[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629295":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":37,"responsibleParty":65,"collaborators":26,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":92,"whyStopped":26,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Cairo University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-cultured epidermal cell suspension surgery with Mini-Oral Pulse Steroid Therapy","ACTIVE_COMPARATOR","Participants will receive low-dose oral mini-pulse dexamethasone (5 mg\u002Fweek given on two consecutive days) for 4 weeks before and 4 weeks after undergoing non-cultured epidermal cell suspension (NCES) surgery for stable vitiligo lesions. After healing, participants will receive excimer laser sessions twice weekly and will be followed for 4 months to assess repigmentation, development of perilesional halo, and treatment safety.",[13,14,15],"Procedure: Non-cultured epidermal cell suspension (NCES) surgery","Drug: Oral mini pulse","Device: Excimer Sessions",{"label":17,"type":6,"description":18,"interventionNames":19},"Non-cultured epidermal cell suspension Surgery Alone","Participants will undergo non-cultured epidermal cell suspension (NCES) surgery for stable vitiligo lesions without oral mini-pulse steroid therapy. After healing, participants will receive excimer laser sessions twice weekly and will be followed for 4 months to evaluate repigmentation outcomes and development of perilesional halo.",[13,15],[21,27,32],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Non-cultured epidermal cell suspension (NCES) surgery","Under aseptic precautions and local anesthesia, a Thiersch graft with a donor-to-recipient ratio of 1:3 will be harvested from the donor site (usually upper thigh\u002F buttocks).\n\nThe skin graft will be transferred to trypsin-EDTA solution and incubated at 37 °C for 20-30 minutes to separate epidermis from the dermis, and then washed with lactated Ringer. The tissue will be teased gently with sterile forceps to release epidermal cells from the trypsin-digested graft. The white dermis will be removed, and the suspension will be centrifuged at 1000g for 5-10 minutes, and the supernatant will be discarded.",[17,9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DRUG","Oral mini pulse","Oral mini-pulse steroids (low-dose dexamethasone: 5mg\u002Fweek on 2 successive days per week) for 4 weeks before NCES and for 4 weeks afterward.",[9],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":26},"DEVICE","Excimer Sessions","Patients will start Excimer sessions 2 times per week for 4 months after complete healing.",[17,9],[38],{"facility":39,"status":26,"city":40,"state":26,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Dermatology out patient clinic, Faculty of Medicine, Cairo University","Cairo","11562","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.24967,30.06263,{"lat":48,"lon":47},[51,56,59,62,63],{"name":52,"role":53,"phone":54,"phoneExt":26,"email":55},"Lobna Alieldin, Lecturer of Dermatology","CONTACT","+201002279968","Lobnaalieldin@cu.edu.eg",{"name":57,"role":58,"phone":26,"phoneExt":26,"email":26},"Samia Esmat, Professor of Dermatology","PRINCIPAL_INVESTIGATOR",{"name":60,"role":61,"phone":26,"phoneExt":26,"email":26},"Rania Mogawer, Associate professor of Dermato","SUB_INVESTIGATOR",{"name":52,"role":61,"phone":26,"phoneExt":26,"email":26},{"name":64,"role":61,"phone":26,"phoneExt":26,"email":26},"Shrouq El-Essawy, Resident of Dermatology",{"type":58,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Lobna Gamal Alieldin","Lecturer","100629295","phase-4-the-value-of-adding-mini-oral-pulse-steroid-therapy-in-preventing-peri-lesional-halo-post-non-cultured-epidermal-cell-suspension-nces-in-cases-with-stable-segmental-and-non-acral-vitiligo-100629295",false,"NCT07472816","The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo.","The Value of Adding Mini-oral Pulse Steroid Therapy in Preventing Peri-lesional Halo Post Non-cultured Epidermal Cell Suspension (NCES) in Cases With Stable Segmental and Non-acral Vitiligo: An Interventional Prospective Randomized Controlled Trial.","Inclusion criteria:\n\n* Patients with segmental vitiligo lesions that are not responsive to conventional treatment.\n* Patients with non-Acral vitiligo lesions that are not responsive to conventional treatment and on sites known to be responsive to surgery, like the face and trunk.\n* Stability for ≥ 1 year.\n* Age ≥12 years.\n* Lack of systemic and topical treatment for at least 3 months prior inclusion in the study.\n\nExclusion criteria:\n\n* Acral vitiligo.\n* Segmental vitiligo lesions that are responsive to conventional treatment.\n* Non acral vitiligo lesions on sites that are knowingly not responsive to surgery, like knees and elbows.\n* Active vitiligo; new lesions, expansion of old lesions, confetti like lesions, ill-defined edges, hypochromia, depigmentation of previously pigmented areas or koebnerization in \\\u003C 1 year.\n* Age \\\u003C 12 years.\n* Pregnant females.\n* Patients with contraindication to systemic steroid like uncontrolled hypertension, diabetes or tuberculosis\n* Systemic and topical treatment in the past 3 months.","ALL","12 Years",{"count":78,"type":79},60,"ESTIMATED","INTERVENTIONAL",[82],"PHASE4","The goal of this clinical trial is to learn if adding mini-oral pulse steroid therapy improves the results of non-cultured epidermal cell suspension (NCES) surgery in patients with stable vitiligo. It will also evaluate the safety of this treatment approach. The main questions it aims to answer are:\n\n* Does adding mini-oral pulse steroid therapy reduce the development of a perilesional halo after NCES surgery?\n* Does the addition of steroids improve the degree of repigmentation and overall treatment outcomes in vitiligo lesions?\n\nResearchers will compare NCES surgery with mini-oral pulse steroids to NCES surgery alone to determine whether the steroid therapy improves surgical outcomes.\n\nParticipants will:\n\n* Undergo NCES vitiligo surgery for stable segmental or non-acral vitiligo lesions.\n* Be randomly assigned to receive either surgery alone or surgery plus low-dose oral mini-pulse dexamethasone therapy.\n* Attend follow-up visits and clinical assessments for approximately 4 months.\n* Receive excimer laser sessions twice weekly after healing and have standardized photographs and scoring assessments to evaluate repigmentation.",[85],"Vitiligo",[87,85,88,89,90,91],"non-cultured epidermal cell suspension","Segmental","non-acral","Mini-oral pulse steroid","peri-lesional halo","NOT_YET_RECRUITING","2026-03-12",{"date":95,"type":96},"2026-03-16","ACTUAL",{"date":98,"type":79},"2026-03-15",{"date":100,"type":79},"2026-07-01",{"name":5,"class":6},1]