[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545177":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":36,"collaborators":25,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":25,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":25,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":25,"overallStatus":59,"whyStopped":25,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":25},{"fullName":5,"class":6},"Universita degli Studi di Genova","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Long-span therapy","EXPERIMENTAL","1 g Amoxicillin every 8 h starting 1 day before surgery and for 5 days after surgery",[13],"Drug: Amoxicillin Long",{"label":15,"type":10,"description":16,"interventionNames":17},"Short-span therapy","2 g Amoxicillin 1 h before surgery",[18],"Drug: Amoxicillin Short",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Amoxicillin Short","Short Span",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Amoxicillin Long","Long span",[9],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Maria Menini","CONTACT","3396598789‬","maria.menini@unige.it",{"type":37,"investigatorFullName":32,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Prof","100545177","phase-4-the-effect-of-different-antibiotic-protocols-on-peri-implant-tissue-health-100545177",false,"NCT06378502","The Effect of Different Antibiotic Protocols on Peri-implant Tissue Health","The Effect of Different Antibiotic Protocols for Dental Implant Surgery on Peri-implant Tissue Health and on Oral Microbiome and Resistome","Inclusion Criteria:\n\nHealthy volunteers requiring one single implant or partial implant-supported rehabilitation in an edentulous area of the posterior mandible or maxilla\n\nExclusion Criteria:\n\n* Patients unable to commit to follow-up\n* General contraindications to implant surgery\n* Immuno-suppressed\u002Fimmune-compromised patients\n* Patients irradiated in the head and\u002For neck\n* Uncontrolled diabetes\n* Pregnancy, childbearing potential, breastfeeding\n* Smoking habit\n* Untreated periodontal disease (Caton et al, J Clin Periodontol 2018)\n* Poor oral hygiene and motivation (plaque index \\> 20%)\n* Addiction to alcohol or drugs\n* Psychiatric problems and\u002For unrealistic expectations\n* Patients with an acute infection (abscess) or suppuration in the site intended for implant placement\n* Patients treated or under treatment with intravenous amino-bisphosphonates\n* Patients referred only for implant placement if the follow-up cannot be done at the treatment center\n* Patients participating in other studies, if the present protocol could not be fully adhered to\n* Patients with allergy\u002Fhypersensitivity to penicillin or drug excipients\n* Patients recently treated with antibiotics for other indications",true,"ALL","35 Years","65 Years",{"count":51,"type":52},80,"ESTIMATED","INTERVENTIONAL",[55],"PHASE4","The aim of the present project (non-inferiority trial) is to evaluate the effect of different antibiotic strategies (long-span vs. short-span) for implant surgery on peri-implant tissue health, oral microbiome (included resistome) and salivary MiRNomics in healthy patients.",[58],"Antibiotic","NOT_YET_RECRUITING","2024-04-17",{"date":62,"type":63},"2024-04-22","ACTUAL",{"date":65,"type":52},"2024-05-03",{"date":67,"type":52},"2026-06-30",{"name":5,"class":6}]