[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545634":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":54,"collaborators":25,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":25,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Topical TRanexamic Acid","EXPERIMENTAL","10mL of 100mg\u002FmL TXA in addition to the standard care",[13],"Drug: Topical TRanexamic Acid",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","10mL of 100mg\u002FmL normal saline in addition to the standard care",[19],"Drug: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","10mL of 100mg\u002FmL TXA will be administered into the surgical wound prior closure.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"10mL of 100mg\u002FmL normal saline will be administered into the surgical wound prior closure.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Ryan Paul","CONTACT","416-603-5839","jhanna.bermudez@uhn.ca",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Toronto Western Hospital","RECRUITING","Toronto","Ontario","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-79.39864,43.70643,{"lat":47,"lon":46},[50],{"name":51,"role":32,"phone":52,"phoneExt":25,"email":53},"Ryan Paul, MD","416-603-5641","ryan.paul2@uhn.ca",{"type":55,"investigatorFullName":31,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Dr.","100545634","phase-4-topical-tranexamic-acid-vs-placebo-on-acute-postoperative-pain-following-drf-fixation-100545634",false,"NCT06384456","Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation","The Effect of Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following Distal Radius Fracture Fixation: a Randomized Controlled Trial - The TRADR Study","TRADR","Inclusion Criteria:\n\n* Patients undergoing open reduction internal fixation (Volar approach) for operative management of a distal radius fracture;\n* Aged 18 or older;\n* Provision of informed consent;\n* Cognitive ability and English-language skills required to complete outcome measures.\n\nExclusion Criteria:\n\n* Revision surgery or any additional operative management of ipsilateral wrist injury\n* Distal radius fracture treated with a dorsal approach\n* Known history of lymphedema or lymph node dissection in the operative extremity\n* Known chronic pain conditions, fibromyalgia, or polymyalgia rheumatic\n* Current user of opioids and\u002For on chronic opioids use\n* Known allergic reaction to TXA\n* Anticoagulant use not stopped in time for surgery as per thrombosis Canada guidelines (i.e. warfarin, acetylsalicylic acid, direct oral anticoagulants, etc.)\n* Previous thrombotic stroke or thromboembolic disorders (i.e. known previous DVT, PE, or clotting disorders)\n* Current pregnancy or breastfeeding\n* Previous neurologic injury causing paralysis of affected shoulder\u002Farm\n* Severe cardio-respiratory disease (i.e. ASA Grade IV or higher).","ALL","18 Years",{"count":68,"type":69},90,"ESTIMATED","INTERVENTIONAL",[72],"PHASE4","The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).",[75],"Distal Radius Fractures",[75,77,78,79,15,80],"acute pain","Topical tranexamic acid","Open Reduction and Internal FIxation","Randomized Control Trial","2026-04-28",{"date":83,"type":84},"2026-05-04","ACTUAL",{"date":86,"type":84},"2025-08-13",{"date":88,"type":69},"2027-12",{"name":5,"class":6},1]