[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100376551":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":46,"responsibleParty":69,"collaborators":44,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":44,"enrollmentInfo":81,"targetDuration":44,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":44,"overallStatus":48,"whyStopped":44,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Missouri-Columbia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo Group","PLACEBO_COMPARATOR","Patients in this group will be given the placebo (sterile saline).",[13],"Drug: saline 0.9%",{"label":15,"type":16,"description":17,"interventionNames":18},"Dexamethasone Group","ACTIVE_COMPARATOR","Patients in this group will be given the study drug (dexamethasone).",[19],"Drug: Dexamethasone",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dexamethasone","Patients included in the treatment group will have their surgical site lavaged with dexamethasone at the end of their surgery.",[15],[27],"Decadron",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"saline 0.9%","Patients included in the placebo group will have their surgical site lavaged with sterile saline at the end of their surgery.",[9],[33],"sterile saline",[35],{"name":36,"affiliation":37,"role":38},"Don Kim Moore, MD","Missouri Orthopaedic Institute","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Vickci Jones, MEd, CCRP","CONTACT","(573) 882-7583",null,"jonesvicki@health.missouri.edi",[47],{"facility":37,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Columbia","Missouri","65202","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-92.33407,38.95171,{"lat":58,"lon":57},[61,64,66],{"name":62,"role":42,"phone":63,"phoneExt":44,"email":45},"Vicki Jones, MEd,CCRP","573-882-7583",{"name":65,"role":38,"phone":44,"phoneExt":44,"email":44},"Don Moore, MD",{"name":67,"role":68,"phone":44,"phoneExt":44,"email":44},"Theodore Choma, MD","SUB_INVESTIGATOR",{"type":38,"investigatorFullName":65,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Assistant Professor, Orthopedic Surgery","100376551","phase-4-subjective-intraoperative-use-of-epidural-steroid-administration-following-discectomy-100376551",false,"NCT04182997","Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy","Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy for Herniated Lumbar Discs Is There a Role? - A Randomized Control Trial","Intra-Op","Inclusion Criteria:\n\n* Presenting to the University of Missouri hospital system - including the University of Missouri Hospital and Missouri Orthopaedic Institute - with a clinical assessment indicative of a lumbar disc herniation\n* Failed conservative treatment - rest, anti-inflammatory medications, physical therapy\n* Radiculopathy present - positive tension signs or sensory\u002Fmotor neurologic deficits present\n* Recent MRI confirming single-level lumbar disc herniation corresponding to clinical evaluation\n\nExclusion Criteria:\n\n* Concomitant spinal stenosis, segmental instability, or spondylolisthesis\n* Previous surgery at the affected level or recurrent herniation\n* Underlying disease that may affect response to steroids - immunocompromise, use of chronic steroids or immunosuppression\n* Pregnancy - qualitative human chorionic gonadotropin (hCG) testing will be performed prior to enrollment\n* Diagnosis of or symptoms concerning for cauda equina syndrome","ALL","18 Years",{"count":82,"type":83},200,"ESTIMATED","INTERVENTIONAL",[86],"PHASE4","The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.",[89],"Lumbar Disc Herniation","2026-05-31",{"date":92,"type":93},"2026-06-03","ACTUAL",{"date":95,"type":93},"2019-11-21",{"date":97,"type":83},"2026-12",{"name":5,"class":6},1]