[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534222":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":50,"collaborators":53,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":12,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":12,"overallStatus":36,"whyStopped":12,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","NO_INTERVENTION","patients with dilated cardiomyopathy infected with Kaposi sarcoma-associated virus to receive standard DCM therapy",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Sirolimus","EXPERIMENTAL","patients with dilated cardiomyopathy infected with Kaposi sarcoma-associated virus to receive sirolimus (at a dose of 2 mg once daily) in addition to standard DCM therapy",[18],"Drug: Sirolimus",[20],{"type":21,"name":14,"description":22,"armGroupLabels":23,"otherNames":12},"DRUG","at a dose of 2 mg once daily",[14],[25],{"name":26,"affiliation":5,"role":27},"Dao Wen Wang, Doctor","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},"Yanru Zhao, Doctor","CONTACT","86-027-83663280","zyrecho@163.com",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Wuhan","Hubei","430030","China","CN",{"type":43,"coordinates":44},"Point",[45,46],114.26667,30.58333,{"lat":46,"lon":45},[49],{"name":30,"role":31,"phone":32,"phoneExt":12,"email":33},{"type":27,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Dao Wen Wang","Prof.",[54,56,59],{"name":55,"class":6},"Wuhan Central Hospital",{"name":57,"class":58},"Wuhan Fourth Hospital","UNKNOWN",{"name":60,"class":6},"Wuhan University","100534222","phase-4-the-effects-of-sirolimus-in-patients-with-dilated-cardiomyopathy-infected-with-kaposi-sarcoma-associated-virus-100534222",false,"NCT06236022","The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated Virus","SDCMK","Inclusion Criteria:\n\n* 18 to 70 years of age;\n* Diagnosed as dilated cardiomyopathy. Specifically, (i) left ventricular ejection fraction \\\u003C45% (\\>2 SD) and\u002For fractional shortening \\\u003C25% (\\>2 SD), as ascertained by echocardiography, radionuclide scanning, or cardiac magnetic resonance imaging; (ii) left ventricular end-diastolic diameter \\>117% of the predicted value corrected for age and body surface area (Henry's formula), which corresponds to 2 SD of the predicted normal limit +5%; and (iii) In the absence of severe coronary artery disease or valvular disease.\n* KSHV DNA seropositivity;\n* Patients are voluntary and signed informed consent.\n\nExclusion Criteria:\n\n* Allergic to rapamycin or its derivatives；\n* The proportion of neutrophils less than 0.5\\*10\\^9\u002FL or platelet less than 2.5\\*10\\^10\u002FL;\n* Pregnant women or plan to;\n* Participate in any drug clinical trials within 3 months;\n* Serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients);\n* Previous history of cancer or tumor, or pathological examination confirmed precancerous lesions;\n* Patients were not optimally managed.","ALL","18 Years","70 Years",{"count":72,"type":73},276,"ESTIMATED","INTERVENTIONAL",[76],"PHASE4","Evaluating the efficacy of sirolimus (compared to standard therapy alone) in the treatment of dilated cardiomyopathy infected with Kaposi Sarcoma-associated virus -- a multicenter randomized controlled study.",[79,80],"Dilated Cardiomyopathy","Kaposi's Sarcoma-Associated Herpesvirus Infection","2024-01-24",{"date":83,"type":84},"2024-02-01","ACTUAL",{"date":86,"type":84},"2024-01-01",{"date":88,"type":73},"2028-12-31",{"name":5,"class":6},1]