[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630450":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":71,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":25,"enrollmentInfo":87,"targetDuration":25,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":101,"whyStopped":25,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sodium tablets first","EXPERIMENTAL","Participants will be randomized to receive sodium tablets for weeks 2-6, no tablets for a washout period during weeks 7-8, then placebo tablets for weeks 9-13.",[13,14],"Drug: Sodium chloride tablets","Other: Placebo Tablets",{"label":16,"type":10,"description":17,"interventionNames":18},"Placebo tablets first","Participants will be randomized to receive placebo tablets for weeks 2-6, no tablets for a washout period during weeks 7-8, then sodium tablets for weeks 9-13.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Sodium chloride tablets","During the 5-week long sodium tablet intervention period, participants will receive five 1 g sodium chloride tablets each morning and four 1 g sodium chloride tablets each evening. Each sodium chloride tablet will contain 0.394 g or 17 mmol of sodium",[16,9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo Tablets","During the 5-week long placebo period, participants will receive five placebo tablets each morning and four placebo tablets each evening.",[16,9],[31],{"name":32,"affiliation":5,"role":33},"Katrina Abuabara, MD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Alicia Hamblin","CONTACT","925-549-7889","Alicia.Hamblin@ucsf.edu",{"name":32,"role":37,"phone":41,"phoneExt":25,"email":42},"415-514-9769","katrina.abuabara@ucsf.edu",[44,61],{"facility":45,"status":25,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"UCSF Mt Zion Campus","San Francisco","California","94115","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-122.41942,37.77493,{"lat":55,"lon":54},[58,59,60],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":37,"phone":25,"phoneExt":41,"email":42},{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"facility":62,"status":25,"city":46,"state":47,"zip":63,"country":49,"countryCode":50,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"San Francisco VA Medical Center","94121",{"type":52,"coordinates":65},[54,55],{"lat":55,"lon":54},[68,69,70],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":37,"phone":41,"phoneExt":25,"email":42},{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"type":72,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[74],{"name":75,"class":76},"LEO Foundation","UNKNOWN","100630450","phase-4-the-impact-of-salt-intake-on-sodium-in-the-skin-and-inflammatory-skin-disease-100630450",false,"NCT07487831","The Impact of Salt Intake on Sodium in the Skin and Inflammatory Skin Disease","SIS-ISD","Inclusion Criteria:\n\n* Participants ages 18 years\n* Willing and able to undergo non-contrast MRI.\n\nExclusion Criteria:\n\n* Contraindications to MRI (such as cardiac pacemakers, claustrophobia, non-compatible intracranial vascular clips, IUDs, or other implants)\n* A cardiac event in the past 6 months\n* Impaired function of the liver or kidney (glomerular filtration rate \\\u003C60 mL\u002Fmin)\n* Medications that influence sodium excretion (e.g., diuretics or SGLT2 inhibitors)\n* Antibiotic or immunomodulatory medications within the last month\n* Contraindications to sodium tablets\n\n(Topical medications used exclusively on the head\u002Fneck or hands\u002Ffeet (e.g., antifungal nail treatment, antidandruff shampoo, acne cleansers) are acceptable. Topical and systemic eczema treatments are acceptable if the participant has been on a stable dose for at least 2 months and still meets the severity entry criteria. Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the disease severity inclusion criteria.)",true,"ALL","18 Years",{"count":88,"type":89},50,"ESTIMATED","INTERVENTIONAL",[92],"PHASE4","The goal of this clinical trial is to demonstrate the feasibility of a trial that examines the impact of changes in dietary sodium intake on skin sodium levels, atopic dermatitis, and psoriasis. In addition, it aims to generate preliminary data to begin to answer the following questions:\n\n1. Is there an association between skin sodium concentration and atopic dermatitis and psoriasis severity?\n2. Are changes in dietary sodium are associated with changes in skin sodium concentration and atopic dermatitis and psoriasis severity?\n\nResearchers will compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake.\n\nParticipants will:\n\n* Follow a low-salt diet for the duration of the 13-week study\n* Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa\n* Visit the clinic up to 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI",[95,96],"Atopic Dermatitis (Eczema)","Psoriasis",[98,99,100],"sodium","salt","diet","NOT_YET_RECRUITING","2026-06-05",{"date":104,"type":105},"2026-06-09","ACTUAL",{"date":107,"type":89},"2026-06-22",{"date":109,"type":89},"2028-03-17",{"name":5,"class":6},2]