[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524471":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":34,"locations":46,"responsibleParty":70,"collaborators":33,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":33,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":33,"enrollmentInfo":81,"targetDuration":33,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":33,"overallStatus":48,"whyStopped":33,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Taichung Veterans General Hospital","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"High dose tranexamic acid + high ACT level","ACTIVE_COMPARATOR","high dose tranexamic acid: 50mg\u002Fkg ACT level: \\> 600 sec",[13],"Drug: Tranexamic acid",{"label":15,"type":10,"description":16,"interventionNames":17},"High dose tranexamic acid + low ACT level","high dose tranexamic acid: 50mg\u002Fkg ACT level: 400\\~ 600 sec",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Low dose tranexamic acid + low ACT level","Low dose tranxeamic acid: 20mg\u002Fkg ACT level: 400\\~ 600 sec",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"Low dose tranexamic acid + high ACT level","PLACEBO_COMPARATOR","Low dose tranxeamic acid: 20mg\u002Fkg ACT level: \\> 600 sec",[13],[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Tranexamic acid","tranexamic acid will be used in two different doses (50mg\u002Fkg vs 20mg\u002Fkg). the tranexamic acid pump will start from the begin of anesthesia until all dose is administrated.",[9,15,23,19],null,[35,41],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Yung-Szu Wu, MD","CONTACT","0423592525","5063","adconvert98@gmail.com",{"name":42,"role":37,"phone":43,"phoneExt":44,"email":45},"Yi-Ting Chang, MD","04-23592525","5062","alisonytchang@gmail.com",[47,62],{"facility":5,"status":48,"city":49,"state":33,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Taichung","40705","Taiwan","TW",{"type":54,"coordinates":55},"Point",[56,57],120.6839,24.1469,{"lat":57,"lon":56},[60],{"name":61,"role":37,"phone":33,"phoneExt":33,"email":33},"Yung-Szu Wu",{"facility":63,"status":48,"city":49,"state":33,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Taichung Veterans General hospital",{"type":54,"coordinates":65},[56,57],{"lat":57,"lon":56},[68],{"name":69,"role":37,"phone":33,"phoneExt":33,"email":33},"Yung Szu Wu",{"type":71,"investigatorFullName":33,"investigatorTitle":33,"investigatorAffiliation":33,"oldNameTitle":33,"oldOrganization":33},"SPONSOR","100524471","phase-4-the-effect-of-act-and-tranexamic-acid-on-bleeding-in-cardiac-surgery-100524471",false,"NCT06109155","The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery","The Dose Effect of Activated Clotting Time and Tranexamic Acid on Bleeding in Adult Cardiac Surgery","Inclusion Criteria:\n\n* adult, cardiac surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* pregnant\n* emergency procedure\n* immune compromised\n* aortic surgery\n* end-stage renal disease\n* liver disease\n* critical status\n* incomplete clinical data","ALL","18 Years",{"count":82,"type":83},150,"ESTIMATED","INTERVENTIONAL",[86],"PHASE4","The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery.\n\nThe main questions it aims to answer are:\n\n1. Does higher dose of tranexamic acid reduce the amount of bleeding and blood transfusion?\n2. Does lower ACT level during cardiac surgery reduce the amount of bleeding and blood transfusion?\n\nParticipants will divided into four groups which have different tranexamic acid dose and ACT level during cardiac surgery to see if there is any different in the amount of bleeding and blood transfusion.",[89,90,91,92,93],"Surgery, Cardiac","Tranxemic Acid","Activated Clotting Time","Heparin","Cardiopulmonary Bypass","2024-02-20",{"date":96,"type":97},"2024-02-21","ACTUAL",{"date":99,"type":97},"2024-02-08",{"date":101,"type":83},"2026-12-31",{"name":5,"class":6},2]