadratus Lumborum with 1.5% Lidocaine",{"label":15,"type":16,"description":17,"interventionNames":18},"Anterior Quadratus Lumborum Block","EXPERIMENTAL","Participants receive anterior quadratus lumborum block under ultrasound guidance, with 30mL of 1.5% lidocaine on one visit.",[13],{"label":20,"type":16,"description":21,"interventionNames":22},"Posterior Quadratus Lumborum Block","Participants receive posterior quadratus lumborum block under ultrasound guidance, with 30mL of 1.5% lidocaine on one visit.",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"COMBINATION_PRODUCT","Quadratus Lumborum with 1.5% Lidocaine","For the anterior QL block, a curvilinear probe and nerve stimulator will be used. Local anesthetic will be deposited anterior to the QL muscle but posterior to the psoas muscle. A nerve stimulator at 2 Hz frequency, 1.5 mA will be used to aid in identification of intramuscular placement of the needle. Local anesthetic will only be deposited if no twitch is seen in either the QL or psoas muscle with an appropriate circuit formed. For the posterior QL block, a linear or curvilinear probe will be used, at the discretion of the anesthesiologist. Local anesthetic will be deposited posterior to the QL muscle such that anterior depression of the muscle is seen. For the lateral QL block, local anesthetic will be deposited lateral to the QL muscle.",[15,9,20],null,[31],{"name":32,"affiliation":5,"role":33},"Brian Mendelson, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":29,"email":38},"CONTACT","818-456-7040","brian.mendelson@duke.edu",{"type":40,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100636486","phase-4-study-of-ql-analgesic-response-and-extent-100636486",false,"NCT07566312","Study of QL Analgesic Response and Extent","Anterior Versus Posterior Versus Lateral Quadratus Lumborum Block: a Randomized Control Trial in Healthy Volunteers","SQUARE","Inclusion Criteria:\n\n* Ability to provide written informed consent\n* Ability and willingness to comply with the study procedures and duration requirements\n* ASA physical status 1 or 2\n* Age ≥ 18 years\n* Weight \\> 70kg\n\nExclusion Criteria:\n\n* BMI \\> 35kg.m2\n* Use of analgesics within 24 hours before the procedure\n* History of thoracic trauma or surgery\n* Abdominal deformities or abnormalities that may prevent proper block performance\n* Abdominal tattoos in the area of block performance\n* Systemic neuromuscular disease\n* Contraindications to regional anesthesia (e.g., infection, allergy, challenging sonoanatomy)\n* Structures are unable to be visualized by ultrasound\n* Pregnancy\n* Other known health conditions that would affect the participant's ability to successfully complete the study",true,"ALL","18 Years",{"count":53,"type":54},25,"ESTIMATED","INTERVENTIONAL",[57],"PHASE4","A total of 14-18 healthy volunteers will be included. There will be three different procedure days, separated by at least one week. On each visit, the subjects will receive a QL block, according to the randomization process. Each volunteer will undergo pre-procedure screening on the first visit. The blocks will be performed on the same side, by the same anesthesiologist, with at least one week between each block. An anterior QL block will be administered on one day, a posterior QL block on another, and a lateral QL block on the third. The order will be randomized, and both the subject and the research team member assessing the block will be blinded. To compare the dermatomal sensory block distribution, the investigators will use detailed mapping with pinprick, cold, and heat stimuli. A handheld dynamometric assessment of lower extremity strength. The testing will be performed 60 to 90 minutes after performance of the blocks.",[60,61,62],"Acute Pain","Postoperative Pain","Regional Anesthesia Block",[64,65,66,67,68,69,70],"Quadratus lumborum block","QL block","QL","Quadratus lumborum","Fascial plane block","Regional anesthesia","Abdominal blocks","NOT_YET_RECRUITING","2026-04-29",{"date":74,"type":75},"2026-05-05","ACTUAL",{"date":77,"type":54},"2026-05",{"date":79,"type":54},"2026-12",{"name":5,"class":6}]