[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543328":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":45,"responsibleParty":67,"collaborators":43,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":43,"enrollmentInfo":79,"targetDuration":43,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":47,"whyStopped":43,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Hospital de Clinicas de Porto Alegre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"letrozole","EXPERIMENTAL","Patients will receive 10mg of letrozole por 7 days.",[13],"Drug: Letrozole tablets",{"label":15,"type":16,"description":17,"interventionNames":18},"Methotrexate","ACTIVE_COMPARATOR","Patients will receive a single intramuscular dose of 100 mg of methotrexate.",[19],"Drug: Methotrexate Sodium",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Letrozole tablets","10 mg of letrozole PO for 7 days",[9],[27],"letrozole 2,5mg - 4 tables",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Methotrexate Sodium","100 mg of methotrexate IM, single dose",[15],[33],"methotrexate intramuscular (IM)",[35],{"name":36,"affiliation":37,"role":38},"Ricardo F Savaris, MD, PhD","Hospital de Clínicas de Porto Alegre","STUDY_CHAIR",[40],{"name":36,"role":41,"phone":42,"phoneExt":43,"email":44},"CONTACT","+55 51 997781966",null,"rsavaris@hcpa.edu.br",[46],{"facility":37,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Porto Alegre","Rio Grande do Sul","90035-903","Brazil","BR",{"type":54,"coordinates":55},"Point",[56,57],-51.23019,-30.03283,{"lat":57,"lon":56},[60,63],{"name":61,"role":41,"phone":62,"phoneExt":43,"email":44},"RICARDO F SAVARIS, MD,PHD","55 51 33598117",{"name":64,"role":41,"phone":65,"phoneExt":43,"email":66},"Michele S Savaris, BBA","555133598624","msavaris@hcpa.edu.br",{"type":68,"investigatorFullName":43,"investigatorTitle":43,"investigatorAffiliation":43,"oldNameTitle":43,"oldOrganization":43},"SPONSOR","100543328","phase-4-use-of-letrozole-for-ectopic-pregnancy-100543328",false,"NCT06354439","Use of Letrozole for Ectopic Pregnancy","Use of Letrozole in the Treatment of Early Ectopic Pregnancy","EcZOL","Inclusion Criteria:\n\n* 18 years or older\n* Diagnosis of ectopic pregnancy\n* Desire for reproduction\n* Ease of return\n* Undetermined pregnancy location with abnormal hCG growth\n* Presence of a heterogeneous adnexal mass on pelvic ultrasound suggestive of a tubal ectopic pregnancy with an hCG level ≤ 3000 mIU\u002Fml\n* Absence of fetal cardiac activity\n* Average diameter of the adnexal mass ≤ 3.5 cm\n* Hemodynamically stable\n* No significant abdominal pain (i.e, \\\u003C 6 on a visual analog scale)\n\nExclusion Criteria:\n\n* Presence of a significant amount of free fluid in the pelvis (as assessed by the ultrasound technician)\n* Allergy to methotrexate or letrozole\n* A reduction in β-hCG ≥ 50% in 2 measurements with 48 hours between them or\n\n  ≥ 85% in 4 days, or ≥ 95% in 7 days before randomization\n* Abnormal liver function test (Alanine transaminase (ALT) ≥ 2 times the upper limit of normal)\n* Abnormal renal function test (glomerular filtration rate ≤ 45 ml\u002Fmin)\n* Hemoglobin \\\u003C10 g\u002Fdl\n* Platelets \\\u003C120.000\u002Fml\n* Presence of heterotopic pregnancy\n* Do not wish to participate in the study.","FEMALE","18 Years",{"count":80,"type":81},130,"ESTIMATED","INTERVENTIONAL",[84],"PHASE4","A randomized clinical trial using oral letrozole 10mg\u002Fday for 7 days, for treating early cases of ectopic pregnancy, compared to intramuscular methotrexate",[87],"Ectopic Pregnancy",[89,9,90],"ectopic pregnancy","methotrexate","2024-04-05",{"date":93,"type":94},"2024-04-09","ACTUAL",{"date":96,"type":94},"2024-03-27",{"date":98,"type":81},"2026-12-31",{"name":5,"class":6},1]