[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619766":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":41,"responsibleParty":60,"collaborators":34,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":34,"enrollmentInfo":72,"targetDuration":34,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":34,"overallStatus":44,"whyStopped":34,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Image guided radiation therapy","ACTIVE_COMPARATOR","This arm will proceed as per the standard of care. The pre-treatment reference plan will be delivered daily for 35 fractions. If a notable change in anatomy is identified, a dose of the day calculation may be performed as per current standard head and neck workflow",[13],"Radiation: Image guided radiation therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Daily Adaptive Radiation Therapy","EXPERIMENTAL","Structures of daily adaptive radiation therapy organ at risk will be AI generated in the Ethos platform on the daily CBCT and then edited by radiation therapy team as required. A rigid registration of CTV targets to the CBCT replicating the current radiation therapy led IGRT process.",[19],"Radiation: Daily adaptive radiation therapy",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"RADIATION","Daily adaptive radiation therapy","Adaptive radiotherapy (ART) is the modification of the radiotherapy plan during treatment to account of changes from the original anatomy and set up. Reduction in treatment volume can be achieved through ART by:\n\n1. adjusting for gradual longitudinal changes in tumour and anatomy\n2. adjusting to account for uncertainty in set up and anatomy via daily online",[15],[27,28],"Daily ART","DART",{"type":22,"name":9,"description":30,"armGroupLabels":31,"otherNames":32},"The pre-treatment reference plan will be delivered daily for 35 fractions.",[9],[33],"IGRT",null,[36],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Andrew McPartlin, MD","CONTACT","416-946-2132","andrew.mcpartlin@uhn.ca",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Princess Margaret Cancer Centre","RECRUITING","Toronto","Ontario","M5G 2M9","Canada","CA",{"type":51,"coordinates":52},"Point",[53,54],-79.39864,43.70643,{"lat":54,"lon":53},[57],{"name":37,"role":38,"phone":58,"phoneExt":59,"email":40},"416-946-4501","4855",{"type":61,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100619766","phase-ii-study-of-daily-adaptive-radiotherapy-for-submandibular-gland-sparing-in-head-and-neck-cancer-100619766",false,"NCT07348887","Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer","Phase II Randomized Trial of RT-Led Daily Adaptive Radiotherapy for Submandibular Gland-Sparing in Head and Neck Cancer (RTL-DART)","RTL-DART","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Histologically proven Squamous Cell carcinoma of head and neck\n* Bilateral neck being treated\n* At least one level 1b not being treated electively and with no target structure, other than elective level II\u002FIII, \\\u003C1cm to spared SMG\n* ECOG PS 0-2\n* Planned for curative (chemo)radiotherapy\n* Able to receive and understand verbal and written information regarding study and able to give written informed consent\n* Be able to lie comfortably on back and to wear immobilization for up to 1 hour\n\nExclusion Criteria:\n\n* As judged by investigator evidence of systemic disease that makes unsuitable for study\n* Pregnancy\n* Underlying salivary dysfunction prior to treatment judged by investigator to affect likelihood of benefit from ART","ALL","18 Years",{"count":73,"type":74},50,"ESTIMATED","INTERVENTIONAL",[77],"NA","This is a randomized, single centre, single blinded prospective study comparing the standard of care imaging guided radiation therapy and daily adaptive radiotherapy (ART) for submandibular gland-sparing in head and neck cancer",[80],"Squamous Cell Cancer of Head and Neck (SCCHN)","2026-03-03",{"date":83,"type":84},"2026-03-04","ACTUAL",{"date":86,"type":84},"2025-10-15",{"date":88,"type":74},"2029-10-01",{"name":5,"class":6},1]