[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100059578":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":32,"responsibleParty":53,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":10,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients 1",null,"Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype\u002Fgenotype correlations.",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients 2","Patients with disease of unknown or incomplete genetic characterization.",{"label":16,"type":10,"description":17,"interventionNames":10},"Subjects","Subjects older than 2 years old with movement disorders and their family members",[19],{"name":20,"affiliation":21,"role":22},"Debra J Ehrlich, M.D.","National Institute of Neurological Disorders and Stroke (NINDS)","PRINCIPAL_INVESTIGATOR",[24,29],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Konjit Yirgashewa","CONTACT","(301) 594-5277","konjit.yirgashewa@nih.gov",{"name":20,"role":26,"phone":30,"phoneExt":10,"email":31},"(301) 443-7888","debra.ehrlich@nih.gov",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"National Institutes of Health Clinical Center","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-77.10026,38.98067,{"lat":45,"lon":44},[48],{"name":49,"role":26,"phone":50,"phoneExt":51,"email":52},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":54,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100059578","phenotypegenotype-correlations-in-movement-disorders-100059578",false,"NCT00018889","Phenotype\u002FGenotype Correlations in Movement Disorders","* INCLUSION CRITERIA:\n* Individuals with suspected movement disorders\n* Family members of movement disorders patients\n* Ability to give informed consent or have a legally authorized representative able to give consent (for adults without consent capacity) or parent\u002Fguardian able to provide informed consent (for a child)\n* If unable to give informed consent, ability to give assent (for children or adults without consent capacity)\n* NIH Employees can participate in this study if they meet eligibility.\n\nEXCLUSION CRITERIA:\n\n* Pregnant women\n* Children less than 2 years of age\n* Employees of the Parkinson's Disease Clinic, NINDS\n\nExclusion criteria for MRI\n\n* Presence of metal in subject s body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if subject was a welder or metal worker, since small metal fragments in the eye may be present.\n* Subject is uncomfortable in small closed spaces (have claustrophobia) so that they would feel uncomfortable in the MRI machine.\n* Unable to lie comfortably on back for up to 1 hour\n* Under 12 years of age\n\nThere is no general exclusion for NIH employees.","ALL","2 Years","100 Years",{"count":65,"type":66},2500,"ESTIMATED","OBSERVATIONAL","The goal of this protocol is to identify families with inherited movement disorders and evaluate disease manifestations to establish an accurate clinical diagnosis by using newest technological advances and investigate the underlying molecular mechanisms. Studies of inherited movement disorders in large families with good genealogical records are especially valuable. Patients with diseases of known molecular basis will be genotyped in order to investigate phenotype\u002Fgenotype correlation. Patients with disease of unknown or incomplete genetic characterization will be studied with a hope of contributing to the identification of specific disease-causing genes and genetic mechanisms responsible for a specific disorder.",[70],"Movement Disorder",[72,73,74,75,76,77,70,78],"Clinical Evaluation","Genetic Study","Essential Tremor","Familial Myoclonus","Hereditary Ataxia","Natural History","Inherited Movement Disorder","2026-06-24",{"date":81,"type":82},"2026-06-25","ACTUAL",{"date":84,"type":82},"2001-10-22",{"name":21,"class":6},1]