[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587357":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":36,"locations":42,"responsibleParty":58,"collaborators":30,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":30,"eligibilityCriteria":66,"healthyVolunteers":63,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":30,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":30,"overallStatus":81,"whyStopped":30,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"The Second Affiliated Hospital of Kunming Medical University","OTHER",[8,15,20],{"label":9,"type":10,"description":11,"interventionNames":12},"tDCS combined with XingNaoJing treatment group","EXPERIMENTAL","The tDCS stimulation time was 20 minutes, once a day, 5 times a week, a total of 10 times, the stimulation intensity was 2mA, and the stimulation site was the cerebellum. The dosage of Xingnaojing was 20 ml each time by intravenous drip, diluted with 9% sodium chloride injection 200 ml, once a day. Intervention for two weeks.",[13,14],"Drug: XinNaoJing injection","Device: tDCS",{"label":16,"type":17,"description":18,"interventionNames":19},"tDCS treatment group","SHAM_COMPARATOR","The tDCS stimulation time was 20 minutes, once a day, 5 times a week, a total of 10 times, and the stimulation intensity was 2mA.",[14],{"label":21,"type":17,"description":22,"interventionNames":23},"XingNaoJing treatment group","The dosage of XingNaoJing was 20 ml each time by intravenous drip, diluted with 9% sodium chloride injection 200 ml, once a day.",[13],[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","XinNaoJing injection","XingNaoJing injection is a kind of traditional Chinese medicine preparation, which has the effects of clearing heat and detoxifying, cooling blood and activating blood circulation, resuscitating the brain. In recent years, it has been often used in the treatment of related symptoms caused by qi and blood disturbance and cerebral blood stasis, and has achieved certain results. Xingnaojing injection contains Yujin to resuscitate phlegm, invigorate blood circulation and promote qi; Zhizi dissipates blood stasis and cleans heat; Both are subject medicine. Natural musk cleans the brain, Shujin Tongluo, Jun medicine; Borneol awaken awaken, for adjuvant. Small doses of musk restored brain function and improved cerebral circulation. Xingnaojing injection can promote the recovery of consciousness, reduce the level of plasma β-endorphin, and restore brain function. Borneol bi-dimensionally regulates the central nervous system, calms, prolongs the level of arousal, and protects the brain tissue.",[21,9],null,{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":30},"DEVICE","tDCS","tDCS stimulated the cerebellum for 20 minutes, once a day, 5 times a week, a total of 10 times, and the stimulation intensity was 2mA.",[9,16],[37],{"name":38,"role":39,"phone":40,"phoneExt":30,"email":41},"Liqing Yao","CONTACT","+8613529202383","yaoliqing98731@163.com",[43],{"facility":44,"status":30,"city":45,"state":46,"zip":30,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Electroencephalography","Kunming","Yunnan","China","CN",{"type":50,"coordinates":51},"Point",[52,53],102.71833,25.03889,{"lat":53,"lon":52},[56],{"name":57,"role":39,"phone":40,"phoneExt":30,"email":41},"Yao",{"type":59,"investigatorFullName":38,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Department of rehabilitation medicine, the Second Affiliated Hospital of Kunming Medical University","100587357","phase-4-the-study-on-the-efficacy-of-tdcs-stimulation-of-the-cerebellum-combined-with-xingnaojing-injection-in-patients-with-consciousness-disorders-after-cranial-injury-100587357",false,"NCT06927336","The Study on the Efficacy of tDCS Stimulation of the Cerebellum Combined With XingNaoJing Injection in Patients With Consciousness Disorders After Cranial Injury","Inclusion Criteria:\n\n1. aged 18-80 years;\n2. All patients met the diagnostic criteria of DoC;\n3. more than 1 month after the initial head injury;\n4. stable consciousness for at least 2 weeks before admission (no change in CRS-R total score);\n5. no skull defect or large area of skull repair;\n6. The legal representative authorized by the patient approved the experimental protocol and signed the informed consent form.\n\nExclusion Criteria:\n\n1. supratentorial abnormalities on computed tomography (CT) or magnetic resonance imaging (MRI) involving more than one third of the middle cerebral artery territory;\n2. a life expectancy of less than 3 months or a follow-up of less than 3 months;\n3. retention of intracranial metal objects, cranial debridement, or presence of cranial defects and any clinically significant or unstable medical diseases;\n4. EEG recording with significant muscle artifacts and inhibitory bursts;\n5. nonconvulsive status epilepticus; Periodic or burst rhythms evoked by stimulation;\n6. disturbance of consciousness due to surgical injury or tumor.","ALL","18 Years","80 Years",{"count":71,"type":72},200,"ESTIMATED","INTERVENTIONAL",[75],"PHASE4","The purpose of this study is to investigate the effect of tDCS stimulation of cerebellum combined with Xingnaojing on patients with disturbance of consciousness after craniocerebral injury, and to clarify the relationship between the following two points: (1) to clarify whether MMN, P300, fNIRS, BAEP, SEP can be used as objective indicators to distinguish VS from MCS. (2) To clarify the changes of consciousness level and brain function in DoC patients with craniocerebral injury treated with tDCS stimulation of cerebellum combined with Xingnaojing.",[33,78,79,80],"Cerebellum","Brain Injury","Disturbance of Consciousness","NOT_YET_RECRUITING","2025-04-14",{"date":84,"type":85},"2025-04-15","ACTUAL",{"date":87,"type":72},"2025-04-25",{"date":89,"type":72},"2026-12-30",{"name":5,"class":6},1]