[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570489":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":27,"locations":36,"responsibleParty":51,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":18,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":18,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":18,"overallStatus":39,"whyStopped":18,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Menaquinone group","ACTIVE_COMPARATOR","Tooth extraction will perform under local anesthesia All sockets were thoroughly curetted to remove granulation tissue, followed by irrigation and rinsing with sterile saline. the socket will be filled with crushed capsule of vitamin k2(menaquinone) and cover with an absorbent sponge a Figure of eight tension-free non-resorbable 3-0 sutures will be placed over the filled socket to stabilize the graft material in the socket and to achieve soft tissue stability.\n\nBone density and socket dimensions will be evaluated immediately after extraction with graft material and after 4 months by using a cone beam computed tomography (CBCT) radiograph and at the time of implant placement core biopsy will be taken for histomorphometric analysis.",[13],"Drug: Menaquinone",{"label":15,"type":16,"description":17,"interventionNames":18},"control group","NO_INTERVENTION","Tooth extraction will perform under local anesthesia All sockets were thoroughly curetted to remove granulation tissue, followed by irrigation and rinsing with sterile saline. the socket will be left to heal without grafting, and it will be covered with an absorbent sponge. A figure-of-eight tension-free non-resorbable 3-0 sutures will be placed over the socket.\n\nBone density and socket dimensions will be evaluated immediately after extraction with graft material and after 4 months by using a cone beam computed tomography (CBCT) radiograph and at the time of implant placement core biopsy will be taken for histomorphometric analysis.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Menaquinone","the socket will be filled with crushed capsule of vitamin k2 menaquinone in study group",[9],[26],"vitamin k2 (Menaquinone)",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":18,"email":32},"mohamed elsawaf, BDS","CONTACT","01124145951","mohamed.elsawaf@dentistry.cu.edu.eg",{"name":34,"role":30,"phone":35,"phoneExt":18,"email":18},"mohamed Khashaba, Professor","01094331092",[37],{"facility":38,"status":39,"city":38,"state":40,"zip":18,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Cairo","RECRUITING","Cairo Governorate","Egypt","EG",{"type":44,"coordinates":45},"Point",[46,47],31.24967,30.06263,{"lat":47,"lon":46},[50],{"name":29,"role":30,"phone":31,"phoneExt":18,"email":32},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Mohamed Hussien Mohamed Elsawaf","Principal Investigator","100570489","phase-4-the-local-effect-of-vitamin-k2-on-bone-remodeling-in-socket-preservation-100570489",false,"NCT06707909","The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation","The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation of Mandibular Single Rooted Teeth Randomized Clinical Trail","Inclusion Criteria:• Age \\> 18 years without other age or gender restrictions.\n\n* Patients requiring extraction of mandibular single-rooted teeth.\n\nExclusion Criteria:\n\n* • Patients with systemic conditions affecting bone metabolism.\n\n  * Allergies or sensitivities to hydroxyapatite or Vitamin K2\n  * Untreated or residual periodontal disease;\n  * Uncontrolled diabetes (HbA1c \\> 7.5%);\n  * Head and\u002For neck radiotherapy\n  * Immunosuppressive therapy\n  * Pregnant or nursing\n  * Substance abuse\n  * Treated or under treatment with intravenous amino-bisphosphonates\n  * Patients participating in other studies, if the present protocol could not be properly followed.",true,"ALL","18 Years","80 Years",{"count":67,"type":68},20,"ESTIMATED","INTERVENTIONAL",[71],"PHASE4","This study is a randomized controlled trial comparing the effects of socket grafting with crushed vitamin K2 (menaquinone)capsules versus no grafting on bone density and socket dimensions following tooth extraction. Patients are randomly assigned to one of two groups:\n\nStudy Group (Group I): Patients receive socket grafting with crushed vitamin K2 (menaquinone) capsules. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed to stabilize the graft material and achieve soft tissue stability.\n\nControl Group (Group II): Patients undergo socket healing without grafting. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed over it.\n\nOutcome measures include bone socket dimensions evaluated immediately after extraction with graft material, as well as assessment after 4 months using cone beam computed tomography (CBCT) radiographs. Additionally, core biopsies are taken at the time of implant placement.",[74],"Socket Preservation","2025-02-02",{"date":77,"type":78},"2025-02-05","ACTUAL",{"date":80,"type":68},"2025-02-15",{"date":82,"type":68},"2025-11-24",{"name":5,"class":6},1]