[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623423":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":39,"responsibleParty":105,"collaborators":109,"id":117,"slug":118,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":119,"sex":125,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":18,"studyType":131,"phases":132,"briefSummary":134,"conditions":135,"keywords":18,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},{"fullName":5,"class":6},"Universiti Sains Malaysia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Honey group","ACTIVE_COMPARATOR","Subjects will be provided stingless bee honey packeted in sachets of 30g. They are required to consume 30gram of honey per day for a total of 90 days duration.",[13],"Biological: Stingless bee honey (Kelulut)",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-honey group","NO_INTERVENTION","Subjects in this group will not receive honey. Subjects will undergo comprehensive ophthalmic examination and blood taking for measurement of serum Interleukin-6 level before and after the duration of study.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BIOLOGICAL","Stingless bee honey (Kelulut)","Kelulut is stingless bee honey, a natural biologic product produced by stinglee bee species.",[9],[26],"Kelulut",[28],{"name":29,"affiliation":5,"role":30},"Azhany Yaakub, MD, MMed, PhD","STUDY_DIRECTOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"Thamarai Munirathinam, MD(Prague)","CONTACT","+60177712935","nitaraicz88@gmail.com",{"name":29,"role":34,"phone":18,"phoneExt":18,"email":38},"azhany@usm.my",[40,60,75,89],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Hospital Raja Perempuan Zainab II","RECRUITING","Kota Bharu","Kelantan","15586","Malaysia","MY",{"type":49,"coordinates":50},"Point",[51,52],102.24333,6.12361,{"lat":52,"lon":51},[55,59],{"name":56,"role":34,"phone":57,"phoneExt":18,"email":58},"Munira Yusoff, Masters of Ophthamology","+60139812116","drmyusoff@gmail.com",{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},{"facility":61,"status":42,"city":62,"state":44,"zip":63,"country":46,"countryCode":47,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Hospital Sultan Ismail Petra","Kuala Krai","18000",{"type":49,"coordinates":65},[66,67],102.19925,5.5313,{"lat":67,"lon":66},[70,74],{"name":71,"role":34,"phone":72,"phoneExt":18,"email":73},"Norihan Ibrahim, Masters of Ophthamology","+60196610635","norihanibrahim13@gmail.com",{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},{"facility":76,"status":42,"city":77,"state":44,"zip":78,"country":46,"countryCode":47,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Hospital Universiti Sains Malaysia","Kubang Kerian","16150",{"type":49,"coordinates":80},[81,82],102.27938,6.09123,{"lat":82,"lon":81},[85,87],{"name":86,"role":34,"phone":35,"phoneExt":18,"email":36},"Thamarai Munirathinam, Doctor of Medicine",{"name":88,"role":34,"phone":18,"phoneExt":18,"email":38},"Azhany Yaakub, MD (USM), MMed (Ophthal), PhD",{"facility":90,"status":42,"city":91,"state":92,"zip":93,"country":46,"countryCode":47,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Hospital Sultanah Nur Zahirah","Kuala Terengganu","Terengganu","20400",{"type":49,"coordinates":95},[96,97],103.1408,5.3302,{"lat":97,"lon":96},[100,104],{"name":101,"role":34,"phone":102,"phoneExt":18,"email":103},"Anita Che Omar, Masters of Ophthamology","+60139221105","drnoranita@moh.gov.my",{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},{"type":106,"investigatorFullName":107,"investigatorTitle":108,"investigatorAffiliation":76,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Thamarai Munirathinam","Doctor of Medicine (MD), Medical Officer, Prinicipal Investigator, Department of Ophthalmology,",[110,113,116],{"name":111,"class":112},"Hospital Raja Perempuan Zainab II, Kota Bahru, Kelantan","UNKNOWN",{"name":114,"class":115},"Hospital Sultanah Nur Zahirah, Kuala Terengganu","OTHER_GOV",{"name":76,"class":6},"100623423","phase-4-supplementary-kelulut-honey-therapy-in-juvenile-open-angle-glaucoma-effects-on-il-6-rnfl-and-dry-eye-100623423",false,"NCT07396441","Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye","Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye.","HONEY-JOAG","Inclusion Criteria:\n\nJOAG patients age 15 years old and above until 40 years old at the time of diagnosis Compliant to conventional treatment achieved target intraocular pressure\n\nExclusion Criteria:\n\nPatients with allergy to honey or honey-based products OCT signal less than 6\u002F10 Concurrent retinal diseases and other optic neuropathies Systemic neurodegenerative disease Systemic comorbidities such as diabetes mellitus and autoimmune diseases Patients on other honey-based products for the last 3 months Patient who consumes honey-based products during the study duration of 3 months (monitoring via honey-diary, return of the used sachet during the follow up visits) Patients on anti-oxidants, traditional medications or herbal products for the last 3 months Topical usage of steroids, systemic steroids and non-steroidal anti-inflammatory drugs.\n\nSepsis Compliance less than 75%.","ALL","15 Years","40 Years",{"count":129,"type":130},60,"ESTIMATED","INTERVENTIONAL",[133],"PHASE4","The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients. The study evaluates the effects on serum Interleukin 6 level(IL-6), retinal nerve fiber layer(RNFL) thickness and dry eye-related symptoms. A total of 60 participants who meet the study criteria will be randomly assigned to one of two groups. One group will consume 30 grams of Kelulut honey daily for a period of three months, while the control group will not receive honey or a placebo. Serum IL-6 level, RNFL thickness, Tear break up time (TBUT) and Schirmer Test 1 will be done before and after 90 days. Adherence to honey consumption will be monitored using a daily diary. This study aims to provide better understanding of the potential role of Kelulut honey as a supplementary therapy in patients with juvenile open-angle glaucoma.",[136,137,138,139,140],"Juvenile Open Angle Glaucoma","Dry Eye Disease (DED)","Interleukin 6","Retinal Nerve Fiber Layer Thickness","HbA1c Level","2026-02-03",{"date":143,"type":144},"2026-02-09","ACTUAL",{"date":146,"type":144},"2026-01-15",{"date":148,"type":130},"2026-06-30",{"name":5,"class":6},4]