[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525990":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":51,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":19,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":19,"enrollmentInfo":64,"targetDuration":19,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"State University of New York at Buffalo","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Vaccination with Prevnar.","EXPERIMENTAL","Intramuscular vaccination with Prevnar 20",[13],"Other: vaccine",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"vaccine","Vaccination against 20 serotypes of S. pneumoniae",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Elsa N Bou Ghanem, PhD","University at Buffalo","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Elsa Bou Ghanem, PhD","CONTACT","7168292422","elsaboug@buffalo.edu",[32],{"facility":23,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Buffalo","New York","14203","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-78.87837,42.88645,{"lat":43,"lon":42},[46],{"name":47,"role":28,"phone":19,"phoneExt":19,"email":19},"Catherine Wrona",{"type":24,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Elsa Bou Ghanem","Principal Investigator",[52],{"name":53,"class":54},"National Institute on Aging (NIA)","NIH","100525990","phase-4-the-role-of-neutrophils-in-the-age-driven-decline-in-anti-pneumococcal-vaccine-responses-100525990",false,"NCT06128915","The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses","Inclusion Criteria:\n\n* Both sexes\n* Have not been vaccinated with any licensed or experimental pneumococcal vaccine\n* Ages 21-40; and ≥65. Individuals \\>60 years old will also be recruited in case we find no unvaccinated people ≥65 years old\n* Free of acute infections within the last 2 weeks\n* Did not take any anti-inflammatory medicine in the last week\n* Did not ingest alcohol in the last 24 hours\n* Ability and willingness to provide consent\n\nExclusion Criteria:\n\n* Previous vaccination with any licensed or experimental pneumococcal vaccine\n* Known hypersensitivity to vaccination and vaccine components\n* Immune deficiency\n* Use of immune-modulating or suppressive drugs\n* Malignancies within the last 2 years\n* Known hematological, rheumatic and inflammatory diseases\n* Known chronic infections\n* Poorly controlled chronic cardiovascular and metabolic conditions\n* Pregnancy\n* Dementia",true,"ALL","21 Years",{"count":65,"type":66},60,"ESTIMATED","INTERVENTIONAL",[69],"PHASE4","This study focuses on the role of neutrophils in shaping the adaptive immune response to the anti-pneumococcal vaccine Prevnar-13 in young and elderly adults.",[72],"Aging",[72,74,75,76],"Neutrophils","Streptococcus pneumoniae","Pneumococcal conjugate vaccine","2026-04-02",{"date":79,"type":80},"2026-04-03","ACTUAL",{"date":82,"type":80},"2024-01-08",{"date":84,"type":66},"2027-05-31",{"name":5,"class":6},1]