[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503776":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":27,"locations":33,"responsibleParty":76,"collaborators":79,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":84,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":26,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":26,"overallStatus":36,"whyStopped":26,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"James J. Peters Veterans Affairs Medical Center","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study 1","EXPERIMENTAL","Twenty-five participants will be asked to visit the laboratory on 6 occasions, for an open-label, dose escalation trial to determine the effect of midodrine and droxidopa on supine and seated blood pressure and on symptoms of autonomic dysreflexia and orthostatic hypotension.",[13],"Drug: Midodrine Hydrochloride",{"label":15,"type":10,"description":16,"interventionNames":17},"Study 2","Determine the effects of compression garments, midodrine, and droxidopa, compared to placebo, on orthostatic hemodynamics, symptoms of AD and OH and reporting of fatigue and thermal comfort.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Midodrine Hydrochloride","Determine best drug and dose to increase and stabilize SBP during orthostatic tilt",[9,15],[25],"Droxidopa",null,[28],{"name":29,"role":30,"phone":31,"phoneExt":26,"email":32},"Matt G. Maher, MS","CONTACT","9733243588","matt.maher@va.gov",[34,53],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Kessler Foundation","RECRUITING","West Orange","New Jersey","07052","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-74.23904,40.79871,{"lat":46,"lon":45},[49],{"name":50,"role":30,"phone":51,"phoneExt":26,"email":52},"Matthew T Maher, MS","201-566-0291","MMaher@Kesslerfoundation.org",{"facility":54,"status":36,"city":55,"state":56,"zip":57,"country":40,"countryCode":41,"cosmosGeoPoint":58,"geoPoint":62,"contacts":63},"James J Peters VA Medical Center","The Bronx","New York","10468",{"type":43,"coordinates":59},[60,61],-73.86641,40.84985,{"lat":61,"lon":60},[64,69,73],{"name":65,"role":30,"phone":66,"phoneExt":67,"email":68},"Finn E Fox, BS","718-584-9000","5418","fiona.fox2@va.gov",{"name":70,"role":30,"phone":66,"phoneExt":71,"email":72},"Jorge Chavez, BS","5420","jorge.chavez1@va.gov",{"name":74,"role":75,"phone":26,"phoneExt":26,"email":26},"Jill M Wecht, EdD","PRINCIPAL_INVESTIGATOR",{"type":75,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Jill M. Wecht, Ed.D.","Research Scientist",[80],{"name":35,"class":81},"OTHER","100503776","phase-4-treatment-of-orthostatic-hypotension-in-sci-100503776",false,"NCT05839652","Treatment of Orthostatic Hypotension in SCI","Treatment of Orthostatic Hypotension in Individuals With Spinal Cord Injury","SCI","Inclusion Criteria:\n\n* traumatic spinal cord injury\n* at least 12 months post injury\n* injury level of C1-T6\n* AIS A, B or C\n* non-ambulatory\n* non-ventilator\n\nExclusion Criteria:\n\n* Active psychiatric disorder\n* Stroke or cerebrovascular disease\n* Alzheimer's Disease or dementia\n* Unmanaged cardiac arrhythmias\n* Concurrent systemic, hepatic, or renal disease\n* Suspected or diagnosed malignancy\n* Neurological disease other than SCI\n* Self-reported history of three or more symptomatic episodes of AD per day","ALL","18 Years","60 Years",{"count":94,"type":95},25,"ESTIMATED","INTERVENTIONAL",[98],"PHASE4","The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic hypotension, and levels of fatigue and comfort in hypotensive individuals with SCI.",[101],"Hypotension","2024-09-27",{"date":104,"type":105},"2024-10-01","ACTUAL",{"date":107,"type":105},"2023-07-01",{"date":109,"type":95},"2026-06-30",{"name":5,"class":6},2]