[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571056":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":40,"collaborators":19,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":19,"enrollmentInfo":54,"targetDuration":19,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Patients with Chronic Thromboembolic Pulmonary Hypertension","Patients with Chronic Thromboembolic Pulmonary Hypertension under Sildenafil treatment",[12],"Drug: Riociguat (Adempas)",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DRUG","Riociguat (Adempas)","Oral riociguat administered according to established dose-adjustment scheme. Riociguat will be administered starting at at 1mg three times per day. If patient systolic blood pressure maintains at 95mmHg or higher, the dose will be increased 0.5mg every 2 weeks up to a maximum dose 2.5mg three times per day over 8-week period",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Daniel Xu Nurse","CONTACT","+85235051518","danielxu@cuhk.edu.hk",[27],{"facility":28,"status":29,"city":30,"state":19,"zip":19,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Prince of Wales Hospital","RECRUITING","Hong Kong","HK",{"type":33,"coordinates":34},"Point",[35,36],114.17469,22.27832,{"lat":36,"lon":35},[39],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},{"type":41,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","GuangMing Tan","Professor","100571056","phase-4-switching-of-sildenafil-to-riociguat-in-cteph-patients-100571056",false,"NCT06715280","Switching of Sildenafil to Riociguat in CTEPH Patients","Switching Sildenafil to Riociguat in Chronic Thromboembolic Pulmonary Hypertension After Balloon Pulmonary Angioplasty","S2R","Inclusion Criteria:\n\n1. Patients with established diagnosis of CTEPH who are symptomatic after Balloon pulmonary angioplasty (BPA)\n2. Patients who are on stable maximally tolerated dose of sildenafil for at least 6 weeks as monotherapy, or in combination with other pulmonary hypertension specific therapies\n3. WHO functional class III at screening\n4. Stable dose of diuretics (if used) for at least 30 days at screening\n5. No recent hospitalisation due to pulmonary hypertension or heart failure for at least 30 days\n\nExclusion Criteria:\n\n1. Previous treatment with riociguat other sGCs, or documented severe drug reaction or intolerance to sGCs\n2. Use of nitrates or nitric oxide donors (eg, nitroglycerin, amyl nitrite, isosorbide dinitrate etc) by any administration routes within 30 days of screening\n3. Pregnant women or breast-feeding women, or women with childbearing potential not using of combination of two effective contraception methods throughout study\n4. Renal impairment with glomerular filtration rate \\\u003C15mL \u002Fmin\n5. Child-Pugh C hepatic impairment","ALL","18 Years",{"count":55,"type":56},30,"ESTIMATED","INTERVENTIONAL",[59],"PHASE4","This study was designed to investigate the safety and efficacy of replacing phosphodiesterase 5 inhibitors (PDE5i) with riociguat in patients with Chronic thromboembolic pulmonary hypertension (CTEPH) who have undergone pulmonary angioplasty (BPA) and remains symptomatic despite treatments with PDE5i.",[62],"Chronic Thromboembolic Pulmonary Hypertension",[64,65,66,67],"CTEPH","BPA","Riociguat","Sildenafil","2025-05-23",{"date":70,"type":71},"2025-05-29","ACTUAL",{"date":73,"type":71},"2024-07-25",{"date":75,"type":56},"2027-01-22",{"name":5,"class":6},1]